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/ 组胺受体 / Fexofenadine

Fexofenadine {[allProObj[0].p_purity_real_show]}

货号：A191730

Fexofenadine is an antihistamine pharmaceutical drug used in the treatment of allergy symptoms, such as hay fever, nasal congestion, and urticaria.

Fexofenadine 化学结构 CAS号：83799-24-0
Fexofenadine 化学结构
CAS号：83799-24-0
Fexofenadine 3D分子结构
CAS号：83799-24-0
Fexofenadine 化学结构 CAS号：83799-24-0
Fexofenadine 3D分子结构 CAS号：83799-24-0
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Fexofenadine 纯度/质量文件 产品仅供科研

货号：A191730 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

更多 >
产品名称 H1 receptor ↓ H2 receptor ↓ H3 receptor ↓ H4 receptor ↓ Histamine receptor ↓ 其他靶点 纯度
Hydroxyzine 2HCl 99+%
Cyclizine ✔ 97%
Loratadine +

B(0)AT2, IC50: 4 μM

 		98%
Desloratadine ++

Histamine H1 receptor, IC50: 51 nM

 		98%
Doxylamine succinate ✔ 99%
Ebastine ✔ 98%
Tripelennamine HCl +

H1 receptor, IC50: 30 μM

 		98%
Meclizine 2HCl ✔ 98%
Chlorpheniramine maleate +++

Histamine H1 receptor, IC50: 12 nM

 		99%
Diphenhydramine HCl ✔ 99%
Alcaftadine ++++

H1 receptor, pKi: 8.5

 		++

H2 receptor, pKi: 7.2

 		99%+
Fexofenadine HCl ++

Histamine H1 receptor, IC50: 246 nM

 		99%+
Bilastine +++

H1 receptor, Ki: 44.15 nM

 		98%
Pemirolast potassium ✔ 98%
Bepotastine besilate +

Histamine H1 receptor, pIC50: 5.7

 		98%
Mizolastine +++

Histamine H1 receptor, IC50: 47 nM

 		98%
Brompheniramine maleate ✔ 98%
Carbinoxamine maleate salt ✔ 99+%
Clemastine fumarate ++++

Histamine H1 receptor, IC50: 3 nM

 		98%
Ketotifen fumarate salt ✔ 95%
Rupatadine Fumarate ++

Histamine H1 receptor, Ki: 102 nM

 		PAFR 98%
Famotidine ✔ 97%
Roxatidine Acetate HCl +

Histamine H2 receptor, IC50: 3.2 μM

 		98%
Lafutidine ✔ 99%
Cimetidine ✔ 98%
Nizatidine ++++

Histamine H2 receptor, IC50: 0.9 nM

 		AChE 98%
Ranitidine ✔ 96%
Betahistine +

Histamine H3 receptor, IC50: 1.9 μM

 		99%
Ciproxifan maleate +++

Histamine H3 receptor, IC50: 9.2 nM

 		99%+
S 38093 ++

human H3 receptor, Ki: 1.2 μM

rat H3 receptor, Ki: 1.44 μM

 		98%
JNJ-7777120 ++++

Histamine H4 receptor, Ki: 4.5 nM

 		99%
Azelastine HCl ✔ 98%
Epinastine HCl ✔ 99%
Levodropropizine ✔ 97%
Cyproheptadine HCl ✔ 98%
Hesperetin ✔ 97%
Olopatadine HCl ✔ 98%
Mianserin HCl ✔ 99+%
Buclizine 2HCl ✔ 95%
Latrepirdine 2HCl ✔ GluR 99%
Cetirizine 2HCl ✔ 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Fexofenadine 生物活性

描述 Fexofenadine, also known by its development code MDL-16455, is an orally active, non-sedative antagonist of the H1 receptor. It is commonly utilized in the study of allergic rhinitis and chronic idiopathic urticaria[1].[2].[3].

Fexofenadine 动物研究

Animal study When administered orally at doses of 5 to 20 mg/kg daily for three weeks, Fexofenadine hydrochloride effectively reduces eosinophilia and systemic anaphylaxis in C57BL/6 mice infected with T. spiralis[1].

