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Calcium Channel
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/ Econazole nitrate/硝酸益康唑

Econazole nitrate/硝酸益康唑 {[allProObj[0].p_purity_real_show]}

货号：A126576 同义名： SQ 13,020; NSC 243115

Econazole nitrate is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus.

Econazole nitrate/硝酸益康唑 化学结构 CAS号：24169-02-6
Econazole nitrate/硝酸益康唑 化学结构
CAS号：24169-02-6
Econazole nitrate/硝酸益康唑 3D分子结构
CAS号：24169-02-6
Econazole nitrate/硝酸益康唑 化学结构 CAS号：24169-02-6
Econazole nitrate/硝酸益康唑 3D分子结构 CAS号：24169-02-6
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Econazole nitrate/硝酸益康唑 纯度/质量文件 产品仅供科研

货号：A126576 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

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产品名称 Ca2+ channel-like protein ↓ Calcium Channel ↓ Cav 2.2 ↓ 其他靶点 纯度
CDC25B-IN-2 ✔ Akt 99%+
Clevidipine ✔ 97%
Verapamil HCl ✔ 99%
Amlodipine ✔ 99%
Amlodipine maleate ✔ 98%
(+)-cis-Diltiazem HCl ✔ 99%
Zegocractin ++

Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM

 		99%+
Tanshinone IIA sulfonate sodium ✔ 98%
Ulixacaltamide ++

hCaV3.1, IC50: 50 nM

hCaV3.2, IC50: 110 nM

 		99%+
Dronedarone HCl ✔ 95%
Nitrendipine +

Calcium channel, IC50: 95 nM

 		98%
Efonidipine HCl monoethanolate ✔ 98%
Cinnarizine ✔ 98%
SEA0400 ++

NCX, IC50: 33 nM

 		ERK,p38 MAPK,ROS 99%+
Fasudil HCl ✔ PKA,Rho 98%
ML-9 ✔ Akt,MLCK 99%+
Flunarizine 2HCl +

Calcium channel, Ki: 68 nM

 		95%
Lomerizine 2HCl ✔ 98%
Efonidipine ✔ 98%
Levamlodipine ✔ 98%
Nisoldipine ++

L-type Cav1.2, IC50: 10 nM

 		97%
Isradipine ✔ 98%
Lacidipine ✔ 98%
Lercanidipine ✔ 99%
Loureirin B ✔ Potassium Channel 99%+
Tetracaine HCl ✔ 98%
Manidipine +++

Calcium channel, IC50: 2.6 nM

 		99%
Manidipine Dihydrochlorid +++

Calcium channel, IC50: 2.6 nM

 		98%
Nicardipine ✔ 99%
Wilforgine ✔ 98+%
Econazole ✔ 99%+
Ginsenoside Rd ✔ NF-κB 98%
Fendiline HCl ✔ 98+%
Mesaconitine ✔ 98%
Tetrandrine ✔ 95%
Nifedipine ✔ 95%
Nilvadipine ++++

Calcium channel, IC50: 0.03 nM

 		98%
Barnidipine ++++

[3H]nitrendipine, Ki: 0.21 nM

 		95+%
Azelnidipine ✔ 97%
Levetiracetam ✔ 98%
Nimodipine ✔ 95%
Benidipine HCl ✔ 98%
Pinaverium bromide ✔ 98%
Pranidipine ✔ 99%
NP118809 +

N-type Ca2+ channel, IC50: 0.11 μM

L-type calcium channel, IC50: 12.2 μM

 		98%
Amlodipine Besylate +++

Calcium channel, IC50: 1.9 nM

 		97%
Cilnidipine ✔ 99%
Cinepazide Maleate ✔ 99% (HPLC)
Terfenadine ✔ 98%
YM-58483 ✔ 99%+
Ranolazine ✔ 98%
Praeruptorin A ✔ Akt,p38 MAPK 98%
Ranolazine 2HCl ✔ 98%
Felodipine ++++

