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Cefixime/头孢克肟 {[allProObj[0].p_purity_real_show]}

货号：A467731 同义名： FK-027; FR-17027

Cefixime is a third-generation cephalosporin antibiotic which is highly stable in the presence of β-lactamase enzymes.

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Excepted Quantity	USD 0.00
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Cefixime/头孢克肟化学结构
CAS号：79350-37-1

Cefixime/头孢克肟 3D分子结构
CAS号：79350-37-1

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Cefixime/头孢克肟纯度/质量文件产品仅供科研

货号：A467731 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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Cefixime/头孢克肟生物活性

描述	Cefixime (FR-17027) is an orally active third-generation cephalosporin antibiotic, effective for treating various bacterial infections^[1].^[2].

Cefixime/头孢克肟动物研究

Animal study

In animal studies, Cefixime administered at doses of 0.75-60 mg/kg via oral gavage reduces the bacterial burden in mice challenged with an ESC-susceptible strain of bacteria (FA1090)^[4]. Additionally, dosages of 50 or 150 mg/kg, given via oral gavage, alter the structure and abundance of the gut microbiota in C57BL/6J mice, leading to reduced diversity within the microbial community and a predominance of the Firmicutes phylum^[5].

Cefixime/头孢克肟临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00926796	Gonorrhoea	Phase 4	Completed	-	United States, Alabama ... 展开 >> University of Alabama Hospital - Infectious Diseases Birmingham, Alabama, United States, 35249-0001 United States, California Los Angeles County Department of Public Health - Sexually Transmitted Disease Program Los Angeles, California, United States, 90007-2608 San Francisco Department of Public Health - San Francisco City Clinic San Francisco, California, United States, 94103-4030 United States, Maryland Johns Hopkins Bayview Medical Center - Infectious Diseases Baltimore, Maryland, United States, 21224-2735 United States, Pennsylvania Magee Women's Hospital of UPMC - Reproductive Infectious Disease Research Pittsburgh, Pennsylvania, United States, 15213-3108 收起 <<
NCT00926796	-		Completed	-	-
NCT02099240	Osteomyelitis	Early Phase 1	Recruiting	September 2019	United States, Kentucky ... 展开 >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu Sub-Investigator: Forest Arnold, DO Sub-Investigator: Timothy Wiemkwn, PhD Sub-Investigator: Robert Kelley, PhD Sub-Investigator: James Summersgill, PhD Sub-Investigator: Ruth Carrico, PhD Sub-Investigator: Julie Harting, PharmD Sub-Investigator: Paula Peyrani, MD Principal Investigator: David Seligson, MD Sub-Investigator: Craig Roberts, MD Principal Investigator: Julio Ramirez, MD 收起 <<

Cefixime/头孢克肟参考文献

[1]Neu HC, et al. In vitro activity of a new broad spectrum, beta-lactamase-stable oral cephalosporin, cefixime. Pediatr Infect Dis J. 1987 Oct;6(10):958-62.

[2]Unemo M, et al. High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure. Antimicrob Agents Chemother. 2012 Mar;56(3):1273-80.

[3]Matsumoto Y, et al. Antibacterial activity of cefixime against Salmonella typhi and applicability of Etest. J Infect Chemother. 1999 Sep;5(3):176-179.

[4]Connolly KL, et al. Pharmacokinetic Data Are Predictive of In Vivo Efficacy for Cefixime and Ceftriaxone against Susceptible and Resistant Neisseria gonorrhoeae Strains in the Gonorrhea Mouse Model. Antimicrob Agents Chemother. 2019 Feb 26;63(3):e01644-18.

[5]Shi Y, et al. Restoration of cefixime-induced gut microbiota changes by Lactobacillus cocktails and fructooligosaccharides in a mouse model. Microbiol Res. 2017 Jul;200:14-24.

[6]Stone JW, et al. Cefixime, in-vitro activity, pharmacokinetics and tissue penetration. J Antimicrob Chemother. 1989 Feb;23(2):221-8.

Cefixime/头孢克肟实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.21mL

0.44mL

0.22mL

11.03mL

2.21mL

1.10mL

22.05mL

4.41mL

2.21mL

Cefixime/头孢克肟技术信息

CAS号	79350-37-1
分子式	C₁₆H₁₅N₅O₇S₂
分子量	453.45
SMILES Code	O=C(O)C(N1[C@@]([H])([C@@H](C1=O)NC(/C(C2=CSC(N)=N2)=N\OCC(O)=O)=O)SC3)=C3C=C
MDL No.	MFCD00865020