Fexofenadine 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01761890 - Recruiting November 2020 Italy ... 展开 >> Centro Oncologico Basilicata Not yet recruiting Rionero in Vulture, Potenza, Italy Contact: Pellegrino Musto, MD, PhD          Principal Investigator: Pellegrino MUSTO, Pr.          Sub-Investigator: Giuseppe Pietrantuono, Dr.          S.O.C. di Ematologia - Azienda Ospedaliera - SS. Antonio e Biagio e Cesare Arrigo Recruiting Alessandria, Italy Contact: Massimo Pini          Sub-Investigator: Gioacchino Catania          Principal Investigator: Massimo Pini          Azienda Ospedaliera - Nuovo Ospedale "Torrette" Recruiting Ancona, Italy Contact: Serena Rupoli          Principal Investigator: Serena Rupoli          Sub-Investigator: Anna Rita          U.O.C. Ematologia e Terapia Cellulare - Ospedale "C. e G. Mazzoni" di Ascoli Piceno Not yet recruiting Ascoli Piceno, Italy Contact: Catia Bigazzi          Principal Investigator: Catia Bigazzi          Az.Ospedaliera S.G.Moscati Not yet recruiting Avellino, Italy Contact: Fausto Palmieri          Principal Investigator: Fausto Palmieri          Sub-Investigator: Antonio Volpe          UO Ematologia con trapianto-Università degli Studi di Bari Aldo Moro Not yet recruiting Bari, Italy Contact: Giorina Specchia          Principal Investigator: Giorgina Specchia          Sub-Investigator: Antonella Russo          Azienda Ospedaliera Di Bologna Policlinico S. Orsola - Malpighi Recruiting Bologna, Italy, 40138 Contact: Gianantonio Rosti, Dr.       gianantonio.rosti@unibo.it    Principal Investigator: Gianantonio Rosti, Dr.          U.O.C. di Onco-Ematologia - Centro di Ricerca e Formazione ad Alta tecnologia nelle Scienze Biomediche Not yet recruiting Campobasso, Italy Contact: Sergio Storti          Principal Investigator: Sergio Storti          Sub-Investigator: Cristiana Gasbarrino, Dr.          US Dipartimentale - Centro per le malattie del sangue - Ospedale Civile - S.Giacomo Not yet recruiting Castelfranco Veneto, Italy Contact: Giuseppe Tagariello, Dr.          Principal Investigator: Giuseppe Tagariello, Dr.          Sub-Investigator: Roberto Sartori, Dr.          Università di Catania - Cattedra di Ematologia - Ospedale "Ferrarotto" Recruiting Catania, Italy Contact: Fabio Stagno          Principal Investigator: Fabio Stagno          Azienda Ospedaliero Universitaria Arcispedale Sant'Anna Dipartimento di Scienze Mediche Sezione di Ematologia e Fisiopatologia dell'Emostasi Not yet recruiting Ferrara, Italy Contact: Antonio Cuneo          Principal Investigator: Antonio Cuneo          Sub-Investigator: Francesco Cavazzini          Azienda Ospedaliera di Firenze Not yet recruiting Firenze, Italy, 50011 Contact: Alberto BOSI, Pr.          Principal Investigator: Alberto BOSI, Pr.          Sub-Investigator: Antonella Gozzini, Dr.          Centro Aziendale di Ematologia ASL N. 6 Not yet recruiting Livorno, Italy Contact: Enrico CAPOCHIANI    0586223111    e.capochiani@nord.usl6.toscana.it    Principal Investigator: Enrico Capochiani, MD          Azienda Ospedaliera Universitaria - Policlinico G. Martino Dipartimento di Medicina Interna - U.O. Messina Not yet recruiting Messina, Italy Contact: Caterina Musolino          Principal Investigator: Caterina Musolino          Sub-Investigator: Alessandro Allegra          Divisione di Ematologia - Azienda Ospedaliera Ospedali Riuniti "Papardo Piemonte" Not yet recruiting Messina, Italy Contact: Maura Brugiatelli          Principal Investigator: Maura Brugiatelli          Sub-Investigator: Laura Nocilli          Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico UOC Oncoematologia- Padiglione Marcora 2° piano Recruiting Milano, Italy Contact: Alessandra Iurlo          Principal Investigator: Alessandra Iurlo          Ospedale San Gennaro - ASL Napoli 1 Not yet recruiting Napoli, Italy Contact: Lucia Mastrullo          Principal Investigator: Lucia Mastrullo          Sub-Investigator: Maria Rosaria          zienda Ospedaliera Universitaria - Università degli Studi di Napoli "Federico II" - Facoltà di Medicina e Chirurgia Not yet recruiting Napoli, Italy Contact: Fabrizio Pane          Principal Investigator: Fabrizio Pane          Sub-Investigator: Luigia Luciano          Dip. di Scienze Cliniche e Biologiche - Ospedale S. Luigi Gonzaga-Medicina Interna 2 Not yet recruiting Orbassano, Italy Contact: Giovanna Rege          Principal Investigator: Giovanna Rege          Sub-Investigator: Carmen Fava          La Maddalena Casa di Cura di Alta Specialità Dipartimento Oncologico di III Livello Not yet recruiting Palermo, Italy Contact: Maurizio Musso          Principal Investigator: Maurizio Musso          Sub-Investigator: Ferdinando Porretto          zienda Ospedaliera Universitaria - Università degli Studi di Napoli "Federico II" - Facoltà di Medicina e Chirurgia Not yet recruiting Palermo, Italy Contact: Diamante Turri          Principal Investigator: Diamante Turri          Cattedra di Ematologia CTMO Università degli Studi di Parma Not yet recruiting Parma, Italy Contact: Monica Crugnola          Principal Investigator: Monica Crugnola          Sub-Investigator: Franco Aversa          U.O. Ematologia Clinica - Azienda USL di Pescara Not yet recruiting Pescara, Italy Contact: Roberto Di Lorenzo          Principal Investigator: Roberto Di Lorenzo          Sub-Investigator: Giuseppina Ricciuti          Unità Operativa Ematologia e Centro Trapianti - Dipartimento di Oncologia ed Ematologia - AUSL Ospedale di Piacenza Not yet recruiting Piacenza, Italy Contact: Daniele Vallisa, Dr.          