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首页 / 抑制剂/激动剂 / 神经信号通路 / SSRIs / Duloxetine HCl/盐酸度洛西汀

Duloxetine HCl/盐酸度洛西汀 {[allProObj[0].p_purity_real_show]}

货号：A181285 同义名： LY-248686 hydrochloride; Yentreve

Duloxetine HCl is an inhibitor of serotonin-norepinephrine reuptake with Ki of 4.6 nM and used to treat depressive and anxiety disorders.

Duloxetine HCl/盐酸度洛西汀 化学结构 CAS号：136434-34-9
Duloxetine HCl/盐酸度洛西汀 化学结构
CAS号：136434-34-9
Duloxetine HCl/盐酸度洛西汀 3D分子结构
CAS号：136434-34-9
Duloxetine HCl/盐酸度洛西汀 化学结构 CAS号：136434-34-9
Duloxetine HCl/盐酸度洛西汀 3D分子结构 CAS号：136434-34-9
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Duloxetine HCl/盐酸度洛西汀 纯度/质量文件 产品仅供科研

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Duloxetine HCl/盐酸度洛西汀 生物活性

描述 Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI), used for treatment of major depressive disorder and generalized anxiety disorder (GAD). Duloxetine exhibited moderate anticonvulsive activity with an ED50 (median effective dose) of 48.21 mg/kg in the maximal electroshock test in mice.Single administration of duloxetine (6.25-25 mg/kg) significantly increased the anticonvulsant effects of valproate, carbamazepine, and oxcarbazepine in the maximal electroshock test[3]. 30 mg/kg of duloxetine could significantly inhibit the hyperexcitability of spinal wide dynamic range (WDR) cells. Duloxetine may have an effective protective action against oxaliplatin-induced neuropathic pain and spinal hyperexcitability, which is mediated by spinal α₁-adrenergic receptors[4]. Duloxetine can attenuate DR (Diabetic retinopathy) via the anti-inflammatory and the anti-oxidative properties as well as modulating the angiogenic and the neurotrophic factors expressions[5]. In vivo experiments with a mouse model of prurigo-like inflammation showed that duloxetine hydrochloride ameliorated not only scratching behaviours, but also skin inflammation. Duloxetine hydrochloride appears to be useful for treating prurigo via modulating itch signals and immune responses[6].

Duloxetine HCl/盐酸度洛西汀 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00960986 Major Depressive Disorder (MDD... 展开 >>) 收起 << Phase 4 Completed - Korea, Republic of ... 展开 >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Cheong Ju-City, Korea, Republic of, 361-711 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Goyang-Si, Korea, Republic of, 410-719 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Seongnam-Si, Korea, Republic of, 463-707 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Seoul, Korea, Republic of, 134-791 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Sungnam-Si, Korea, Republic of, 463-712 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Suwon-City, Korea, Republic of, 442-721 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Yangsan, Korea, Republic of, 626-770 收起 <<
NCT00296699 Atypical Depression Phase 4 Completed - United States, New York ... 展开 >> Depression Evaluation Service - New York State Psychiatric Institute New York, New York, United States, 10032 收起 <<
NCT01127490 Fibromyalgia Not Applicable Unknown December 2012 United States, New York ... 展开 >> Neurosciences Institute, Albany Medical College Recruiting Albany, New York, United States, 12208 Principal Investigator: Charles Argoff, MD 收起 <<

Duloxetine HCl/盐酸度洛西汀 参考文献

[1]Alarfaj NA, Ammar RA, El-Tohamy MF. Disposable screen-printed sensors for determination of duloxetine hydrochloride. Chem Cent J. 2012 Jan 21;6:6.

[2]Wong DT, Robertson DW, et al. LY227942, an inhibitor of serotonin and norepinephrine uptake: biochemical pharmacology of a potential antidepressant drug. Life Sci. 1988;43(24):2049-57.

[3]Wu Y, Huang Y, Song M, Zhang Z, Liang Z, Deng X. Anticonvulsive activity of duloxetine: A new choice for the epileptic patients with depression. Pak J Pharm Sci. 2019 May;32(3):997-1003

[4]Kim W, Chung Y, Choi S, Min BI, Kim SK. Duloxetine Protects against Oxaliplatin-Induced Neuropathic Pain and Spinal Neuron Hyperexcitability in Rodents. Int J Mol Sci. 2017 Dec 5;18(12):2626

[5]Bahr HI, Abdelghany AA, Galhom RA, Barakat BM, Arafa EA, Fawzy MS. Duloxetine protects against experimental diabetic retinopathy in mice through retinal GFAP downregulation and modulation of neurotrophic factors. Exp Eye Res. 2019 Sep;186:107742

[6]Hashimoto T, Satoh T, Yokozeki H. Prurigo successfully treated with duloxetine hydrochloride. Australas J Dermatol. 2019 Aug;60(3):237-239

Duloxetine HCl/盐酸度洛西汀 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.00mL

0.60mL

0.30mL

14.98mL

3.00mL

1.50mL

29.95mL

5.99mL

3.00mL

Duloxetine HCl/盐酸度洛西汀 技术信息

CAS号136434-34-9
分子式C18H20ClNOS
分子量 333.88
SMILES Code CNCC[C@H](OC1=C2C=CC=CC2=CC=C1)C3=CC=CS3.[H]Cl
MDL No. MFCD06407958
别名 LY-248686 hydrochloride; Yentreve; (S)-Duloxetine; Cymbalta; Duloxetine; LY248686; (S)-Duloxetine(hydrochloride); LY-248686 HCl; Duloxetine hydrochloride
运输蓝冰
InChI Key BFFSMCNJSOPUAY-LMOVPXPDSA-N
Pubchem ID 60834
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C
溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二
配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案一
动物实验配方

2% DMSO+30% PEG 300+water 20 mg/mL

Tags: Duloxetine | 136434-34-9 | (S)-Duloxetine | LY-248686 | LY248686 | LY 248686 | Serotonin-norepinephrine Reuptake Inhibitor | Neuronal Signaling | Serotonin Transporter | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Duloxetine HCl/盐酸度洛西汀 纯度/质量文件 | Duloxetine HCl/盐酸度洛西汀 生物活性 | Duloxetine HCl/盐酸度洛西汀 临床数据 | Duloxetine HCl/盐酸度洛西汀 参考文献 | Duloxetine HCl/盐酸度洛西汀 实验方案 | Duloxetine HCl/盐酸度洛西汀 技术信息

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