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/ Fenoldopam mesylate/非诺多泮甲磺酸盐

Fenoldopam mesylate/非诺多泮甲磺酸盐 {[allProObj[0].p_purity_real_show]}

货号：A316918 同义名： Fenoldopam methanesulfonate; SKF-82526 mesylate

Fenoldopam mesylate is a partial specific agonist of D1 receptor, a synthetic benzoxipine derivative.

Fenoldopam mesylate/非诺多泮甲磺酸盐 化学结构 CAS号：67227-57-0
Fenoldopam mesylate/非诺多泮甲磺酸盐 化学结构
CAS号：67227-57-0
Fenoldopam mesylate/非诺多泮甲磺酸盐 3D分子结构
CAS号：67227-57-0
Fenoldopam mesylate/非诺多泮甲磺酸盐 化学结构 CAS号：67227-57-0
Fenoldopam mesylate/非诺多泮甲磺酸盐 3D分子结构 CAS号：67227-57-0
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Fenoldopam mesylate/非诺多泮甲磺酸盐 纯度/质量文件 产品仅供科研

货号：A316918 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

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产品名称 D1 receptor ↓ D2 receptor ↓ D3 receptor ↓ D4 receptor ↓ D5 receptor ↓ DAT ↓ Dopamine receptor ↓ 其他靶点 纯度
Penfluridol +

Dopamine receptor, Ki: 1.6 μM

 		98%
Ansofaxine HCl ++

Dopamine receptor, IC50: 491 nM

 		99%
Tetrahydroberberine +

D2 receptor, pKi: 6.08

 		98+%
Prochlorperazine Maleate ✔ 98% (HPLC)
Olanzapine ✔ 99+%
Trifluoperazine ++++

Dopamine D2 receptor, IC50: 1.1 nM

 		98%
Ropinirole HCl ++

D2 receptor, Ki: 29 nM

 		99%
Lurasidone ++++

D2 receptor, Ki: 1 nM

 		98%
Levosulpiride ✔ 99+%
Pridopidine ✔ 95%
Metoclopramide ✔ ✔ 99+%
Molindone HCl ✔ 99%
Sulpiride ✔ 99+%
Perospirone ++++

D2 receptor, Ki: 1.4 nM

 		99%
Perospirone HCl ++++

D2 receptor, Ki: 1.4 nM

 		99%
Phenothiazine ✔ 98%
Pimozide +

Dopamine D1 receptor, Ki: 6600 nM

 		+++

Dopamine D2 receptor, Ki: 3.0 nM

 		++++

Dopamine D3 receptor, Ki: 0.83 nM

 		98%
Rotundine ++

D1 receptor, IC50: 166 nM

 		+

D2 receptor, IC50: 1.47 μM

 		+

D3 receptor, IC50: 3.25 μM

 		98%
Domperidone ✔ 99+%
ONC206 ✔ 99%
Pimethixene maleate ++

Dopamine D1 Receptor, pKi: 6.37

 		+++

Dopamine D2 Receptor, pKi: 8.19

 		++

Dopamine D4.4 Receptor, pKi: 7.54

 		97%
Loxapine succinate ++

D1 receptor (human), Ki: 26 nM

D2 receptor (Human), Ki: 62 nM

 		++

D2 receptor (human), Ki: 24 nM

D2 receptor (bovine), Ki: 26 nM

 		+++

D4 receptor (human), Ki: 7.5 nM

 		98%
Chlorprothixene +++

D1 receptor, Ki: 18 nM

 		+++

D2 receptor, Ki: 2.96 nM

 		+++

D3 receptor, Ki: 4.56 nM

 		+++

D5 receptor, Ki: 9 nM

 		99%
SCH-23390 HCl ++++

D1 dopamine receptor, Ki: 0.2 nM

 		++++

D5 dopamine receptor, Ki: 0.3 nM

 		98%
MPP+ iodide ✔ 97%
σ1 Receptor antagonist-1 +

DAT, pKi: 5.8

 		97%
Benztropine mesylate ++

DAT, IC50: 118 nM

 		98%
Azaperone ✔ 98%
Ziprasidone HCl ✔ 98+%
Paliperidone ✔ 98%
Alizapride HCl ✔ 99+%
Amisulpride ✔ 98%
Quetiapine hemifumarate ✔ Adrenergic Receptor 98%
Clozapine N-oxide ✔ 99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Fenoldopam mesylate/非诺多泮甲磺酸盐 生物活性

描述 Fenoldopam mesylate is a selective agonist of DA-1 receptors. It is currently used for the in-hospital treatment of severe hypertension. Fenoldopam mesylate was found to be effective in reducing the onset of postoperative AKI (Acute Kidney Injury), when used before the development of the kidney damage[3]. At higher doses, fenoldopam lowers blood pressure but still maintains renal perfusion. In addition to its renal vasodilator activity, fenoldopam is natriuretic, possibly resulting from a direct effect of DA1 receptors on the proximal convoluted tubule. In animals with spontaneous or drug-induced renal failure, fenoldopam improves renal function[4]. In hemodynamically stable cardiac surgery patients with preserved renal function, an infusion of 0.1 mg/kg/min of fenoldopam mesylate has no influence on systemic hemodynamics while increasing renal blood flow[5]. Fenoldopam CRI at 0.1 µg/kg/min did not have a clinically relevant effect on kidney function parameters in dogs with severe heatstroke-associated AKI[6]. The selective dopamine-1 agonist fenoldopam mesylate does not prevent further renal function deterioration after contrast administration in patients with chronic renal insufficiency[7].

