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/ Doxorubicin HCl/盐酸多柔比星

Doxorubicin HCl/盐酸多柔比星 {[allProObj[0].p_purity_real_show]}

货号：A130952 同义名： 盐酸阿霉素 / Hydroxydaunorubicin hydrochloride; Doxorubicin (hydrochloride)

Doxorubicin HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.

Doxorubicin HCl/盐酸多柔比星 化学结构 CAS号：25316-40-9
Doxorubicin HCl/盐酸多柔比星 化学结构
CAS号：25316-40-9
Doxorubicin HCl/盐酸多柔比星 3D分子结构
CAS号：25316-40-9
Doxorubicin HCl/盐酸多柔比星 化学结构 CAS号：25316-40-9
Doxorubicin HCl/盐酸多柔比星 3D分子结构 CAS号：25316-40-9
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Doxorubicin HCl/盐酸多柔比星 纯度/质量文件 产品仅供科研

货号：A130952 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

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产品名称 Topo I ↓ Topo II ↓ Topo IV ↓ Topoisomerase ↓ 其他靶点 纯度
Ellagic acid ✔ 98%
β-Lapachone ✔ 99%+
(s)-10-hydroxycamptothecin ✔ 98+%
Camptothecin ++

Topo I, IC50: 0.68 μM

 		98%
Betulinic acid ++

Eukaryotic topoisomerase I, IC50: 5 μM

 		98%
Topotecan ++++

Topo I (DU-145 Luc cells), IC50: 2 nM

Topo I (MCF-7 Luc cells), IC50: 13 nM

 		98%
Irinotecan HCl Trihydrate ✔ 98%
SN-38 ✔ 98%
Levofloxacin hydrate ✔ 98%
Dexrazoxane ✔ 99%+
Ofloxacin ✔ 98+%
Enoxacin ✔ 99%+
Flumequine +

Topo II, IC50: 15 μM

 		98%
Levofloxacin ✔ 97%
Etoposide ✔ 98%
Pefloxacin mesylate dihydrate ✔ 99+%
Marbofloxacin ✔ 98+%
Voreloxin HCl ✔ 98%
Mitoxantrone 2HCl ✔ PKC 98%
Nalidixic acid ✔ 98%
Doxorubicin ✔ 97%
Novobiocin sodium ✔ 95%
Amonafide ✔ 99%+
Pirarubicin ✔ 98%+
Idarubicin HCl +++

Topo II (MCF-7 cells), IC50: 3.3 ng/mL

 		99%+
Genistein ✔ EGFR 98%
Teniposide ✔ 98%
Moxifloxacin ✔ 98%
Ciprofloxacin ✔ 98%
Clinafloxacin ✔ 99%
Gatifloxacin ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Epirubicin HCl ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 Autophagy ↓ 其他靶点 纯度
SBI-0206965 +++

ULK1, IC50: 108 nM

ULK2, IC50: 711 nM

 		95%
Hydroxychloroquine sulfate ✔ 99%
Valproic acid sodium ✔ HDAC 97%
PFK-015 ++

PFKFB3, IC50: 207 nM

 		99%+
MRT68921 HCl ++++

ULK1, IC50: 2.9 nM

ULK2, IC50: 1.1 nM

 		99%+
ROC-325 ✔ 99%+
Autophinib +++

Autophagy, IC50: 40 nM

 		99%
Lys05 ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Doxorubicin HCl/盐酸多柔比星 生物活性

描述 Doxorubicin hydrochloride, a potent chemotherapeutic agent and cytotoxic anthracycline antibiotic, inhibits human DNA topoisomerase I and II with IC50 values of 0.8 µM and 2.67 µM, respectively. It diminishes the basal phosphorylation of AMPK and acetyl-CoA carboxylase, leading to the induction of apoptosis and autophagy[1][2][3].

Doxorubicin HCl/盐酸多柔比星 细胞研究

细胞系 浓度 检测类型 检测时间 活性说明 数据源
16HBE 10 μM Growth Inhibition Assay 72 h GI50=0.18 μM 24650643
1A9 Cytotoxic Assay ED50=0.02 μM 17591444
2008/MRP1 Cytotoxic Assay 5 d IC50=0.577 μM 19725578
2008/P Cytotoxic Assay 5 d IC50=0.063 μM 19725578

Doxorubicin HCl/盐酸多柔比星 动物研究

Animal study Doxorubicin hydrochloride, in animal studies, is utilized to develop models of heart failure. When administered alone, neither Doxorubicin at a dosage of 2 mg/kg nor Zoledronic acid at 100 μg/kg significantly reduces the final tumor volume compared to saline treatment. However, mice receiving a combined treatment of Doxorubicin and Zoledronic acid show significantly smaller final tumor volumes than those treated with Doxorubicin alone[6].Administering Doxorubicin (ranging from 4% to 20% concentration; via a single intrastriatal injection) demonstrates neurotoxic effects in Sprague-Dawley mice[7].Doxorubicin can be attached to gold nanoparticles (Au NPs) through pH-sensitive bonds in acidic environments, enhancing its ability to cross the blood-brain barrier. The maximum absorption wavelength for this conjugation is 528 nm[9].

