Eglumegad
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货号：A163426
同义名：
LY354740; Eglumetad
LY354740 is a highly potent, efficacious and selective group II (mGlu2/3) receptor agonist, produces > 90% suppression of forskolin-stimulated cAMP formation with an EC50 of 5.1 ± 0.3 nM.
Eglumegad 化学结构
Eglumegad 3D分子结构
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Eglumegad 纯度/质量文件 产品仅供科研
货号：A163426
标准纯度：
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Eglumegad 质控信息
Eglumegad 生物活性
描述
LY354740 is a group II (mGlu2/3) metabotropic glutamate receptor agonist. It potently activates mGlu2 and mGlu3 with EC50 values of 5 and 24 nM, respectively[3] -/- mice[4] [5]
Eglumegad 参考文献
[1] Boerner T, Bygrave AM, et al. The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice. Eur J Neurosci. 2017 Apr;45(7):912-921.
[2] Orlando R, Borro M, et al. Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740. Neuropharmacology. 2014 Nov;86:133-44.
[3] Metabotropic Glutamate Receptors
[4] Boerner T, Bygrave AM, Chen J, et al. The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice. Eur J Neurosci. 2017;45(7):912-921. doi:10.1111/ejn.13539
[5] Monn JA, Valli MJ, Massey SM, et al. Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties. J Med Chem. 1997;40(4):528-537. doi:10.1021/jm9606756
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Eglumegad 实验方案
计算器
摩尔计算器
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1mg
5mg
10mg
1 mM
5 mM
10 mM
5.40mL
1.08mL
0.54mL
27.00mL
5.40mL
2.70mL
54.00mL
10.80mL
5.40mL
Eglumegad 技术信息
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