Cycloleucine acts as a specific blocker of S-adenosyl-methionine dependent methylation processes and antagonizes the NMDA receptor-associated glycine receptor, evidenced by a Ki value of 600 μM. It also competitively inhibits ATP: L-methionine-S-adenosyl transferase in vitro, displaying anxiolytic and cytostatic effects[1].[2].[3].[4].
Cycloleucine/环亮氨酸 动物研究
Animal study
Administered intracerebroventricularly at doses between 0.5 and 4 μg, cycloleucine enhances exploratory behavior in rats, as shown by increased time spent in open arms, more entries into open arms, and increased extreme arrivals during tests[3].Additionally, cycloleucine leads to a reduction in the weights of the thymus and spleen in both infected and control mice exposed to the Semliki Forest virus (SFV) strain A7(74)[6].
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