Disopyramide can block sodium channel, it is a class IA antiarrhythmic drug.
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Disopyramide is a class IA antiarrhythmic drug with efficacy in ventricular and atrial arrhythmias. Disopyramide possesses a non-competitive blocking action at the neuromuscular junction, which is not reversible by anticholinesterase agents. HERG tail currents recorded at -40 mV following test pulses to +30 mV were inhibited in a dose-dependent fashion by Disopyramide concentrations within the clinical range (IC50=7.23 μM)[1]. Disopyramide inhibits multiple ion channels, leading to lower Ca transients and force, and shortens action potentials, thus reducing cellular arrhythmias[2]. Disopyramide may be effective for preventing tachyarrhythmias in SQTS1 (Short QT syndrome1)-patients carrying the N588K mutation in HERG channel by APD (action potential duration)-prolongation via enhancing ICa-L (inward L-type calcium channel current), late INa (the late sodium channel current), INCX (the Na/Ca exchanger current), and reducing ISK (outward small-conductance calcium-activated potassium channel current)[3].
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University of Calgary and Calgary Health Region
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United States, Arizona
... 展开 >>
Mayo Clinic Arizona
Scottsdale, Arizona, United States, 85259
United States, Indiana
The Heart Group
Evansville, Indiana, United States, 47710
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
United States, Oregon
Oregon Health and Science University
Portland, Oregon, United States, 97239
United States, Tennessee
Chattanooga Heart Institute
Chattanooga, Tennessee, United States, 37404
Canada, Alberta
University of Calgary and Calgary Health Region
Calgary, Alberta, Canada, T2N-4N1 收起 <<
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