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Diniconazol/烯唑醇 {[allProObj[0].p_purity_real_show]}

货号:A145773 同义名: Rac-diniconazole; Diniconazole

Diniconazole is a broad-spectrum triazole fungicide working by inhibiting ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol.

Diniconazol/烯唑醇 化学结构 CAS号:83657-24-3
Diniconazol/烯唑醇 化学结构
CAS号:83657-24-3
Diniconazol/烯唑醇 3D分子结构
CAS号:83657-24-3
Diniconazol/烯唑醇 化学结构 CAS号:83657-24-3
Diniconazol/烯唑醇 3D分子结构 CAS号:83657-24-3
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Diniconazol/烯唑醇 纯度/质量文件 产品仅供科研

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Diniconazol/烯唑醇 生物活性

描述 Diniconazole is a systemic triazole fungicide. Diniconazole disturbed energy metabolism, amino acid metabolism and lipid metabolism[3]. Under the optimized assay conditions, 50% inhibition concentration (IC50) and the limit of detection (LOD, IC10) of clothianidin were 5.08 and 0.021 μg/L, and 13.14 and 0.029 μg/L for diniconazole[4]. Diniconazole induces increases in the hepatic UDP-GT (UDP-glucuronyltransferase) activity and the thyroid hormone excretion from the liver. The thyroid tumorigenesis in rats treated with diniconazole is due to the secondary overstimulant effect on the thyroid by increased serum TSH (thyroid stimulating hormone) level[5]. In addition, the bioaccumulation of diniconazole in Tenebrio molitor was enantioselective with preferential accumulation of S-enantiomer[6].

Diniconazol/烯唑醇 参考文献

[1]Liu Z, Jin Y, Wang M. Determination of diniconazole in agricultural samples by sol-gel immunoaffinity extraction procedure coupled with HPLC and ELISA. PLoS One. 2012;7(10):e46929.

[2]Yoshida Y, Aoyama Y, et al. Stereo-selective interaction of enantiomers of diniconazole, a fungicide, with purified P-450/14DM from yeast. Biochem Biophys Res Commun. 1986 May 29;137(1):513-9.

[3]Wang Y, Zhu W, Wang D, et al. 1H NMR-based metabolomics analysis of adult zebrafish (Danio rerio) after exposure to diniconazole as well as its bioaccumulation behavior. Chemosphere. 2017;168:1571–1577

[4]Sheng E, Shi H, Zhou L, et al. Dual-labeled time-resolved fluoroimmunoassay for simultaneous detection of clothianidin and diniconazole in agricultural samples. Food Chem. 2016;192:525–530

[5]Hosokawa S, Nakamura J, Ito S, et al. Hormonal disregulation mechanism in the rat thyroid tumor induced by diniconazole. J Toxicol Sci. 1993;18(1):57–67

[6]Liu C, LV XT, Zhu WX, et al. Enantioselective bioaccumulation of diniconazole in Tenebrio molitor larvae. Chirality. 2013;25(12):917–922

Diniconazol/烯唑醇 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.07mL

0.61mL

0.31mL

15.33mL

3.07mL

1.53mL

30.65mL

6.13mL

3.07mL

Diniconazol/烯唑醇 技术信息

CAS号83657-24-3
分子式C15H17Cl2N3O
分子量 326.22
SMILES Code CC(C)(C)C(O)/C(N1N=CN=C1)=C\C2=CC=C(Cl)C=C2Cl
MDL No. MFCD01678675
别名 Rac-diniconazole; Diniconazole; Sumi; Ortho spotless; Mixor; Spotless; S-3308L; S-3308
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C

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