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Deferoxamine Mesylate/甲磺酸去铁胺 {[allProObj[0].p_purity_real_show]}

货号：A377160 同义名： 去铁铵 / Desferrioxamine B mesylate; DFOM

Deferoxamine mesylate as a chelating agent used to remove excess iron from the body, treat acute iron poisoning, especially in small children, used to treat hemochromatosis, that can be either genetic or acquired. It has been previously reported to induce hypoxia and hypoxia-inducible factor-1α (HIF-1α) expression.

Deferoxamine Mesylate/甲磺酸去铁胺 化学结构 CAS号：138-14-7
Deferoxamine Mesylate/甲磺酸去铁胺 化学结构
CAS号：138-14-7
Deferoxamine Mesylate/甲磺酸去铁胺 3D分子结构
CAS号：138-14-7
Deferoxamine Mesylate/甲磺酸去铁胺 化学结构 CAS号：138-14-7
Deferoxamine Mesylate/甲磺酸去铁胺 3D分子结构 CAS号：138-14-7
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Deferoxamine Mesylate/甲磺酸去铁胺 纯度/质量文件 产品仅供科研

货号：A377160 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Akt ↓ Akt1 ↓ Akt2 ↓ Akt3 ↓ 其他靶点 纯度
Honokiol ✔ MEK 98%
PF-04691502 ++++

P-Akt (S473), IC50: 3.8 nM

P-Akt (T308), IC50: 7.5 nM

 		98+%
PHT-427 +

Akt, Ki: 2.7 μM

 		99%+
Deguelin ✔ PI3K 99%+
TIC10 isomer ✔ ERK 98+%
Perifosine +

Akt, IC50: 4.7 μM

 		98%
Miltefosine ✔ PI3K,PKC 98%
Triciribine +

Akt, IC50: 130 nM

 		99%+
Uprosertib +

Akt1, IC50: 180 nM

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Akt2, IC50: 328 nM

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Akt3, IC50: 38 nM

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Afuresertib ++++

Akt1, Ki: 0.08 nM

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Akt2, Ki: 2 nM

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Akt3, Ki: 2.6 nM

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Miransertib ++++

Akt1, IC50: 5 nM

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Akt2, IC50: 4.5 nM

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Akt3, IC50: 16 nM

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GSK-690693 ++++

Akt1, IC50: 2 nM

 		+++

Akt2, IC50: 13 nM

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Akt3, IC50: 9 nM

 		99%+
AT7867 ++

Akt1, IC50: 32 nM

 		++

Akt2, IC50: 17 nM

 		++

Akt3, IC50: 47 nM

 		PKA 99%+
AKT inhibitor VIII ++

Akt1, IC50: 58 nM

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Akt2, IC50: 210 nM

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Akt3, IC50: 2119 nM

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MK-2206 2HCl +++

Akt1, IC50: 8 nM

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Akt1, IC50: 5 nM

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Akt2, IC50: 18 nM

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Akt1, IC50: 38 nM

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Akt2, IC50: 402 nM

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Akt3, IC50: 50 nM

 		PKA 95%
Capivasertib ++++

Akt1, IC50: 3 nM

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Akt2, IC50: 8 nM

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Akt3, IC50: 8 nM

 		99%+
A-674563 HCl +++

Akt1, Ki: 11 nM

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CCT128930 +++

Akt2, IC50: 6 nM

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SBI-0206965 +++

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ULK2, IC50: 711 nM

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Hydroxychloroquine sulfate ✔ 99%
Valproic acid sodium ✔ HDAC 97%
PFK-015 ++

PFKFB3, IC50: 207 nM

 		99%+
MRT68921 HCl ++++

ULK1, IC50: 2.9 nM

ULK2, IC50: 1.1 nM

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ROC-325 ✔ 99%+
Autophinib +++

Autophagy, IC50: 40 nM

 		99%
Lys05 ✔ 99%+
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HIF-1α, IC50: 20 μM

