There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Fipronil is a broad-spectrum insecticide effective against a variety of pests including Lepidoptera species, thrips, locusts, ants, cockroaches, fleas, and ticks. It selectively inhibits GABA receptors, demonstrating an IC50 of 30 nM for cockroach GABA receptors compared to 1600 nM for rat GABA receptors. Additionally, fipronil is sensitive to glutamate-gated chloride channels (GluCls) which are present in insects like cockroaches but absent in mammals. It has also been found to induce apoptosis in HepG2 cells and to upregulate the expression of CYP1A1 and CYP3A4 mRNA in human hepatocytes[1].[2].
Fipronil/氟虫腈 动物研究
Animal study
Fipronil also affects two types of glutamate-induced chloride currents, desensitizing and non-desensitizing, with IC50 values of 800 nM and 10 nM, respectively[2].Fipronil's selectivity is highlighted by its greater effectiveness on cockroach GABA receptors compared to rat GABA receptors[2].Moreover, fipronil blocks cockroach GABA receptors in both their resting and activated states, with IC50s of 28 nM and 35 nM, respectively[2].
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