Fenoldopam mesylate/非诺多泮甲磺酸盐 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00557219 Acute Renal Failure Phase 3 Terminated(Main cooperator fin... 展开 >>ished cooperation) 收起 << - Poland ... 展开 >> Department of Cardiac Anesthesiology, Medical University of Gdańsk Gdańsk, Poland, 80-211 收起 <<
NCT00122018 Kidney Failure, Acute ... 展开 >> Kidney Failure, Chronic Cardiac Surgical Procedures 收起 << Phase 2 Completed - -
NCT01690832 Coronary Artery Disease Phase 4 Unknown December 2014 Italy ... 展开 >> Sapienza University Rome, Lazio, Italy, 00166 收起 <<

Fenoldopam mesylate/非诺多泮甲磺酸盐 参考文献

[1]Hammer GB, Verghese ST, et al. Pharmacokinetics And Pharmacodynamics Of Fenoldopam Mesylate For Blood Pressure Control In Pediatric Patients. BMC Anesthesiol. 2008 Oct 6;8:6.

[2]Vernejoul F, Damase-Michel C, et al. In vivo effects of fenoldopam on autonomic nervous system after inhibition or activation of ganglionic transmission. Eur J Pharmacol. 2002 May 31;444(3):197-202.

[3]Noce A, Marrone G, Rovella V, et al. Fenoldopam Mesylate: A Narrative Review of Its Use in Acute Kidney Injury. Curr Pharm Biotechnol. 2019;20(5):366‐375

[4]Nichols AJ, Ruffolo RR Jr, Brooks DP. The pharmacology of fenoldopam. Am J Hypertens. 1990;3(6 Pt 2):116S‐119S

[5]Meco M, Cirri S. Effects of fenoldopam mesylate on central hemodynamics and renal flow in patients undergoing cardiac surgery: color Doppler echocardiographic evaluation. J Cardiothorac Vasc Anesth. 2010;24(1):58‐62

[6]Segev G, Bruchim Y, Berl N, Cohen A, Aroch I. Effects of fenoldopam on kidney function parameters and its therapeutic efficacy in the management of acute kidney injury in dogs with heatstroke. J Vet Intern Med. 2018;32(3):1109‐1115

[7]Stone GW, McCullough PA, Tumlin JA, et al. Fenoldopam mesylate for the prevention of contrast-induced nephropathy: a randomized controlled trial. JAMA. 2003;290(17):2284‐2291

Fenoldopam mesylate/非诺多泮甲磺酸盐 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.49mL

0.50mL

0.25mL

12.44mL

2.49mL

1.24mL

24.88mL

4.98mL

2.49mL

Fenoldopam mesylate/非诺多泮甲磺酸盐 技术信息

CAS号67227-57-0
分子式C17H20ClNO6S
分子量 401.86
SMILES Code OC1=C(O)C(Cl)=C2C(C(C3=CC=C(O)C=C3)CNCC2)=C1.CS(=O)(O)=O
MDL No. MFCD04112986
别名 Fenoldopam methanesulfonate; SKF-82526 mesylate; Fenoldopam mesylate, Corlopam, SKF 82526J; SKF 82526J; Fenoldopam (mesylate); Corlopam mesylate; SKF 82526 (mesylate)
运输蓝冰
InChI Key CVKUMNRCIJMVAR-UHFFFAOYSA-N
Pubchem ID 49659
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, room temperature

Tags: Fenoldopam mesylate/非诺多泮甲磺酸盐 |Fenoldopam mesylate/非诺多泮甲磺酸盐 | Fenoldopam methanesulfonate | SKF-82526 mesylate | Fenoldopam mesylate, Corlopam, SKF 82526J | SKF 82526J | Fenoldopam (mesylate) | Corlopam mesylate | SKF 82526 (mesylate) | 67227-57-0 | 细胞凋亡诱导剂 | 胸苷合成酶 | 多巴胺受体 | 凋亡 | Fenoldopam mesylate/非诺多泮甲磺酸盐 纯度/质量文件 | Fenoldopam mesylate/非诺多泮甲磺酸盐 亚型比较 | Fenoldopam mesylate/非诺多泮甲磺酸盐 生物活性 | Fenoldopam mesylate/非诺多泮甲磺酸盐 临床数据 | Fenoldopam mesylate/非诺多泮甲磺酸盐 参考文献 | Fenoldopam mesylate/非诺多泮甲磺酸盐 实验方案 | Fenoldopam mesylate/非诺多泮甲磺酸盐 技术信息

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