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/ Dobutamine HCl/盐酸多巴酚丁胺

Dobutamine HCl/盐酸多巴酚丁胺 {[allProObj[0].p_purity_real_show]}

货号：A192909 同义名： Dobutamine (hydrochloride); Dobutrex

Dobutamine HCl is a sympathomimetic drug used in the treatment of heart failure and cardiogenic shock.

Dobutamine HCl/盐酸多巴酚丁胺 化学结构 CAS号：49745-95-1
Dobutamine HCl/盐酸多巴酚丁胺 化学结构
CAS号：49745-95-1
Dobutamine HCl/盐酸多巴酚丁胺 3D分子结构
CAS号：49745-95-1
Dobutamine HCl/盐酸多巴酚丁胺 化学结构 CAS号：49745-95-1
Dobutamine HCl/盐酸多巴酚丁胺 3D分子结构 CAS号：49745-95-1
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Dobutamine HCl/盐酸多巴酚丁胺 纯度/质量文件 产品仅供科研

货号：A192909 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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Yohimbine HCI ✔ 99+%
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Dobutamine HCl/盐酸多巴酚丁胺 生物活性

描述 Dobutamine HCl is a synthetic catecholamine that acts on alpha-1, beta-1 and beta-2 adrenergic receptors. In clinical use, dobutamine has a rapid onset of action and a short half-life[3]. Dobutamine has the capacity to stimulate beta 1-, beta 2-, and alpha 1-adrenoceptors in the cardiovascular system at doses that approximate those used clinically. Furthermore, in the vasculature, the beta 2-adrenoceptor-mediated vasodilatory effect of dobutamine is exactly offset by the alpha 1-adrenoceptor-mediated vasoconstrictor activity, such that net changes in blood pressure are minimal following the administration of dobutamine[4]. Dobutamine increased the contractility of isolated cat papillary muscles more but the automaticity less than did isoproterenol. In ischemic dog hearts, dobutamine lacked significant arrhythmic activity, whereas dopamine, norepinephrine, and isoproterenol caused severe ectopic activity[5]. Dobutamine hydrochloride (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice. Dobutamine hydrochloride results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice. In the Tgαq*44 mice low doses of dobutamine significantly increased inotropic and lusitropic cardiac performance without chronotropic changes. An increased heart rate was observed only after high doses of dobutamine, but then inotropic and lusitropic cardiac functional reserve was lost[6].

Dobutamine HCl/盐酸多巴酚丁胺 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00001314 - Completed - United States, Maryland ... 展开 >> National Heart, Lung and Blood Institute (NHLBI) Bethesda, Maryland, United States, 20892 收起 <<
NCT00338455 Congestive Heart Failure ... 展开 >> Cardiac Transplantation Renal Insufficiency Renal Failure 收起 << Phase 2 Terminated(DSMC acknowledged n... 展开 >>o safety concerns with the trial, recommending that the trial be terminated due to slow enrollment) 收起 << - United States, California ... 展开 >> Stanford, California, United States United States, Florida Tampa, Florida, United States United States, Illinois Chicago, Illinois, United States Maywood, Illinois, United States United States, Maryland Baltimore, Maryland, United States United States, Massachusetts Boston, Massachusetts, United States United States, Missouri Saint Louis, Missouri, United States United States, New York New York, New York, United States United States, Ohio Cleveland, Ohio, United States Columbus, Ohio, United States United States, Pennsylvania Philadelphia, Pennsylvania, United States United States, South Carolina Charleston, South Carolina, United States United States, Texas Houston, Texas, United States United States, Washington Seattle, Washington, United States 收起 <<
NCT00791843 Congestive Heart Failure Phase 2 Completed - United States, Massachusetts ... 展开 >> Massachusetts General Hospital/ Geriatric Research Boston, Massachusetts, United States, 02114 收起 <<

Dobutamine HCl/盐酸多巴酚丁胺 参考文献

[1]Schier MF, Raisis AL, et al. Effects of dobutamine hydrochloride on cardiovascular function in horses anesthetized with isoflurane with or without acepromazine maleate premedication. Am J Vet Res. 2016 Dec;77(12):1318-1324.

[2]Tian FS, Chen YH, et al. Determination of dobutamine hydrochloride by enzymatic catalytic spectrofluorimetry. Luminescence. 2014 Feb;29(1):92-5.

[3]Vallet B, Dupuis B, Chopin C. Dobutamine: mécanismes d'action et utilisation en pathologie cardiovasculaire aiguë [Dobutamine: mechanisms of action and use in acute cardiovascular pathology]. Ann Cardiol Angeiol (Paris). 1991;40(6):397-402

[4]Ruffolo RR Jr. The pharmacology of dobutamine. Am J Med Sci. 1987;294(4):244-248

[5]Tuttle RR, Mills J. Dobutamine: development of a new catecholamine to selectively increase cardiac contractility. Circ Res. 1975;36(1):185-196

[6]Tyrankiewicz U, Skorka T, Jablonska M, Petkow-Dimitrow P, Chlopicki S. Characterization of the cardiac response to a low and high dose of dobutamine in the mouse model of dilated cardiomyopathy by MRI in vivo. J Magn Reson Imaging. 2013;37(3):669-677

Dobutamine HCl/盐酸多巴酚丁胺 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.96mL

0.59mL

0.30mL

14.80mL

2.96mL

1.48mL

29.60mL

5.92mL

2.96mL

Dobutamine HCl/盐酸多巴酚丁胺 技术信息

CAS号49745-95-1
分子式C18H24ClNO3
分子量 337.84
SMILES Code OC1=CC=C(CCNC(C)CCC2=CC=C(O)C=C2)C=C1O.[H]Cl
MDL No. MFCD13185823
别名 Dobutamine (hydrochloride); Dobutrex; NSC 299583; Inotrex; Dobutamine hydrochloride
运输蓝冰
InChI Key BQKADKWNRWCIJL-UHFFFAOYSA-N
Pubchem ID 65324
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, room temperature
溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二
配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案一

Tags: Dobutamine | 49745-95-1 | β1-AR Agonist | GPCR/G Protein | Neuronal Signaling | Adrenergic Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Dobutamine HCl/盐酸多巴酚丁胺 纯度/质量文件 | Dobutamine HCl/盐酸多巴酚丁胺 亚型比较 | Dobutamine HCl/盐酸多巴酚丁胺 生物活性 | Dobutamine HCl/盐酸多巴酚丁胺 临床数据 | Dobutamine HCl/盐酸多巴酚丁胺 参考文献 | Dobutamine HCl/盐酸多巴酚丁胺 实验方案 | Dobutamine HCl/盐酸多巴酚丁胺 技术信息

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