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Dihydrochelerythrine/二氢白屈菜红碱 {[allProObj[0].p_purity_real_show]}

货号:A475299 同义名: 12,13-Dihydrochelerythrine

Dihydrochelerythrine is a natural product isolated and purified from the herbs of Chelidonium majus, has antifungal activity against pathogenic plant fungi., and shows antiparasitic efficacy against Ichthyophthirius multifiliis in richadsin. Dihydrochelerythrine also affects cell cycle distribution, activates mitochondrial apoptotic pathway, and induces apoptosis and necrosis in HL-60 cells.

Dihydrochelerythrine/二氢白屈菜红碱 化学结构 CAS号:6880-91-7
Dihydrochelerythrine/二氢白屈菜红碱 化学结构
CAS号:6880-91-7
Dihydrochelerythrine/二氢白屈菜红碱 3D分子结构
CAS号:6880-91-7
Dihydrochelerythrine/二氢白屈菜红碱 化学结构 CAS号:6880-91-7
Dihydrochelerythrine/二氢白屈菜红碱 3D分子结构 CAS号:6880-91-7
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Dihydrochelerythrine/二氢白屈菜红碱 纯度/质量文件 产品仅供科研

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Dihydrochelerythrine/二氢白屈菜红碱 生物活性

描述 Dihydrochelerythrine is a natural compound isolated from the leaves of Macleaya microcarpa, and has antifungal activity. Dihydrochelerythrine showed the highest antifungal activity against B. cinerea Pers, with 98.32% mycelial growth inhibition at 50 μg/mL. Dihydrochelerythrine inhibited spore germination in vitro in a concentration-dependent manner[3]. Dihydrochelerythrine exhibited strong activity against methicillin-resistant Staphylococcus aureus SK1 and moderate activity against Escherichia coli TISTR 780 with MIC values of 8 and 16 μg/mL, respectively[4]. After 4h of treatment, chelerythrine induced a dose-dependent decrease in the cell viability (human promyelocytic leukemia HL-60 cells) with IC50 of 2.6 microM as shown by MTT reduction assay. Dihydrochelerythrine can affect cell cycle distribution, activate mitochondrial apoptotic pathway, and induce apoptosis and necrosis in HL-60 cells[5].

Dihydrochelerythrine/二氢白屈菜红碱 参考文献

[1]Yao JY, Zhou ZM, et al. Antiparasitic efficacy of dihydrosanguinarine and dihydrochelerythrine from Macleaya microcarpa against Ichthyophthirius multifiliis in richadsin (Squaliobarbus curriculus). Vet Parasitol. 2011 Dec 29;183(1-2):8-13.

[2]Feng G, Zhang J, Liu YQ. Inhibitory activity of dihydrosanguinarine and dihydrochelerythrine against phytopathogenic fungi. Nat Prod Res. 2011 Jul;25(11):1082-9.

[3]Feng G, Zhang J, Liu YQ. Inhibitory activity of dihydrosanguinarine and dihydrochelerythrine against phytopathogenic fungi. Nat Prod Res. 2011 Jul;25(11):1082-9

[4]Tantapakul C, Phakhodee W, Ritthiwigrom T, Yossathera K, Deachathai S, Laphookhieo S. Antibacterial compounds from Zanthoxylum rhetsa. Arch Pharm Res. 2012 Jul;35(7):1139-42

[5]Vrba J, Dolezel P, Vicar J, Modrianský M, Ulrichová J. Chelerythrine and dihydrochelerythrine induce G1 phase arrest and bimodal cell death in human leukemia HL-60 cells. Toxicol In Vitro. 2008 Jun;22(4):1008-17

Dihydrochelerythrine/二氢白屈菜红碱 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.86mL

0.57mL

0.29mL

14.31mL

2.86mL

1.43mL

28.62mL

5.72mL

2.86mL

Dihydrochelerythrine/二氢白屈菜红碱 技术信息

CAS号6880-91-7
分子式C21H19NO4
分子量 349.38
SMILES Code CN1C(C2=CC(OCO3)=C3C=C2C=C4)=C4C5=CC=C(OC)C(OC)=C5C1
MDL No. MFCD02183360
别名 12,13-Dihydrochelerythrine
运输蓝冰
InChI Key ALZAZMCIBRHMFF-UHFFFAOYSA-N
Pubchem ID 485077
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, 2-8°C

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