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Cryptotanshinone/隐丹参酮 {[allProObj[0].p_purity_real_show]}

货号：A157592 同义名： 隐丹参醌 / Cryptotanshinon; Tanshinone c

Cryptotanshinone is a potent STAT3 inhibitor (IC50 =4.6 μM) and inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells. Cryptotanshinone showed inhibitory effect on PL(pro) with IC50 value of 0.8μM and slight inhibitory effect on 3CLpro with IC50 value of 226.7μM.

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Cryptotanshinone/隐丹参酮化学结构
CAS号：35825-57-1

Cryptotanshinone/隐丹参酮 3D分子结构
CAS号：35825-57-1

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Cryptotanshinone/隐丹参酮纯度/质量文件产品仅供科研

货号：A157592 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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STAT 亚型比较

产品名称	STAT1 ↓ ↑	STAT3 ↓ ↑	STAT5 ↓ ↑	纯度
Nifuroxazide	✔			98%
Fludarabine	✔			98%
Artesunate		✔		98%
BP-1-102		+++ STAT3, Kd: 504 nM		99%+
Niclosamide		++ STAT3, IC50: 0.7 μM		98%
Napabucasin		✔		98%
Cryptotanshinone		++ STAT3, IC50: 4.6 μM		98%
Stattic		+ STAT3, IC50: 5.1 μM		98%
NSC 74859		+ STAT3, IC50: 86 μM		99%+
Ochromycinone		✔		98%
HO-3867		✔		97%
C188-9		++++ STAT3, Kd: 4.7 nM		99%+
HJC0152		✔		99%
SH5-07		✔		97%
SH-4-54		++++ STAT3, Kd: 300 nM	+++ STAT5, Kd: 464 nM	99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Cryptotanshinone/隐丹参酮生物活性

靶点	STAT3 STAT3, IC50:4.6 μM STAT3 STAT3, IC50:4.6 μM STAT3 STAT3, IC50:4.6 μM
描述	Cryptotanshinone, a compound derived from the root of Salvia miltiorrhiza Bunge, exhibits antitumor properties. It inhibits STAT3 with an IC50 of 4.6 μM.

Cryptotanshinone/隐丹参酮细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源
human AGS cells		Function assay	16 h	Inhibition of HIF1 activation in human AGS cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay, IC50=1.58 μM	17583950
human AGS cells		Growth inhibition assay	24 h	Viability of human AGS cells under hypoxic conditions after 24 hrs by MTT assay, IC50=10.2 μM	17583950
human HCT116 cells		Function assay	24 h	Inhibition of STAT3 expressed in human HCT116 cells after 24 hrs by luciferase reporter gene assay, ic50=4.6 μM	22650325
human HeLa cells		Growth inhibition assay	24 h	Growth inhibition of human HeLa cells after 24 hrs	23957426

Cryptotanshinone/隐丹参酮动物研究

Dose

Rat: 5.7 mg/kg^[3] (p.o.), 60 mg/kg^[4] (i.v.); 17.8 mg/kg - 1080 mg/kg^[4] (p.o.) Ob/ob mice: 200 mg/kg - 600 mg/kg^[2] (p.o.) Dog: 53.4 mg/kg^[4] (i.v.)

Administration

p.o., i.v.

Pharmacokinetics

Animal	Rats^[3]
Dose	5.7 mg/kg
Administration	i.g.
t_1/2λz	170.5 ± 30.3 min
CL_λz/F	3.6 ± 1.5 l/(min·kg)
T_max	33.3 ± 8.2 min
C_max	6.5 ± 2.2 g/l
AUC_0→∞	2595.8 ± 394.8 g/(min·l)
AUC_0→t	2553.4 ± 399.8 g/(min·l)

Cryptotanshinone/隐丹参酮参考文献

[1]Shin DS, Kim HN, et al. Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res. 2009 Jan 1;69(1):193-202.

[2]Kim EJ, Jung SN, et al. Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase. Mol Pharmacol. 2007 Jul;72(1):62-72.

[3]Song M, Hang TJ, et al. Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat. Eur J Pharm Sci. 2007 Dec;32(4-5):247-53. Epub 2007 Aug 15.

[4]Pan Y, Bi HC, et al. Pharmacokinetic characterization of hydroxylpropyl-beta-cyclodextrin-included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza). Xenobiotica. 2008 Apr;38(4):382-98.