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HIF-1α, IC50: 20 μM

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Lificiguat ✔ 99%+
BAY 87-2243 ✔ 99%+
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HIF, IC50: 4.4 μM

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DMOG ✔ 98%
FG 2216 ++

PHD2, IC50: 3.9 μM

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MK-8617 ++++

PHD1, IC50: 1 nM

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PHD2, IC50: 1 nM

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PHD3, IC50: 14 nM

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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Deferoxamine Mesylate/甲磺酸去铁胺 生物活性

描述 Deferoxamine mesylate as a chelating agent used to remove excess iron from the body, treat acute iron poisoning, especially in small children, used to treat hemochromatosis, that can be either genetic or acquired. It has been previously reported to induce hypoxia and hypoxia-inducible factor-1α (HIF-1α) expression.

Deferoxamine Mesylate/甲磺酸去铁胺 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00004982 Iron Overload ... 展开 >> Thalassemia 收起 << Phase 1 Completed - United States, New York ... 展开 >> Cornell University Medical College New York, New York, United States, 10021 收起 <<
NCT00447694 Beta-thalassemia ... 展开 >> Iron Overload 收起 << Phase 2 Completed - United States, California ... 展开 >> Childrens Hospital of Los Angeles Los Angeles, California, United States, 90027 Children's Hospital and Research Center at Oakland Oakland, California, United States, 94609 United States, Illinois Children's Memorial Hospital Chicago, Illinois, United States, 60614 收起 <<
NCT00110266 Myelodysplastic Syndrome ... 展开 >> Iron Overload 收起 << Phase 2 Completed - -

Deferoxamine Mesylate/甲磺酸去铁胺 参考文献

[1]Li Y, Yang H, et al. Effects of deferoxamine on blood-brain barrier disruption after subarachnoid hemorrhage. PLoS One. 2017 Mar 1;12(3):e0172784.

[2]Wahl EA, Schenck TL, et al. VEGF released by deferoxamine preconditioned mesenchymal stem cells seeded on collagen-GAG substrates enhances neovascularization. Sci Rep. 2016 Nov 10;6:36879.

Deferoxamine Mesylate/甲磺酸去铁胺 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.52mL

0.30mL

0.15mL

7.61mL

1.52mL

0.76mL

15.23mL

3.05mL

1.52mL

Deferoxamine Mesylate/甲磺酸去铁胺 技术信息

CAS号138-14-7
分子式C26H52N6O11S
分子量 656.79
SMILES Code O=C(N(CCCCCN)O)CCC(NCCCCCN(O)C(CCC(NCCCCCN(O)C(C)=O)=O)=O)=O.CS(=O)(O)=O
MDL No. MFCD00058605
别名 去铁铵 ;Desferrioxamine B mesylate; DFOM; DFX; Deferoxamine (mesylate); DFO; NSC 644468; Desferrioxamine B; Ba 33112
运输蓝冰
InChI Key IDDIJAWJANBQLJ-UHFFFAOYSA-N
Pubchem ID 62881
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, store in freezer, under -20°C

Tags: Deferoxamine | 138-14-7 | Desferrioxamine B | DFOM | Autophagy | Metabolic Enzyme/Protease | NF-κB | Immunology/Inflammation | Apoptosis | PI3K/Akt/mTOR | Autophagy | HIF/HIF Prolyl-Hydroxylase | Reactive Oxygen Species | Apoptosis | Akt | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Deferoxamine Mesylate/甲磺酸去铁胺 纯度/质量文件 | Deferoxamine Mesylate/甲磺酸去铁胺 亚型比较 | Deferoxamine Mesylate/甲磺酸去铁胺 生物活性 | Deferoxamine Mesylate/甲磺酸去铁胺 临床数据 | Deferoxamine Mesylate/甲磺酸去铁胺 参考文献 | Deferoxamine Mesylate/甲磺酸去铁胺 实验方案 | Deferoxamine Mesylate/甲磺酸去铁胺 技术信息

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