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Dichlorophen/双氯酚 {[allProObj[0].p_purity_real_show]}

货号:A377668 同义名: 双氯酚 / DDM; Bis(5-chloro-2-hydroxyphenyl)methane

Dichlorophen is an anticestodal agent.

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Type HazMat fee for 500 gram (Estimated)
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Dichlorophen/双氯酚 化学结构 CAS号:97-23-4
Dichlorophen/双氯酚 化学结构
CAS号:97-23-4
Dichlorophen/双氯酚 3D分子结构
CAS号:97-23-4
Dichlorophen/双氯酚 化学结构 CAS号:97-23-4
Dichlorophen/双氯酚 3D分子结构 CAS号:97-23-4
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Dichlorophen/双氯酚 纯度/质量文件 产品仅供科研

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Dichlorophen/双氯酚 生物活性

描述 Dichlorophen is a chlorophenol fungicide. Dichlorophen ingestion results in life-threatening multiorgan dysfunction including rapid onset of caustic digestive lesions, diarrhea, liver enzyme disturbances, as well as acute kidney injury and rhabdomyolysis. Recovery can be complete if prompt supportive management is provided[2]. The in vitro and in vivo efficacy of dichlorophen (DCP), an antiparasitic agent for intestinal parasites, and silica nanoparticles modified with DCP (NP-DCP) was evaluated against E. multilocularis larval stage. Both formulations showed a time and dose-dependent in vitro effect against protoscoleces. In vivo studies demonstrated that the NP-DCP (4 mg kg-1) had similar efficacy to ABZ (25 mg kg-1) and greater activity than the free DCP[3]. Dichlorophen is advocated for tape worm, but was found to reduce the ova count by 83.3% and repeat treatment completely eradicated infection with F. buski[4].

Dichlorophen/双氯酚 参考文献

[1]Shi H, Peng J, et al. Laccase-catalyzed removal of the antimicrobials chlorophene and dichlorophen from water: Reaction kinetics, pathway and toxicity evaluation. J Hazard Mater. 2016 Nov 5;317:81-89.

[2]Langrand J, Moesch C, Le Grand R, et al. A life-threatening dichlorophen poisoning case: clinical features and kinetics study. Clin Toxicol (Phila). 2013;51(3):178-181

[3]Fabbri J, Pensel PE, Albani CM, Arce VB, Mártire DO, Elissondo MC. Drug repurposing for the treatment of alveolar echinococcosis: in vitro and in vivo effects of silica nanoparticles modified with dichlorophen. Parasitology. 2019;146(13):1620-1630

[4]Idris M, Rahman KM, Muttalib MA, Azad Khan AK. The treatment of fasciolopsiasis with niclosamide and dichlorophen. J Trop Med Hyg. 1980;83(2):71-74

Dichlorophen/双氯酚 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.72mL

0.74mL

0.37mL

18.58mL

3.72mL

1.86mL

37.16mL

7.43mL

3.72mL

Dichlorophen/双氯酚 技术信息

CAS号97-23-4
分子式C13H10Cl2O2
分子量 269.12
SMILES Code OC1=CC=C(Cl)C=C1CC2=CC(Cl)=CC=C2O
MDL No. MFCD00002322
别名 双氯酚 ;DDM; Bis(5-chloro-2-hydroxyphenyl)methane; NSC 38642; Dichlorophene
运输蓝冰
InChI Key MDNWOSOZYLHTCG-UHFFFAOYSA-N
Pubchem ID 3037
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, room temperature

溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
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