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/ Ceruletide/雨蛙素

Ceruletide/雨蛙素 {[allProObj[0].p_purity_real_show]}

货号：A569478 同义名： Cerulein; Caerulein

Ceruletide is a ten amino acid oligopeptide that stimulates smooth muscle and increases digestive secretions.

Ceruletide/雨蛙素 化学结构 CAS号：17650-98-5
Ceruletide/雨蛙素 化学结构
CAS号：17650-98-5
Ceruletide/雨蛙素 3D分子结构
CAS号：17650-98-5
Ceruletide/雨蛙素 化学结构 CAS号：17650-98-5
Ceruletide/雨蛙素 3D分子结构 CAS号：17650-98-5
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Ceruletide/雨蛙素 纯度/质量文件 产品仅供科研

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Ceruletide/雨蛙素 生物活性

描述 Cholecystokinin octapeptide (cholecystokinin-8) is found in the peripheral tissue and central nervous system (CNS). It is becoming clear that cholecystokinin-8 sulphate may function as a neurotransmitter or neuromodulator in the CNS. Thus, cholecystokinin-8 sulphate is released from synaptic vesicles in a calcium-dependent manner, binds to specific high affinity cholecystokinin receptors and exerts primarily excitatory effect on CNS neurons. One potential role that has been proposed for cholecystokinin is the modulation of central opiate nociceptive mechanism. Cholecystokinin receptors are generally divided into two classes, cholecystokinin-A (alimentary) and cholecystokin- in-B (brain)[3]. Caerulein is a decapeptide isolated from frog skin, which has been shown to possess the same biological and pharmacological activities as cholecystokinin-8[3]. Ceruletide in supramaximal but not in physiological doses activated NF-kappaB/Rel in vitro. This activation might induce a self-defending genetic program before the onset of cellular injury, which might prevent higher degrees of damage of pancreatic acinar cells after secretagogue hyperstimulation[4]. Ceruletide serum bile acid (SBA) stimulation circumvented exogenous and endogenous influences associated with postprandial (PP) SBA stimulation. Ceruletide SBA stimulation might perform as well as PP SBA stimulation in dogs with portosystemic shunt (PSS) and be more sensitive for the detection of hepatic dysfunction in dogs with upper respiratory disease (URD)[5]. Ceruletide (0.4-0.5 mcg/kg, i.v.; 3-4 mcg/kg, s.c.) resulted in emesis and evacuation of the bowel in the intact conscious dog, and recovery was complete 15 - 30 min after i. v. administration and 2 - 4h after s.c. administration. Ceruletide (5 - 15 ng/kg, i.v.) showed a marked spasmogenic effect on the pylorus of rats. Ceruletide also reduced blood pressure in anesthetized dogs[6].

Ceruletide/雨蛙素 动物研究

Dose Mice: 1 μg/kg - 300 μg/kg[3] (i.p.); 0.01 mg/kg - 0.1 mg/kg[4] (s.c.)
Administration i.p.

Ceruletide/雨蛙素 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03748667 - Not yet recruiting December 2020 United States, California ... 展开 >> San Francisco Veterans Affairs Medical Center. University of California Not yet recruiting San Francisco, California, United States, 94121 Contact       endoresection@me.com    Principal Investigator: Tonya Kaltenbach          United States, North Carolina University of North Carolina Not yet recruiting Chapel Hill, North Carolina, United States, 27599 Contact       mcgills@email.unc.edu    Principal Investigator: Sarah McGill          Japan National Cancer Center Not yet recruiting Tokyo, Japan, 104-0045 Contact       tasakamo529@gmail.com    Principal Investigator: Taku Sakamoto          Spain Hospital Clínico Universitario Lozano Blesa Not yet recruiting Zaragoza, Aragón, Spain, 50009 Contact       angel.ferrandez@telefonica.net    Principal Investigator: Ángel Ferrández          Hospital Universitari Germans Trias i Pujol (Can Ruti) Not yet recruiting Badalona, Cataluña, Spain, 08916 Contact       hugoikuo@gmail.com    Principal Investigator: Hugo Uchima          Hospital Clínic de Barcelona Not yet recruiting Barcelona, Cataluña, Spain, 08036 Contact       MPELLISE@clinic.cat    Principal Investigator: Maria Pellisé          Sub-Investigator: Miriam Cuatrecasas          Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Not yet recruiting Barcelona, Cataluña, Spain, 08036 Contact       JCAMPS@clinic.cat    Sub-Investigator: Jordi Camps          Althaia. Xarxa Assistencial Universitària de Manresa Not yet recruiting Manresa, Cataluña, Spain, 08243 Contact       orosinol@althaia.cat    Sub-Investigator: Òria Rosiñol          Hospital Universitario y Politécnico de La Fe Not yet recruiting Valencia, Comunidad Valenciana, Spain, 46009 Contact       mbustamantebalen@gmail.com    Principal Investigator: Marco Bustamante          Complejo Hospitalario de Navarra Not yet recruiting Pamplona, Navarra, Spain, 31008 Contact       edualbeniz@hotmail.com    Principal Investigator: Eduardo Albéniz          Hospital Ramón y Cajal Not yet recruiting Madrid, Spain, 28034 Contact       enrodesan@gmail.com    Principal Investigator: Enrique Rodríguez          Hospital 12 de Octubre Not yet recruiting Madrid, Spain, 28041 Contact       josecarlos.marin@salud.madrid.org    Principal Investigator: José Carlos Marín 收起 <<
NCT01491178 - Completed - -
NCT02808403 - Recruiting April 30, 2022 -

