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Cephradine/头孢拉定 {[allProObj[0].p_purity_real_show]}

货号:A114890 同义名: Cefradine; SQ-11436

Cefradine is a first-generation cephalosporin antibiotic with a spectrum of activity similar to Cefalexin.

Cephradine/头孢拉定 化学结构 CAS号:38821-53-3
Cephradine/头孢拉定 化学结构
CAS号:38821-53-3
Cephradine/头孢拉定 3D分子结构
CAS号:38821-53-3
Cephradine/头孢拉定 化学结构 CAS号:38821-53-3
Cephradine/头孢拉定 3D分子结构 CAS号:38821-53-3
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Cephradine/头孢拉定 纯度/质量文件 产品仅供科研

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Cephradine/头孢拉定 生物活性

描述 Cefradine is a major group of widely used β-lactam antibiotics[3]. The specific growth rate of C. reinhardtii slightly increased with cefradine concentrations within the range 0.5 - 10 mg/L[4]. Cefradine can inhibit SUV-induced (ultraviolet) skin inflammation by blocking TOPK (T-LAK cell-originated protein kinase) signaling pathway, and TOPK is an effective target for suppressing inflammation induced by SUV irradiation[5]. After a single bolus injection of two grams of cefradine the concentrations of antibiotic in serum and renal tissues of 21 patients were estimated. The estimated cefradine concentrations in serum and in normal and impaired renal tissue within the time interval of 10 to 90 minutes are above the minimal inhibition concentrations for most cefradine sensitive pathogens[6].

Cephradine/头孢拉定 参考文献

[1]Han HK, Rhie JK, et al. CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs. J Pharm Sci. 1999 Mar;88(3):347-50.

[2]Hassert GL, DeBaecke PJ, et al. Toxicological, pathological, and teratological studies in animals with cephradine. Antimicrob Agents Chemother. 1973 Jun;3(6):682-5.

[3]Dudkowska J, Frańska M, Frański R. Detection of the iron complexes with hydrolysis products of cephalexin and cefradine upon high-performance liquid chromatography/electrospray ionization mass spectrometry analysis. Rapid Commun Mass Spectrom. 2018;32(7):576–582

[4]Cao J, Jiang R, Wang J, et al. Study on the interaction mechanism between cefradine and Chlamydomonas reinhardtii in water solutions under dark condition. Ecotoxicol Environ Saf. 2018;159:56–62

[5]Fan X, Duan Q, Ke C, et al. Cefradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of T-LAK cell-originated protein kinase. Oncotarget. 2016;7(17):24633–24645

[6]Adam D, Tunn U. Konzentrationen von Cefradin im Nierengewebe [Concentrations of cefradine in renal tissue (author's transl)]. MMW Munch Med Wochenschr. 1979;121(42):1367–1369

Cephradine/头孢拉定 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.86mL

0.57mL

0.29mL

14.31mL

2.86mL

1.43mL

28.62mL

5.72mL

2.86mL

Cephradine/头孢拉定 技术信息

CAS号38821-53-3
分子式C16H19N3O4S
分子量 349.4
SMILES Code O=C(C(N12)=C(C)CS[C@]2([H])[C@H](NC([C@H](N)C3=CCC=CC3)=O)C1=O)O
MDL No. MFCD00865048
别名 Cefradine; SQ-11436; Velosef; Cephradin; Anspor; Sefril
运输蓝冰
InChI Key RDLPVSKMFDYCOR-UEKVPHQBSA-N
Pubchem ID 38103
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, 2-8°C

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