DRB
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货号：A941159
同义名：
5,6-Dichlorobenzimidazole riboside; Benzimidazole
DRB is a chemical compound that inhibits transcription elongation by RNA Polymerase II. It works as a transcription inhibitor.
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DRB 纯度/质量文件 产品仅供科研
货号：A941159
标准纯度：
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DRB 质控信息
DRB 生物活性
靶点
描述
5,6-Dichlorobenzimidazole riboside (DRB) is a nucleoside analog that inhibits various carboxyl-terminal domain kinases, including casein kinase II and cell cycle-dependent kinases (CDK), and exhibits antitumor activity. It can also trigger apoptosis[1] [2] [3] [4] [5] [6] [7]
DRB 动物研究
Animal study
5,6-Dichlorobenzimidazole riboside, administered intraperitoneally at doses of 2.0-3.0 mg/0.25 mL water twice daily for five days, does not affect the replication of the PR8 strain of influenza virus in mice[7]
DRB 参考文献
[1] Zandomeni RO. Kinetics of inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole on calf thymus casein kinase II. Biochem J. 1989 Sep 1;262(2):469-73.
[2] Yankulov K, et al. The transcriptional elongation inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase. J Biol Chem. 1995 Oct 13;270(41):23922-5.
[3] Rickert P, et al. Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases. Oncogene. 1999 Jan 28;18(4):1093-102.
[4] Schang LM. Cyclin-dependent kinases as cellular targets for antiviral drugs. J Antimicrob Chemother. 2002 Dec;50(6):779-92.
[5] te Poele RH, et al. RNA synthesis block by 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells. Oncogene. 1999 Oct 14;18(42):5765-72.
[6] Kuo YH,et al. 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) induces apoptosis in breast cancer cells through inhibiting of Mcl-1 expression. Sci Rep. 2023 Aug 3;13(1):12621
[7] Kissman H M, et al. Synthesis and biological properties of certain 5, 6-dichlorobenzimidazole ribosides. Journal of the American Chemical Society, 1957, 79(5): 1185-1188
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DRB 实验方案
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存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.13mL
0.63mL
0.31mL
15.67mL
3.13mL
1.57mL
31.33mL
6.27mL
3.13mL
DRB 技术信息
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