Cephalomannine, a natural product isolated and purified from the barks of Cephalotaxus sinensis (Rehd. et Wils.) Li, is a taxol derivative with antitumor, antiproliferative properties.
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Cephalomannine is an alkaloidal analog of Paclitaxel, derived from various Cephalotaxus species. It functions as an orally active anti-tumor agent and is employed in chemotherapy for cancer research[1][2][3].
Cephalomannine/三尖杉宁碱 动物研究
Animal study
In vivo, Cephalomannine administered at a dose of 0.4 mg/kg through intraperitoneal injection over a span of 10 days significantly curtails the growth of lung cancer cells in a nude mouse xenograft model, all while exhibiting no apparent side effects[3].The mechanism by which Cephalomannine operates includes disrupting the interaction between APEX1 and HIF-1α through competitive binding with APEX1, highlighting its potential therapeutic action in tumor environments, particularly under hypoxic conditions[3].
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