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G蛋白偶联受体/G蛋白
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Calcium Channel
CaSR
/ Gadolinium chloride/氯化钆(III)

Gadolinium chloride/氯化钆(III) {[allProObj[0].p_purity_real_show]}

货号：A907506 同义名： 氯化钆 / GdCl3

Stretch-activated calcium channel blocker; calcium-sensing receptor agonist

Gadolinium chloride/氯化钆(III) 化学结构 CAS号：10138-52-0
Gadolinium chloride/氯化钆(III) 化学结构
CAS号：10138-52-0
Gadolinium chloride/氯化钆(III) 3D分子结构
CAS号：10138-52-0
Gadolinium chloride/氯化钆(III) 化学结构 CAS号：10138-52-0
Gadolinium chloride/氯化钆(III) 3D分子结构 CAS号：10138-52-0
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Gadolinium chloride/氯化钆(III) 纯度/质量文件 产品仅供科研

货号：A907506 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

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产品名称 Ca2+ channel-like protein ↓ Calcium Channel ↓ Cav 2.2 ↓ 其他靶点 纯度
CDC25B-IN-2 ✔ Akt 99%+
Clevidipine ✔ 97%
Verapamil HCl ✔ 99%
Amlodipine ✔ 99%
Amlodipine maleate ✔ 98%
(+)-cis-Diltiazem HCl ✔ 99%
Zegocractin ++

Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM

 		99%+
Tanshinone IIA sulfonate sodium ✔ 98%
Ulixacaltamide ++

hCaV3.2, IC50: 110 nM

hCaV3.1, IC50: 50 nM

 		99%+
Dronedarone HCl ✔ 95%
Nitrendipine +

Calcium channel, IC50: 95 nM

 		98%
Efonidipine HCl monoethanolate ✔ 98%
Cinnarizine ✔ 98%
SEA0400 ++

NCX, IC50: 33 nM

 		ROS,ERK,p38 MAPK 99%+
Fasudil HCl ✔ Rho,PKA 98%
ML-9 ✔ MLCK,Akt 99%+
Flunarizine 2HCl +

Calcium channel, Ki: 68 nM

 		95%
Lomerizine 2HCl ✔ 98%
Efonidipine ✔ 98%
Levamlodipine ✔ 98%
Nisoldipine ++

L-type Cav1.2, IC50: 10 nM

 		97%
Isradipine ✔ 98%
Lacidipine ✔ 98%
Lercanidipine ✔ 99%
Loureirin B ✔ Potassium Channel 99%+
Tetracaine HCl ✔ 98%
Manidipine +++

Calcium channel, IC50: 2.6 nM

 		99%
Manidipine Dihydrochlorid +++

Calcium channel, IC50: 2.6 nM

 		98%
Nicardipine ✔ 99%
Wilforgine ✔ 98+%
Econazole ✔ 99%+
Ginsenoside Rd ✔ NF-κB 98%
Fendiline HCl ✔ 98+%
Mesaconitine ✔ 98%
Tetrandrine ✔ 95%
Nifedipine ✔ 95%
Nilvadipine ++++

Calcium channel, IC50: 0.03 nM

 		98%
Barnidipine ++++

[3H]nitrendipine, Ki: 0.21 nM

 		95+%
Azelnidipine ✔ 97%
Levetiracetam ✔ 98%
Nimodipine ✔ 95%
Benidipine HCl ✔ 98%
Pinaverium bromide ✔ 98%
Pranidipine ✔ 99%
NP118809 +

L-type calcium channel, IC50: 12.2 μM

N-type Ca2+ channel, IC50: 0.11 μM

 		98%
Amlodipine Besylate +++

Calcium channel, IC50: 1.9 nM

 		97%
Cilnidipine ✔ 99%
Cinepazide Maleate ✔ 99% (HPLC)
Terfenadine ✔ 98%
YM-58483 ✔ 99%+
Ranolazine ✔ 98%
Praeruptorin A ✔ p38 MAPK,Akt 98%
Ranolazine 2HCl ✔ 98%
Felodipine ++++

L-type calcium channel, IC50: 0.15 nM

 		98%
PD173212 +++

N-type Ca2+ channel, IC50: 36 nM

 		98%
Levamlodipine besylate ✔ 97%
Carboxyamidotriazole Orotate ✔ 98%
IGS-1.76 ✔ 98+%
WH-4-023 ++++

Cav 2.2, IC50: 0.001 μM

 		++++

Cav 2.2, IC50: 0.001 μM

 		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 CaSR ↓ 其他靶点 纯度
NPS-2143 ++++

Ca(2+) receptor, IC50: 43 nM

 		98+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Gadolinium chloride/氯化钆(III) 生物活性

描述 Gadolinium chloride is a specific CaSR agonist.Gadolinium chloride is used in cardiovascular disease research to promote apoptosis in cardiomyocytes, increase ERK1/2 phosphorylation and activate caspase-3. Gadolinium chloride at a concentration of 30 μM for 15 minutes resulted in an increase in Bax expression and caspase-3 activation and a decrease in Bcl-2 expression in H9c2 cells induced by CsA[1].

Gadolinium chloride/氯化钆(III) 参考文献

[1]References are publications that support the biological activity of the product. Nishitani et al (2011) Calcium signaling in live cells on elastic gels under mechanical vibration at subcellular levels. PLoS One. 6 e26181 PMID: 22053183 Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333 Del Favero et al (2012) The stretch-activated channel blocker Gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. Chem.Res.Toxicol. 25 1912 PMID: 22900474 Nagata et al (2008) The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proc.Natl.Acad.Sci.U.S.A. 105 353 PMID: 18162548 If you know of a relevant reference for Gadolinium chloride, please let us know.

Gadolinium chloride/氯化钆(III) 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.79mL

0.76mL

0.38mL

18.97mL

3.79mL

1.90mL

37.93mL

7.59mL

3.79mL

Gadolinium chloride/氯化钆(III) 技术信息

CAS号10138-52-0
分子式Cl3Gd
分子量 263.61
SMILES Code [Gd+3].[Cl-].[Cl-].[Cl-]
MDL No. MFCD00011024
别名 氯化钆 ;GdCl3
运输蓝冰
InChI Key MEANOSLIBWSCIT-UHFFFAOYSA-K
Pubchem ID 61486
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, room temperature

Tags: Gadolinium | 10138-52-0 | GdCl3 | GdCl 3 | GdCl-3 | CaSR Agonist | GPCR/G Protein | CaSR | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Gadolinium chloride/氯化钆(III) 纯度/质量文件 | Gadolinium chloride/氯化钆(III) 亚型比较 | Gadolinium chloride/氯化钆(III) 生物活性 | Gadolinium chloride/氯化钆(III) 参考文献 | Gadolinium chloride/氯化钆(III) 实验方案 | Gadolinium chloride/氯化钆(III) 技术信息

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