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/ Fluocinolone Acetonide/醋酸氟轻松

Fluocinolone Acetonide/醋酸氟轻松 {[allProObj[0].p_purity_real_show]}

货号：A107277 同义名： 醋酸肤轻松 / Flucort-N; NSC 92339

Fluocinolone acetonide, the acetonide form of fluocinolone, is a derivative of glucocorticoid and is used for the treatment of skin disorders.

Fluocinolone Acetonide/醋酸氟轻松 化学结构 CAS号：67-73-2
Fluocinolone Acetonide/醋酸氟轻松 化学结构
CAS号：67-73-2
Fluocinolone Acetonide/醋酸氟轻松 3D分子结构
CAS号：67-73-2
Fluocinolone Acetonide/醋酸氟轻松 化学结构 CAS号：67-73-2
Fluocinolone Acetonide/醋酸氟轻松 3D分子结构 CAS号：67-73-2
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Fluocinolone Acetonide/醋酸氟轻松 纯度/质量文件 产品仅供科研

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Fluocinolone Acetonide/醋酸氟轻松 生物活性

描述 Fluocinolone, a potent glucocorticoid receptor agonist, effectively prevents lipid accumulation and inflammation. It also promotes the proliferation of dental pulp cells (DPCs), suggesting a potential role in the repair of injured pulp tissues. Fluocinolone is being researched for its effectiveness in preventing chemotherapy-induced peripheral neuropathy, particularly associated with the use of Paclitaxel[1].[2].[3].[4].

Fluocinolone Acetonide/醋酸氟轻松 动物研究

Animal study Fluocinolone (500 μg/kg, intraperitoneal injection, once daily for 2 weeks) inhibits the onset of significant peripheral neuropathy in a PTX-induced mouse model[3].

Fluocinolone Acetonide/醋酸氟轻松 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03345914 Dermatitis, Atopic Phase 3 Recruiting April 12, 2019 United States, Alabama ... 展开 >> Regeneron Investigational Site Recruiting Birmingham, Alabama, United States, 35209 United States, California Regneron Investigational Site Recruiting Bakersfield, California, United States, 93309 Regeneron Investigational Site Recruiting Long Beach, California, United States, 90808 Regeneron Investigational Site Recruiting Mission Viejo, California, United States, 92691 United States, Florida Regeneron Investigational Site Recruiting Coral Gables, Florida, United States, 33146 United States, Georgia Regeneron Investigational Site Recruiting Macon, Georgia, United States, 31217 Regeneron Investigational Site Recruiting Sandy Springs, Georgia, United States, 30328 United States, Maryland Regeneron Investigational Site Recruiting Rockville, Maryland, United States, 20850 United States, New York Regeneron Investigational Site Recruiting Forest Hills, New York, United States, 11375 Regeneron Investigational Site Recruiting New York, New York, United States, 10029 United States, Texas Regeneron Investigational Site Recruiting Bellaire, Texas, United States, 77401 Regeneron Investigational Site Recruiting San Antonio, Texas, United States, 78218 United States, Virginia Regeneron Investigational Site Recruiting Norfolk, Virginia, United States, 23502 Poland Regeneron Investigational Site Recruiting Białystok, Poland, 15-453 Regeneron Investigational Site Recruiting Katowice, Poland, 40-611 Regeneron Investigational Site Recruiting Katowice, Poland, 40-648 Regeneron Investigational Site Recruiting Warsaw, Poland, 01-142 Regeneron Investigational Site Recruiting Warsaw, Poland, 02-758 Regeneron Investigational Site Recruiting Warszawa, Poland, 01-817 Regeneron Investigational Site Recruiting Wrocław, Poland, 50-381 Regeneron Investigational Site Recruiting Świętokrzyskie, Poland, 27-400 收起 <<
NCT02260986 Atopic Dermatitis Phase 3 Completed - -
NCT01946386 Psoriasis Vulgaris Phase 1 Completed - France ... 展开 >> CPCAD, Centre de Pharmacologie Clinique Appliquée à la Dermatologie Nice, France, 06202 收起 <<

Fluocinolone Acetonide/醋酸氟轻松 参考文献

[1]Nguyen L T H, et al. The potential of fluocinolone acetonide to mitigate inflammation and lipid accumulation in 2D and 3D foam cell cultures [J]. BioMed Research International, 2018, 2018.

[2]Liu Z, et al. Fluocinolone acetonide promotes the proliferation and mineralization of dental pulp cells [J]. Journal of endodontics, 2013, 39(2): 217-222.

[3]Cetinkaya-Fisgin A, et al. Identification of fluocinolone acetonide to prevent paclitaxel‐induced peripheral neuropathy [J]. Journal of the Peripheral Nervous System, 2016, 21(3): 128-133.

[4]Nehmé A, et al. Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells [J]. BMC medical genomics, 2009, 2(1): 1-14.

Fluocinolone Acetonide/醋酸氟轻松 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.21mL

0.44mL

0.22mL

11.05mL

2.21mL

1.10mL

22.10mL

4.42mL

2.21mL

Fluocinolone Acetonide/醋酸氟轻松 技术信息

CAS号67-73-2
分子式C24H30F2O6
分子量 452.49
SMILES Code O=C([C@]([C@@]1([H])C[C@@]2([H])[C@@](C[C@H](F)C3=CC4=O)([H])[C@@](F)([C@]3(C=C4)C)[C@@H](O)C5)(OC(C)(C)O1)[C@]25C)CO
MDL No. MFCD00010525
别名 醋酸肤轻松 ;Flucort-N; NSC 92339; Fluocinolone(Acetonide)
运输蓝冰
InChI Key FEBLZLNTKCEFIT-VSXGLTOVSA-N
Pubchem ID 6215
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, 2-8°C
溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方

IP 2% DMSO+2% Tween80+30% PEG300+water 8 mg/mL clear

PO 0.5% CMC-Na 30 mg/mL suspension

Tags: Fluocinolone Acetonide | Fluocinolone acetonide;Flucort-N;Fluocinolone Acetonide, Synandone, Flucinar, Fluonid, Jellin, Sinalar;NSC 92339 | 醋酸肤轻松 | Progesterone | Glucocorticoid | Glucocorticoid Receptor | AmBeed-信号通路专用抑制剂 | Fluocinolone Acetonide/醋酸氟轻松 纯度/质量文件 | Fluocinolone Acetonide/醋酸氟轻松 生物活性 | Fluocinolone Acetonide/醋酸氟轻松 临床数据 | Fluocinolone Acetonide/醋酸氟轻松 参考文献 | Fluocinolone Acetonide/醋酸氟轻松 实验方案 | Fluocinolone Acetonide/醋酸氟轻松 技术信息

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