Doxorubicin HCl/盐酸多柔比星 参考文献

[1]Matheson CJ, et al. Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors. Eur J Med Chem. 2020 Jul 1;197:112316.

[2]Hee-KyungRhee,et al. Synthesis, cytotoxicity, and DNA topoisomerase II inhibitory activity of benzofuroquinolinediones. Bioorg Med Chem. 2007 Feb 15;15(4):1651-8.

[3]P D Foglesong, et al. Doxorubicin inhibits human DNA topoisomerase I. Cancer Chemother Pharmacol. 1992;30(2):123-5.

[4]Nesstor Pilco-Ferreto, et al. Influence of doxorubicin on apoptosis and oxidative stress in breast cancer cell lines. Int J Oncol. 2016 Aug;49(2):753-62.

[5]Regine Lüpertz, et al. Dose- and time-dependent effects of doxorubicin on cytotoxicity, cell cycle and apoptotic cell death in human colon cancer cells. Toxicology. 2010 May 27;271(3):115-21.

[6]Penelope D Ottewell, et al. Antitumor effects of doxorubicin followed by zoledronic acid in a mouse model of breast cancer. J Natl Cancer Inst. 2008 Aug 20;100(16):1167-78.

[7]Koda LY, Van der Kooy D. Doxorubicin: a fluorescent neurotoxin retrogradely transported in the central nervous system. Neurosci Lett. 1983 Mar 28;36(1):1-8. doi: 10.1016/0304-3940(83)90476-7. PMID: 6190113. 9

[8]Kauffman MK, Kauffman ME, Zhu H, Jia Z, Li YR. Fluorescence-Based Assays for Measuring Doxorubicin in Biological Systems. React Oxyg Species (Apex). 2016;2(6):432-439. doi: 10.20455/ros.2016.873. PMID: 29707647; PMCID: PMC5921830.

Doxorubicin HCl/盐酸多柔比星 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.72mL

0.34mL

0.17mL

8.62mL

1.72mL

0.86mL

17.24mL

3.45mL

1.72mL

Doxorubicin HCl/盐酸多柔比星 技术信息

CAS号25316-40-9
分子式C27H30ClNO11
分子量 579.98
SMILES Code COC1=CC=CC2=C1C(C3=C(C(O)=C4C[C@](O)(C[C@@H](C4=C3O)O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)N)C(CO)=O)C2=O)=O.[H]Cl
MDL No. MFCD00077757
别名 盐酸阿霉素 ;Hydroxydaunorubicin hydrochloride; Doxorubicin (hydrochloride); DOX; Hydroxydaunorubicin HCl; NSC 123127; Adriamycin; Doxorubicin HCl
运输蓝冰
InChI Key MWWSFMDVAYGXBV-RUELKSSGSA-N
Pubchem ID 443939
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C
动物实验配方

PO 0.5% CMC-Na 50 mg/mL suspension

Tags: Doxorubicin HCl | Doxorubicin hydrochloride | Hydroxydaunorubicin hydrochloride;Doxorubicin (hydrochloride);DOX;Hydroxydaunorubicin HCl;NSC 123127;Adriamycin;Doxorubicin HCl | 盐酸阿霉素 | Inflammation Model | Nervous System Model | Lifestyle-related Disease Model | Anti-tumor | DNA Topoisomerase II Inhibitor | Tetracycline | Topoisomerase | Autophagy | AmBeed-信号通路专用抑制剂 | Doxorubicin HCl/盐酸多柔比星 纯度/质量文件 | Doxorubicin HCl/盐酸多柔比星 亚型比较 | Doxorubicin HCl/盐酸多柔比星 生物活性 | Doxorubicin HCl/盐酸多柔比星 细胞研究 | Doxorubicin HCl/盐酸多柔比星 动物研究 | Doxorubicin HCl/盐酸多柔比星 参考文献 | Doxorubicin HCl/盐酸多柔比星 实验方案 | Doxorubicin HCl/盐酸多柔比星 技术信息

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