Principal Investigator: Daniele Vallisa, Dr.          Sub-Investigator: Elena Trabacchi, Dr.          Dipartimento Emato-Oncologia A.O."Bianchi-Melacrino-Morelli" Not yet recruiting Reggio Calabria, Italy Contact: Francesco Nobile          Principal Investigator: Francesco Nobile          Sub-Investigator: Bruno Martino          Unità Operativa Complessa di Ematologia - Arcispedale S. Maria Nuova Not yet recruiting Reggio Emilia, Italy Contact: Paolo Avanzini          Principal Investigator: Paolo Avanzini          Sub-Investigator: Isabella Capodanno          Az. Ospedaliera "Sant' Andrea"-Università la Sapienza Seconda Facoltà di Medicina e Chirurgia Not yet recruiting Roma, Italy Contact: Enrico Montefusco          Principal Investigator: Enrico Montefusco          Sub-Investigator: Raffaele Porrini          Complesso Ospedaliero S. Giovanni Addolorata Not yet recruiting Roma, Italy Contact: Michele Cedrone, Dr.          Sub-Investigator: Barbara Anaclerico, Dr.          Principal Investigator: Michele Cedrone, Dr.          Padiglione Cesalpino - I piano - Divisione di Ematologia - Ospedale S. Camillo Not yet recruiting Roma, Italy Contact: Leonardo Pacilli          Principal Investigator: Leonardo Pacilli          S.C. di Ematologia e Trapianti - I.F.O. Istituto Nazionale Tumori Regina Elena Not yet recruiting Roma, Italy Contact: Atelda Romano, Dr.          Principal Investigator: Atelda Romano, Dr.          Sub-Investigator: Laura Nocilli, Dr.          U.O.C. Ematologia - Ospedale S.Eugenio Not yet recruiting Roma, Italy Contact: Elisabetta Abruzzese          Principal Investigator: Elisabetta Abruzzese          Sub-Investigator: Monika Trawinska          Università Cattolica del Sacro Cuore - Policlinico A. Gemelli Not yet recruiting Roma, Italy Contact: Simona Sica          Principal Investigator: Simona Sica          Sub-Investigator: Federica Sorà          Rotondo Istituto di Ematologia - IRCCS Ospedale Casa Sollievo della Sofferenza Not yet recruiting San Giovanni Rotondo, Italy Contact: Nicola Cascavilla          Principal Investigator: Nicola Cascavilla          Sub-Investigator: Antonietta Pia          U.O.C. Ematologia e Trapianti - A.O. Senese - Policlinico " Le Scotte" Not yet recruiting Siena, Italy Contact: Monica Bocchia          Principal Investigator: Monica Bocchia          Sub-Investigator: Lara Aprile          Dipartimento di Oncologia ed Ematologia S.C. Ematologia 2 A.O. Città della Salute e della Scienza di Torino San Giovanni Battista Not yet recruiting Torino, Italy Contact: Patrizia Pregno          Principal Investigator: Patrizia Pregno          Sub-Investigator: Paola Riccomagno          Clinica Ematologica - Policlinico Universitario Not yet recruiting Udine, Italy Contact: Mario Tiribelli          Principal Investigator: Mario Tiribelli          Sub-Investigator: Luciana Marin          Università degli Studi di Verona - A. O. - Istituti Ospitalieri di Verona- Div. di Ematologia - Policlinico G.B. Rossi Not yet recruiting Verona, Italy Contact: Giovanni Pizzolo          Principal Investigator: Giovanni Pizzolo          Sub-Investigator: Massimiliano Bonifacio 收起 <<
NCT02796898 Prostate Cancer ... 展开 >> Rising Prostate Specific Antigen (PSA) 收起 << Phase 1 Phase 2 Recruiting December 31, 2019 United States, New Jersey ... 展开 >> AdvanceMed Research Completed Lawrence, New Jersey, United States, 08648 United States, New York Montefiore Medical Center- Montefiore Medical Park Not yet recruiting Bronx, New York, United States, 10461 Contact: Gartrell Benjamin, MD    718-405-8404    bgartrel@montefiore.org    Eastchester Center for Cancer Care Recruiting Bronx, New York, United States, 10469 Contact: Carmen Vicuna    718-732-4078    cvicuna@nycancer.com    AccuMed Research Associates Recruiting Garden City, New York, United States, 11530-1664 Contact: Tammi Allegra, RN    516-746-2190    tallegra.accumedresearch@gmail.com    United States, Pennsylvania MidLantic Urology Recruiting Bala-Cynwyd, Pennsylvania, United States, 19004 Contact: Cheryl A Zinar, RN, BSN    610-667-0458       Principal Investigator: Laurence H Belkoff, DO 收起 <<
NCT01850628 - Recruiting February 2020 United States, Florida ... 展开 >> University of Florida Recruiting Gainesville, Florida, United States, 32610 Principal Investigator: Carmen Allegra, MD          United States, Missouri Washington University School of Medicine Recruiting St Louis, Missouri, United States, 63110 Principal Investigator: Adel Tabchy, MD          United States, New York New York University School of Medicine Recruiting New York, New York, United States, 10016 United States, Pennsylvania Allegheny General Hospital Recruiting Pittsburgh, Pennsylvania, United States, 15212 Principal Investigator: Thomas Julian, MD          United States, Texas Baylor College of Medicine Recruiting Houston, Texas, United States, 77030 Principal Investigator: Mothaffar Rimawi, MD 收起 <<