Ceruletide/雨蛙素 参考文献

[1]Furuyama T, Tanaka S, et al. Proteasome activity is required for the initiation of precancerous pancreatic lesions. Sci Rep. 2016 May 31;6:27044.

[2]Pradel P, Estival A, et al. Caerulein and gastrin(2-17 ds) regulate differently synthesis of secretory enzymes, mRNA levels and cell proliferation in pancreatic acinar cells (AR4-2J). Biochem J. 1993 Feb 15;290 ( Pt 1):219-24.

[3]Zarrindast MR, Malekzadeh A, Rezayat M, Ghazi-Khansari M. Effects of cholecystokinin receptor agonist and antagonists on morphine dependence in mice. Pharmacol Toxicol. 1995 Dec;77(6):360-4. doi: 10.1111/j.1600-0773.1995.tb01042.x. PMID: 8835359.

[4]Steinle AU, Weidenbach H, Wagner M, Adler G, Schmid RM. NF-kappaB/Rel activation in cerulein pancreatitis. Gastroenterology. 1999 Feb;116(2):420-30. doi: 10.1016/s0016-5085(99)70140-x. PMID: 9922324.

[5]Bridger N, Glanemann B, Neiger R. Comparison of postprandial and ceruletide serum bile acid stimulation in dogs. J Vet Intern Med. 2008 Jul-Aug;22(4):873-8. doi: 10.1111/j.1939-1676.2008.0114.x. PMID: 18537882.

[6]Vincent ME, Wetzner SM, Robbins AH. Pharmacology, clinical uses, and adverse effects of ceruletide, a cholecystokinetic agent. Pharmacotherapy. 1982 Jul-Aug;2(4):223-34. doi: 10.1002/j.1875-9114.1982.tb03189.x. PMID: 6763205.

Ceruletide/雨蛙素 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.74mL

0.15mL

0.07mL

3.70mL

0.74mL

0.37mL

7.39mL

1.48mL

0.74mL

Ceruletide/雨蛙素 技术信息

CAS号17650-98-5
分子式C58H73N13O21S2
分子量 1352.4
SMILES Code O=C(O)C[C@@H](C(N[C@@H](CC1=CC=CC=C1)C(N)=O)=O)NC([C@H](CCSC)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(CNC([C@H]([C@H](O)C)NC([C@H](CC4=CC=C(OS(=O)(O)=O)C=C4)NC([C@@H](NC([C@@H](NC([C@H](CC5)NC5=O)=O)CCC(N)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O
MDL No. MFCD00076478
别名 Cerulein; Caerulein; CCRIS-3063; FI-6934
运输蓝冰
InChI Key YRALAIOMGQZKOW-HYAOXDFASA-N
Pubchem ID 16129675
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, store in freezer, under -20°C
溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二
配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

Tags: Ceruletide | 17650-98-5 | Caerulein | Cerulein | FI-6934 | FI6934 | FI 6934 | FI-6934 | Cholecystokinin Receptor Agonist | Induced Disease Models Products | GPCR/G Protein | Neuronal Signaling | Immunology and Inflammatory Disease Models | Digestive System Disease Models | Cholecystokinin Receptor | Pancreatitis Models | Pancreatic Disease Models | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Ceruletide/雨蛙素 纯度/质量文件 | Ceruletide/雨蛙素 生物活性 | Ceruletide/雨蛙素 动物研究 | Ceruletide/雨蛙素 临床数据 | Ceruletide/雨蛙素 参考文献 | Ceruletide/雨蛙素 实验方案 | Ceruletide/雨蛙素 技术信息

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