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/ Deoxycholic Acid/络胆酸

Deoxycholic Acid/络胆酸 {[allProObj[0].p_purity_real_show]}

货号：A359830 同义名： 去氧胆酸 / Cholanoic Acid; Desoxycholic acid

Deoxycholic Acid is a proinflammatory agent and used in a study to investigate dose-dependent anti-inflammatory effect of ursodeoxycholic acid in experimental colitis.

Deoxycholic Acid/络胆酸 化学结构 CAS号：83-44-3
Deoxycholic Acid/络胆酸 化学结构
CAS号：83-44-3
Deoxycholic Acid/络胆酸 3D分子结构
CAS号：83-44-3
Deoxycholic Acid/络胆酸 化学结构 CAS号：83-44-3
Deoxycholic Acid/络胆酸 3D分子结构 CAS号：83-44-3
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Deoxycholic Acid/络胆酸 纯度/质量文件 产品仅供科研

货号：A359830 标准纯度： {[allProObj[0].p_purity_real_show]}
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Deoxycholic Acid/络胆酸 生物活性

描述 Deoxycholic Acid is produced by dehydrogenation of primary bile acids by intestinal bacteria. Deoxycholic Acid (1–50 μM) inhibits pacemaker currents in a dose-dependent manner in ICC (interstitial cells of Cajal ). In addition, deoxycholic acid may activate KATP channels in ICC and affect COX-2 (cyclooxygenase-2) activity [3]. Deoxycholic Acid activated EGFR (epidermal growth factor receptor) and promoted intestinal carcinogenesis by ADAM17‐dependent ligand[4].

Deoxycholic Acid/络胆酸 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02817620 Metabolic Syndrome Not Applicable Completed - France ... 展开 >> Biofortis Mérieux NutriSciences Clinical Investigation Center Saint Herblain, France, 44800 收起 <<
NCT03205176 Malignant Solid Tumors ... 展开 >> Lymphoma Ovarian Cancer 收起 << Phase 1 Recruiting July 26, 2019 United States, Florida ... 展开 >> Research Site Recruiting Sarasota, Florida, United States, 34232 United States, Oklahoma Research Site Recruiting Oklahoma City, Oklahoma, United States, 73104 United States, Tennessee Research Site Recruiting Nashville, Tennessee, United States, 37203 收起 <<
NCT03510052 Accidental Bowel Leakage ... 展开 >> Fecal Incontinence Incontinence Bowel Incontinence 收起 << Not Applicable Recruiting January 1, 2019 United States, Pennsylvania ... 展开 >> Hospital of the University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Nancy Ejike          Principal Investigator: Uduak Andy, MD 收起 <<

Deoxycholic Acid/络胆酸 参考文献

[1]Wang X, Sun L, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in mice dependent on c-Myc expression. Cancer Med. 2017 Apr;6(4):788-797.

[2]Rodrigues PM, Afonso MB, et al. Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocelular apoptosis. Sci Rep. 2015 Dec 1;5:17528.

[3]Jun JY, Choi S, Chang IY, Yoon CK, Jeong HG, Kong ID, So I, Kim KW, You HJ. Deoxycholic acid inhibits pacemaker currents by activating ATP-dependent K+ channels through prostaglandin E2 in interstitial cells of Cajal from the murine small intestine. Br J Pharmacol. 2005 Jan;144(2):242-51. doi: 10.1038/sj.bjp.0706074. PMID: 15665863; PMCID: PMC1575998.

[4]Dong W, Liu L, Dou Y, Xu M, Liu T, Wang S, Zhang Y, Deng B, Wang B, Cao H. Deoxycholic acid activates epidermal growth factor receptor and promotes intestinal carcinogenesis by ADAM17-dependent ligand release. J Cell Mol Med. 2018 Sep;22(9):4263-4273. doi: 10.1111/jcmm.13709. Epub 2018 Jun 29. PMID: 29956475; PMCID: PMC6111862.

Deoxycholic Acid/络胆酸 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.55mL

0.51mL

0.25mL

12.74mL

2.55mL

1.27mL

25.47mL

5.09mL

2.55mL

Deoxycholic Acid/络胆酸 技术信息

CAS号83-44-3
分子式C24H40O4
分子量 392.57
SMILES Code C[C@@]1([C@@]2([H])[C@H](C)CCC(O)=O)[C@](CC2)([H])[C@@](CC[C@@]3([H])[C@@]4(CC[C@@H](O)C3)C)([H])[C@]4([H])C[C@@H]1O
MDL No. MFCD00003673
别名 去氧胆酸 ;Cholanoic Acid; Desoxycholic acid; 7Deoxycholic acid Desoxycholic acid. DCA.; 312dihydroxy5cholanate; DCA; Cholorebic; Cholerebic; Deoxycholate
运输蓝冰
InChI Key KXGVEGMKQFWNSR-LLQZFEROSA-N
Pubchem ID 222528
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C

Tags: Deoxycholic Acid | Cholanoic Acid;Desoxycholic acid;7Deoxycholic acid Desoxycholic acid. DCA.;312dihydroxy5cholanate;DCA;Deoxycholic Acid MaxSpec® Standard;Cholorebic;Cholerebic;Deoxycholate | 去氧胆酸 | Other Modeling Agents | Drug Standard | GPCR | Steroids | AmBeed-信号通路专用抑制剂 | Deoxycholic Acid/络胆酸 纯度/质量文件 | Deoxycholic Acid/络胆酸 生物活性 | Deoxycholic Acid/络胆酸 临床数据 | Deoxycholic Acid/络胆酸 参考文献 | Deoxycholic Acid/络胆酸 实验方案 | Deoxycholic Acid/络胆酸 技术信息

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