GAL-021 a new intravenous Potassium Channel KCa1.1 blocker.
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
GAL-021 is an effective BKCa-channel blocker. It inhibits KCa1.1 in GH3 cells. As a novel breathing control modulator, GAL-021 is selectively modified based on a selective modification of the almitrine pharmacophore. It increases the minute ventilation in rats and non-human primates[1][2]. GAL-021 is in development as a novel modulator for breathing control, aimed at maintaining respiratory drive and safeguarding patients from respiratory complications associated with opioids and other treatments. In GH3 cells, GAL-021 demonstrates a concentration-dependent inhibition of the single-channel activity of KCa1.1 when applied using inside-out patches. Upon testing against a panel of 12 cardiac ion channels, GAL-021 shows an inhibition of 35% or less at a concentration of 30 μM. Kinase inhibition is not significant at 10 μM. In radioligand binding assays at 30 μM, GAL-021 exhibits interactions (defined as more than 50% displacement of radioligand) with adenosine A1 (65% inhibition), A2A (79% inhibition, IC50 approximately 5μM), and A3 (93% inhibition; IC50 approximately 1 μM) receptors, and with 5-HT2B receptors (60% inhibition; IC50 approximately 30 μM)[1].
GAL-021 实验方案
计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.93mL
0.79mL
0.39mL
19.66mL
3.93mL
1.97mL
39.32mL
7.86mL
3.93mL
GAL-021 技术信息
CAS号
1380341-99-0
分子式
C11H22N6O
分子量
254.33
SMILES Code
CCCNC1=NC(N(OC)C)=NC(NCCC)=N1
MDL No.
MFCD31657265
别名
运输
蓝冰
InChI Key
FJNLCHNQVJVCPY-UHFFFAOYSA-N
Pubchem ID
57340959
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formKeep in dark place, inert atmosphere, 2-8°C
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