Cryptotanshinone/隐丹参酮实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.37mL

0.67mL

0.34mL

16.87mL

3.37mL

1.69mL

33.74mL

6.75mL

3.37mL

Cryptotanshinone/隐丹参酮技术信息

CAS号	35825-57-1
分子式	C₁₉H₂₀O₃
分子量	296.36
SMILES Code	O=C(C1=C2C=CC3=C1CCCC3(C)C)C(C4=C2OC[C@@H]4C)=O

别名	隐丹参醌 ;Cryptotanshinon; Tanshinone c
运输	蓝冰
InChI Key	GVKKJJOMQCNPGB-JTQLQIEISA-N
Pubchem ID	160254

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, 2-8°C

动物实验配方

5% DMSO+40%PEG 300+5% Tween80 +water 1.25 mg/mL

细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源

human AGS cells		Function assay	16 h	Inhibition of HIF1 activation in human AGS cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay, IC50=1.58 μM	17583950
human AGS cells		Growth inhibition assay	24 h	Viability of human AGS cells under hypoxic conditions after 24 hrs by MTT assay, IC50=10.2 μM	17583950
human HCT116 cells		Function assay	24 h	Inhibition of STAT3 expressed in human HCT116 cells after 24 hrs by luciferase reporter gene assay, ic50=4.6 μM	22650325
human HeLa cells		Growth inhibition assay	24 h	Growth inhibition of human HeLa cells after 24 hrs	23957426
human Hep3B cells		Function assay	16 h	Inhibition of HIF1 activation in human Hep3B cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay, IC50=1.36 μM	17583950
human HepG2 cells		Cytotoxic assay		Cytotoxicity against human HepG2 cells by MTT assay	16038550
human KB-3-1 cells		Cytotoxic assay	48 h	Cytotoxicity against drug-sensitive human KB-3-1 cells after 48 hrs by MTS/PMS assay, IC50=6.9 μM	11720520
human KBV1 cells		Cytotoxic assay	48 h	Cytotoxicity against multidrug-resistant human KBV1 cells after 48 hrs by MTS/PMS assay, IC50=7.5 μM	11720520
human MIAPaCa2 cells		Cytotoxic assay	24 h	Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay, IC50=5.8 μM	21775156
human OVCAR-3 cells		Cytotoxic assay		Cytotoxicity against human OVCAR-3 cells by MTT assay	16038550
human PBMC		Function assay		Inhibition of phytohemagglutininin A-stimulated human PBMC proliferation assessed as decrease in [14C]thymidine incorporation, IC50=37.4 μM	11720520
human THLE3 cells		Cytotoxic assay		Cytotoxicity against human THLE3 cells by MTT assay, EC50=22.9 μM	20455578
mouse Ba/F3 cells	30 μM	Function assay	3 h	Inhibition of IL3-induced SHP2-Gab2 interaction in mouse Ba/F3 cells pretreated at 30 uM for 3 hrs prior IL3 stimulation by immunoblotting method	23957426
PTPN11 E76K/+ MEF	20 μM	Growth inhibition assay		Growth inhibition of PTPN11 E76K/+ MEF at 20 uM	23957426

Cryptotanshinone/隐丹参酮 {[allProObj[0].p_purity_real_show]}

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Cryptotanshinone/隐丹参酮质控信息

Cryptotanshinone/隐丹参酮生物活性

Cryptotanshinone/隐丹参酮细胞研究

Cryptotanshinone/隐丹参酮动物研究

Cryptotanshinone/隐丹参酮参考文献

Cryptotanshinone/隐丹参酮实验方案

Cryptotanshinone/隐丹参酮技术信息

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STAT3	STAT3, IC50:4.6 μM
STAT3	STAT3, IC50:4.6 μM
STAT3	STAT3, IC50:4.6 μM

Cryptotanshinone/隐丹参酮 {[allProObj[0].p_purity_real_show]}

Cryptotanshinone/隐丹参酮 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Cryptotanshinone/隐丹参酮 质控信息

Cryptotanshinone/隐丹参酮 生物活性

Cryptotanshinone/隐丹参酮 细胞研究

Cryptotanshinone/隐丹参酮 动物研究

Cryptotanshinone/隐丹参酮 参考文献

Cryptotanshinone/隐丹参酮 实验方案

Cryptotanshinone/隐丹参酮 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Cryptotanshinone/隐丹参酮纯度/质量文件产品仅供科研

Cryptotanshinone/隐丹参酮质控信息

Cryptotanshinone/隐丹参酮生物活性

Cryptotanshinone/隐丹参酮细胞研究

Cryptotanshinone/隐丹参酮动物研究

Cryptotanshinone/隐丹参酮参考文献

Cryptotanshinone/隐丹参酮实验方案

Cryptotanshinone/隐丹参酮技术信息