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/ Empirical Formula/犬尿喹啉酸

Empirical Formula/犬尿喹啉酸 {[allProObj[0].p_purity_real_show]}

货号：A141971 同义名： 犬尿喹啉酸 / Quinurenic acid; Kynurenic acid

Kynurenic Acid is a broad spectrum glutamatergic antagonist which can antagonize NMDA, kainate and AMPA receptors.

Empirical Formula/犬尿喹啉酸 化学结构 CAS号：492-27-3
Empirical Formula/犬尿喹啉酸 化学结构
CAS号：492-27-3
Empirical Formula/犬尿喹啉酸 3D分子结构
CAS号：492-27-3
Empirical Formula/犬尿喹啉酸 化学结构 CAS号：492-27-3
Empirical Formula/犬尿喹啉酸 3D分子结构 CAS号：492-27-3
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Empirical Formula/犬尿喹啉酸 纯度/质量文件 产品仅供科研

货号：A141971 标准纯度： {[allProObj[0].p_purity_real_show]}
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Empirical Formula/犬尿喹啉酸 生物活性

靶点

  • NMDA receptor

  • NMDA receptor
描述 Kynurenic acid (KYNA) is an endogenous antagonist of glutamate in the central nervous system. It is most active as an antagonist at receptors sensitive to N‐methyl‐D‐aspartate (NMDA) which regulate neuronal excitability and plasticity, brain development and behaviour[3]. Peripheral administration of kynurenic acid, at a dose that caused plasma levels to increase 430-fold, resulted in only 4-fold increases in striatal ECF(extracellular fluid) concentrations[4]. KYNA has a significant protective effect on liver injury induced by thioacetamide (TAA)[5].

Empirical Formula/犬尿喹啉酸 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03557684 Depression Early Phase 1 Recruiting July 31, 2020 United States, California ... 展开 >> UCLA Cousins Center for Psychoneuroimmunology Recruiting Los Angeles, California, United States, 90095 Contact: Gracie Pineda    310-825-8425    grpineda@g.ucla.edu    Principal Investigator: Joshua H Cho, MD, PhD 收起 <<
NCT00573300 - Completed - United States, Massachusetts ... 展开 >> Freedom Trail Clinic Boston, Massachusetts, United States, 02114 收起 <<
NCT02234752 Schizophrenia ... 展开 >> Schizoaffective Disorder 收起 << Phase 2 Terminated(Funding no longer a... 展开 >>vailable and PI no longer working at the institution) 收起 << - United States, Maryland ... 展开 >> Sheppard Pratt Health System Baltimore, Maryland, United States, 21204 收起 <<

Empirical Formula/犬尿喹啉酸 参考文献

[1]Sekine A, Okamoto M, et al. Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro. Springerplus. 2015 Feb 1;4:48.

[2]Di Serio C, Cozzi A, et al. Kynurenic acid inhibits the release of the neurotrophic fibroblast growth factor (FGF)-1 and enhances proliferation of glia cells, in vitro. Cell Mol Neurobiol. 2005 Sep;25(6):981-93.

[3]Stone TW. Does kynurenic acid act on nicotinic receptors? An assessment of the evidence. J Neurochem. 2020 Mar;152(6):627-649. doi: 10.1111/jnc.14907. Epub 2019 Nov 24. PMID: 31693759; PMCID: PMC7078985.

[4]Swartz KJ, During MJ, Freese A, Beal MF. Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors. J Neurosci. 1990 Sep;10(9):2965-73. doi: 10.1523/JNEUROSCI.10-09-02965.1990. PMID: 2168940; PMCID: PMC6570241.

[5]Marciniak S, Wnorowski A, Smolińska K, Walczyna B, Turski W, Kocki T, Paluszkiewicz P, Parada-Turska J. Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats. Anal Cell Pathol (Amst). 2018 Sep 20;2018:1270483. doi: 10.1155/2018/1270483. PMID: 30327755; PMCID: PMC6171262.

Empirical Formula/犬尿喹啉酸 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.29mL

1.06mL

0.53mL

26.43mL

5.29mL

2.64mL

52.86mL

10.57mL

5.29mL

Empirical Formula/犬尿喹啉酸 技术信息

CAS号492-27-3
分子式C10H7NO3
分子量 189.17
SMILES Code O=C(C1=NC2=CC=CC=C2C(O)=C1)O
MDL No. MFCD00149476
别名 犬尿喹啉酸 ;Quinurenic acid; Kynurenic acid; Kynuronic acid; Kynurenate
运输蓝冰
InChI Key HCZHHEIFKROPDY-UHFFFAOYSA-N
Pubchem ID 3845
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, room temperature

Tags: Kynurenic acid | 492-27-3 | Quinurenic acid | iGluR | iGluR/α7 nAChR Antagonist | Membrane Transporter/Ion Channel | Neuronal Signaling | Metabolic Enzyme/Protease | Apoptosis | Immunology/Inflammation | GPCR/G Protein | iGluR | Endogenous Metabolite | Apoptosis | CXCR | GPR35 | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Empirical Formula/犬尿喹啉酸 纯度/质量文件 | Empirical Formula/犬尿喹啉酸 生物活性 | Empirical Formula/犬尿喹啉酸 临床数据 | Empirical Formula/犬尿喹啉酸 参考文献 | Empirical Formula/犬尿喹啉酸 实验方案 | Empirical Formula/犬尿喹啉酸 技术信息

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