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Clarithromycin/克拉霉素 {[allProObj[0].p_purity_real_show]}

货号:A155509 同义名: 克拉红霉素;6氧甲基红霉素 / A-56268; TE 031

Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor.

Clarithromycin/克拉霉素 化学结构 CAS号:81103-11-9
Clarithromycin/克拉霉素 化学结构
CAS号:81103-11-9
Clarithromycin/克拉霉素 3D分子结构
CAS号:81103-11-9
Clarithromycin/克拉霉素 化学结构 CAS号:81103-11-9
Clarithromycin/克拉霉素 3D分子结构 CAS号:81103-11-9
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Clarithromycin/克拉霉素 纯度/质量文件 产品仅供科研

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Clarithromycin/克拉霉素 生物活性

描述 Clarithromycin exhibits a wide range of antimicrobial effects and is known for its capability to inhibit the CYP3A4 enzyme, which catalyzes the alpha-hydroxylation of triazolam, demonstrating an IC50 (Ki) value of 56 (43) µM[1]. This antibiotic also significantly blocks the HERG potassium current in a concentration-dependent manner, with an IC50 of 45.7 µM[2]. Clarithromycin impacts autophagic flux by disrupting the signaling pathway that connects hERG1 and PI3K[3].

Clarithromycin/克拉霉素 动物研究

Animal study Additionally, Clarithromycin at a dose of 200 mg/kg exhibits efficacy against four in vivo tested pathogens[5], further highlighting its broad-spectrum antimicrobial activity[4].

Clarithromycin/克拉霉素 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01159574 Multiple Myeloma Phase 2 Active, not recruiting June 2020 United States, New York ... 展开 >> Weill Cornell Medical College New York, New York, United States, 10065 收起 <<
NCT03487562 Healthy Phase 1 Recruiting August 29, 2018 Korea, Republic of ... 展开 >> Seoul National University Hospital Recruiting Seoul, Korea, Republic of Contact: In-Jin Jang, MD, PhD    82-2-2072-1666    ijjang@snu.ac.kr    Principal Investigator: In-Jin Jang, MD, PhD 收起 <<
NCT01559935 - Active, not recruiting - -

Clarithromycin/克拉霉素 参考文献

[1]X J Zhao, et al. An in vitro study on the metabolism and possible drug interactions of rokitamycin, a macrolide antibiotic, using human liver microsomes. Drug Metab Dispos. 1999 Jul;27(7):776-85.

[2]Scott J C Stanat, et al. Characterization of the inhibitory effects of erythromycin and clarithromycin on the HERG potassium channel. Mol Cell Biochem. 2003 Dec;254(1-2):1-7.

[3]Giulia Petroni, et al. Clarithromycin inhibits autophagy in colorectal cancer by regulating the hERG1 potassium channel interaction with PI3K. Cell Death Dis. 2020 Mar 2;11(3):161.

[4]S P Klemens, et al. Activity of clarithromycin against Mycobacterium avium complex infection in beige mice. Antimicrob Agents Chemother. 1992 Nov;36(11):2413-7.

Clarithromycin/克拉霉素 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.34mL

0.27mL

0.13mL

6.68mL

1.34mL

0.67mL

13.37mL

2.67mL

1.34mL

Clarithromycin/克拉霉素 技术信息

CAS号81103-11-9
分子式C38H69NO13
分子量 747.95
SMILES Code C[C@@](C[C@@H](C)C([C@@H]1C)=O)([C@H](O[C@@]([H])([C@@H]2O)O[C@@H](C[C@@H]2N(C)C)C)[C@@H](C)[C@H](O[C@@]([H])(C[C@]3(OC)C)O[C@H]([C@@H]3O)C)[C@@H](C)C(O[C@@H]([C@@](O)([C@@H]1O)C)CC)=O)OC
MDL No. MFCD00865140
别名 克拉红霉素;6氧甲基红霉素;6-0-甲基红霉素A;甲红霉素;甲氧基红霉素;克红霉素 ;A-56268; TE 031; Antibiotic A 56268
运输蓝冰
InChI Key AGOYDEPGAOXOCK-KCBOHYOISA-N
Pubchem ID 84029
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C

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