货号:A246764
同义名:
4-氨基丁酸
/ 4-Aminobutyric acid; Mielomade
4-Aminobutyric acid exhibits inhibitory activity on central nervous system (CNS). It is a natural neurotransmitter.
规格 | 价格 | 会员价 | 库存 | 数量 | |||
---|---|---|---|---|---|---|---|
{[ item.pr_size ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 1周 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
产品名称 | GABA receptor ↓ ↑ | GABAA receptor ↓ ↑ | 其他靶点 | 纯度 | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Niflumic Acid | ✔ | 98% | |||||||||||||||||
Ginkgolide A |
++
GABA receptor, Ki: 14.5 μM |
98% | |||||||||||||||||
Valproic acid sodium | ✔ | HDAC,Autophagy | 97% | ||||||||||||||||
Flumazenil | ✔ | 95% | |||||||||||||||||
Bemegride | ✔ | 98% | |||||||||||||||||
Bicuculline |
+++
GABAA receptor, IC50: 2 μM |
99% | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | 4-Aminobutyric acid (γ-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[3]. Incubation of rat brain 4-aminobutyrate aminotransferase (0.1 mM) with 4-amino-hex-5-enoic acid results in a time-dependent irreversible loss of enzymatic activity.[4]. GME (4-Aminobutyric methyl ester hydrochloride) is hydrolyzed to 4-aminobutyric acid (GABA) by brain homogenates, acts as an inhibitor of GABA binding to crude synaptic plasma membranes, activates the release and inhibits the uptake of GABA by rat synaptosomes and acts as a competitive inhibitor of the so-called GABAse system in vitro[5]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT02330094 | Aneurysmal Subarachnoid Hemorr... 展开 >>hage 收起 << | Phase 4 | Completed | - | United States, Florida ... 展开 >> Mayo Clinic in Florida Jacksonville, Florida, United States, 32224 收起 << |
NCT02349477 | Alcohol Use Disorder ... 展开 >> Alcohol Withdrawal 收起 << | Phase 2 | Active, not recruiting | December 2018 | United States, South Carolina ... 展开 >> Medical University of South Carolina Charleston, South Carolina, United States, 29425 收起 << |
NCT00312260 | Pain | Phase 3 | Unknown | December 2016 | Canada, Ontario ... 展开 >> The Hospital for Sick Children Toronto, Ontario, Canada, M5G 1X8 收起 << |
[3]Kowalczyk P, Kulig K. GABA system as a target for new drugs. Curr Med Chem. 2014;21(28):3294-309.
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
9.70mL 1.94mL 0.97mL |
48.49mL 9.70mL 4.85mL |
96.97mL 19.39mL 9.70mL |
CAS号 | 56-12-2 |
分子式 | C4H9NO2 |
分子量 | 103.12 |
SMILES Code | O=C(O)CCCN |
MDL No. | MFCD00008226 |
别名 | 4-氨基丁酸 ;4-Aminobutyric acid; Mielomade; Mielogen; DF 468; Aminalon; Piperidic acid; Gamma-aminobutyric acid; 4-Aminobutanoic acid; γ-Aminobutyric acid |
运输 | 蓝冰 |
InChI Key | BTCSSZJGUNDROE-UHFFFAOYSA-N |
Pubchem ID | 119 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Keep in dark place, inert atmosphere, room temperature |
溶解方案 |
配制的工作液建议现用现配,短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶。
|