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/ Chondroitin sulfate/硫酸软骨素

Chondroitin sulfate/硫酸软骨素 {[allProObj[0].p_purity_real_show]}

货号：A801789 同义名： 硫酸软骨素（鲨鱼） / Chondroitin polysulfate

Chondroitin Sulfate is a glycosaminoglycan considered as a symptomatic slow-acting drug for osteoarthritis (SYSADOA).

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Chondroitin sulfate/硫酸软骨素 化学结构 CAS号：9007-28-7
Chondroitin sulfate/硫酸软骨素 化学结构
CAS号：9007-28-7
Chondroitin sulfate/硫酸软骨素 3D分子结构
CAS号：9007-28-7
Chondroitin sulfate/硫酸软骨素 化学结构 CAS号：9007-28-7
Chondroitin sulfate/硫酸软骨素 3D分子结构 CAS号：9007-28-7
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Chondroitin sulfate/硫酸软骨素 纯度/质量文件 产品仅供科研

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Chondroitin sulfate/硫酸软骨素 生物活性

描述 Chondroitin sulfate (CS), a type of glycosaminoglycan (GAG), is a linear acidic polysaccharide comprised of repeating disaccharides, modified with sulfate groups at various positions[1]. Chondroitin Sulfate is a glycosaminoglycan considered as a symptomatic slow-acting drug for osteoarthritis (SYSADOA). Chondroitin sulfate occurs naturally in the extracellular matrix of connective tissues, e.g., bone, cartilage, skin, ligaments and tendons. Chondroitin sulfate has been shown to elicit a range of beneficial effects: anti-inflammatory effects, an increase in type II collagen and proteoglycans, a reduction in bone resorption and a better anabolic/catabolic balance in chondrocytes[2]. Chondroitin sulfate is a proteoglycan component of the extracellular matrix (ECM) that supports neuronal and non-neuronal cell activity, provides a negative domain to the extracellular matrix, regulates the intracellular positive ion concentration, and maintains the hypersynchronous epileptiform activity. Treatment with valproate (110 mg/kg; i.p.) as a standard drug and chondroitin sulfate (100 & 200 mg/kg, p.o.) significantly and dose-dependently prevented the severity of kindled and spontaneous recurrent seizures in mice. Additionally, chondroitin sulfate showed the neuroprotective effect as well as the suppressed levels of caspase-3, which indicated a neuroprotective treatment strategy in epilepsy[3].

Chondroitin sulfate/硫酸软骨素 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02658253 Malaria Phase 1 Active, not recruiting September 30, 2019 Burkina Faso ... 展开 >> CNRFP Ouagadougou, Burkina Faso, BP 2208 France CIC 1417 Paris, France, 75679 收起 <<
NCT03713112 Deprescribing ... 展开 >> Multi-disciplinary Rounds 收起 << Not Applicable Recruiting August 20, 2019 Singapore ... 展开 >> Bright Vision Hospital Recruiting Singapore, Singapore, 547530 Contact: Wong Peng Yong, Andrew, MBBS    62485755 ext 5749    med10056@yahoo.co.uk    Contact: Belinda Soh Qimin    62485755    belinda.soh@bvh.org.sg    Sub-Investigator: Charissa Ann Ee Jia Ming          Sub-Investigator: Tan Wanting          Sub-Investigator: Low Lian Leng, MBBS          Principal Investigator: Wong Peng Yong, Andrew, MBBS 收起 <<
NCT00712244 - Completed - -

Chondroitin sulfate/硫酸软骨素 参考文献

[1]Hatano S, Watanabe H. Regulation of Macrophage and Dendritic Cell Function by Chondroitin Sulfate in Innate to Antigen-Specific Adaptive Immunity. Front Immunol. 2020 Mar 3;11:232

[2]Chondroitin sulfate has been shown to elicit a range of beneficial effects: anti-inflammatory effects, an increase in type II collagen and proteoglycans, a reduction in bone resorption and a better anabolic/catabolic balance in chondrocytes

[3]Singh S, Singh TG, Singh M, Najda A, Nurzyńska-Wierdak R, Almeer R, Kamel M, Abdel-Daim MM. Anticonvulsive Effects of Chondroitin Sulfate on Pilocarpine and Pentylenetetrazole Induced Epileptogenesis in Mice. Molecules. 2021 Nov 9;26(22):6773

Chondroitin sulfate/硫酸软骨素 技术信息

CAS号9007-28-7
SMILES Code NONE
MDL No. MFCD00146419
别名 硫酸软骨素（鲨鱼） ;Chondroitin polysulfate
运输蓝冰
InChI Key KXKPYJOVDUMHGS-OSRGNVMNSA-N
Pubchem ID 24766
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, 2-8°C
溶解方案 配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案一

Tags: Chondroitin sulfate | Chondroitin polysulfate | 硫酸软骨素（鲨鱼） | Plant Standard | AmBeed-信号通路专用抑制剂 | Chondroitin sulfate/硫酸软骨素 纯度/质量文件 | Chondroitin sulfate/硫酸软骨素 生物活性 | Chondroitin sulfate/硫酸软骨素 临床数据 | Chondroitin sulfate/硫酸软骨素 参考文献 | Chondroitin sulfate/硫酸软骨素 技术信息

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