Fexofenadine 参考文献

[1]Watanabe N, et al. The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis. Int Immunopharmacol. 2004 Mar;4(3):367-75.

[2]Park IH, et al. Histamine Promotes the Release of Interleukin-6 via the H1R/p38 and NF-κB Pathways in Nasal Fibroblasts. Allergy Asthma Immunol Res. 2014 Nov;6(6):567-72.

[3]Ming X, et al. Vectorial transport of fexofenadine across Caco-2 cells: involvement of apical uptake and basolateral efflux transporters. Mol Pharm. 2011 Oct 3;8(5):1677-86.

Fexofenadine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.99mL

0.40mL

0.20mL

9.97mL

1.99mL

1.00mL

19.93mL

3.99mL

1.99mL

Fexofenadine 技术信息

CAS号83799-24-0
分子式C32H39NO4
分子量 501.66
SMILES Code CC(C(O)=O)(C1=CC=C(C(CCCN2CCC(C(C3=CC=CC=C3)(C4=CC=CC=C4)O)CC2)O)C=C1)C
MDL No. MFCD00871892
别名
运输蓝冰
InChI Key RWTNPBWLLIMQHL-UHFFFAOYSA-N
Pubchem ID 3348
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, store in freezer, under -20°C

Tags: Fexofenadine | Histamine Receptor | AmBeed-信号通路专用抑制剂 | Fexofenadine 纯度/质量文件 | Fexofenadine 亚型比较 | Fexofenadine 生物活性 | Fexofenadine 临床数据 | Fexofenadine 参考文献 | Fexofenadine 实验方案 | Fexofenadine 技术信息

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