L-type calcium channel, IC50: 0.15 nM

 		98%
PD173212 +++

N-type Ca2+ channel, IC50: 36 nM

 		98%
Levamlodipine besylate ✔ 97%
Carboxyamidotriazole Orotate ✔ 98%
IGS-1.76 ✔ 98+%
WH-4-023 ++++

Cav 2.2, IC50: 0.001 μM

 		++++

Cav 2.2, IC50: 0.001 μM

 		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Econazole nitrate/硝酸益康唑 生物活性

描述 Econazole Nitrate is an imidazole class antifungal medication. Vaginal candidiasis in rats was cured after oral administration of econazole. Toxicity and teratogenicity studies in different laboratory animals indicate that econazole is well tolerated[3]. Econazole nitrate loaded transethosomes are effective to deliver econazole nitrate transdermally in a controlled fashion for effective elimination of cutaneous candidiasis[4]. In acidic solutions ECN/αCD (Econazole Nitrate/α-cyclodextrin) can enhance the antifungal activity to filamentous fungi[5]. Reductions in VAS (visual analog scale) scores of econazole nitrate topical foam were significantly greater than those of ketoconazole cream, indicating the superiority of the econazole nitrate foam in reducing pruritus[6].

Econazole nitrate/硝酸益康唑 参考文献

[1]Sun J, Yu CH, et al. Econazole Nitrate Induces Apoptosis in MCF-7 Cells via Mitochondrial and Caspase Pathways. Iran J Pharm Res. 2014 Fall;13(4):1327-34.

[2]Ferrer-Villada T, Navarro-Polanco RA, et al. Inhibition of cardiac HERG potassium channels by antidepressant maprotiline. Eur J Pharmacol. 2006 Feb 15;531(1-3):1-8.

[3]hienpont D, Van Cutsem J, Van Nueten JM, Niemegeers CJ, Marsboom R. Bilogical and toxicological properties of econazole, a broad-spectrum antimycotic. Arzneimittelforschung. 1975 Feb;25(2):224-30

[4]Verma S, Utreja P. Transethosomes of Econazole Nitrate for Transdermal Delivery: Development, In-vitro Characterization, and Ex-vivo Assessment. Pharm Nanotechnol. 2018;6(3):171-179

[5]Jansook P, Prajapati M, Pruksakorn P, Loftsson T. Antifungal activity of econazole nitrate/cyclodextrin complex: Effect of pH and formation of complex aggregates. Int J Pharm. 2020 Jan 25;574:118896

[6]Hoffman LK, Raymond I, Kircik L. Treatment of Signs and Symptoms (Pruritus) of Interdigital Tinea Pedis With Econazole Nitrate Foam, 1. J Drugs Dermatol. 2018 Feb 1;17(2):229-232

Econazole nitrate/硝酸益康唑 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.25mL

0.45mL

0.22mL

11.24mL

2.25mL

1.12mL

22.49mL

4.50mL

2.25mL

Econazole nitrate/硝酸益康唑 技术信息

CAS号24169-02-6
分子式C18H16Cl3N3O4
分子量 444.7
SMILES Code ClC1=CC=C(C(OCC2=CC=C(Cl)C=C2)CN3C=CN=C3)C(Cl)=C1.O[N+]([O-])=O
MDL No. MFCD00058160
别名 SQ 13,020; NSC 243115; Econazole (nitrate)
运输蓝冰
InChI Key DDXORDQKGIZAME-UHFFFAOYSA-N
Pubchem ID 68589
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, room temperature
溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方

IP 2% DMSO+2% Tween80+40% PEG300+water 8 mg/mL clear

PO 0.5% CMC-Na 31 mg/mL suspension

Tags: Econazole | 24169-02-6 | Anti-infection | Fungal | Bacterial | Antibiotic | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Econazole nitrate/硝酸益康唑 纯度/质量文件 | Econazole nitrate/硝酸益康唑 亚型比较 | Econazole nitrate/硝酸益康唑 生物活性 | Econazole nitrate/硝酸益康唑 参考文献 | Econazole nitrate/硝酸益康唑 实验方案 | Econazole nitrate/硝酸益康唑 技术信息

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