别名	FK-027; FR-17027; Trihydrate, Cefixime; Suprax; Unixime; Cefixoral; Cefixim; Cefspan; Cephoral; Cefiximum; Cefixima; CL-284635
运输	蓝冰
InChI Key	OKBVVJOGVLARMR-QSWIMTSFSA-N
Pubchem ID	5362065

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, 2-8°C

溶解方案

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00926796	Gonorrhoea	Phase 4	Completed	-	United States, Alabama ... 展开 >> University of Alabama Hospital - Infectious Diseases Birmingham, Alabama, United States, 35249-0001 United States, California Los Angeles County Department of Public Health - Sexually Transmitted Disease Program Los Angeles, California, United States, 90007-2608 San Francisco Department of Public Health - San Francisco City Clinic San Francisco, California, United States, 94103-4030 United States, Maryland Johns Hopkins Bayview Medical Center - Infectious Diseases Baltimore, Maryland, United States, 21224-2735 United States, Pennsylvania Magee Women's Hospital of UPMC - Reproductive Infectious Disease Research Pittsburgh, Pennsylvania, United States, 15213-3108 收起 <<
NCT00926796	-		Completed	-	-
NCT02099240	Osteomyelitis	Early Phase 1	Recruiting	September 2019	United States, Kentucky ... 展开 >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu Sub-Investigator: Forest Arnold, DO Sub-Investigator: Timothy Wiemkwn, PhD Sub-Investigator: Robert Kelley, PhD Sub-Investigator: James Summersgill, PhD Sub-Investigator: Ruth Carrico, PhD Sub-Investigator: Julie Harting, PharmD Sub-Investigator: Paula Peyrani, MD Principal Investigator: David Seligson, MD Sub-Investigator: Craig Roberts, MD Principal Investigator: Julio Ramirez, MD 收起 <<
NCT01734759	Healthy	Phase 1	Completed	-	United States, Minnesota ... 展开 >> Mayo Clinic in Rochester Rochester, Minnesota, United States, 55905 收起 <<
NCT01665690	Gonorrhea Nei... 展开 >>sseria Gonorrhoeae Chlamydia Trachomatis 收起 <<	Phase 4	Completed	-	United States, Washington ... 展开 >> Washington State Department of Health Olympia, Washington, United States, 98504-7890 University of Washington Seattle, Washington, United States, 98104 收起 <<
NCT00004216	Unspecified Adult Solid Tumor,... 展开 >> Protocol Specific 收起 <<	Phase 1	Completed	-	United States, Massachusetts ... 展开 >> Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 United States, Ohio Cleveland Clinic Taussig Cancer Center Cleveland, Ohio, United States, 44195 United States, Texas Mary Crowley Medical Research Center Dallas, Texas, United States, 75246 收起 <<
NCT01720654	Gonorrhea Chl... 展开 >>amydia 收起 <<	Not Applicable	Completed	-	Peru ... 展开 >> Asociacion Civil Impacta Salud y Educacion Lima, Peru 收起 <<
NCT01388413	Neurogenic Bladder ... 展开 >> Urinary Tract Infection 收起 <<	Phase 4	Completed	-	France ... 展开 >> University Hospital, Raymond Poincaré / APHP Garches, France, 92380 University Hospital, St Jacques / NANTES Nantes, France, 44000 University Hospital, Pontchaillou / RENNES Rennes, France, 35000 University Hospital, Bretonneau / TOURS Tours, France, 37000 收起 <<
NCT02021006	Vesicoureteral Reflux ... 展开 >> Renal Hypodysplasia, Nonsyndromic, 1 Chronic Kidney Disease 收起 <<	Phase 3	Recruiting	December 2021	Italy ... 展开 >> Pediatric Nephrology Dialysis and Transplant Unit IRCCS Ca'Granda Recruiting Milan, Italy, 20122 Contact: Giovanni Montini, Professor +390255032336 giovanni.montini@unimi.it Principal Investigator: Giovanni Montini, Professor 收起 <<
NCT00644696	Neuroblastoma	Phase 1	Completed	-	United States, Michigan ... 展开 >> The University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 收起 <<
NCT02224040	Typhoid Fever	Phase 4	Unknown	August 2015	Nepal ... 展开 >> Dhulikhel hospital Recruiting Dhulikhel, Nepal, 11008 Contact: Sudeep Shrestha, M.D itsactionpotential@gmail.com 收起 <<
NCT03084601	Necrotic Pulp ... 展开 >> Postoperative Pain 收起 <<	Phase 4	Completed	-	Egypt ... 展开 >> Pedodontic Department Cairo University Cairo Governorate, Cairo, Egypt, 002 收起 <<
NCT00186979	Solid Tumors	Phase 1	Completed	-	United States, Tennessee ... 展开 >> St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 收起 <<
NCT02035137	Neuroblastoma	Phase 2	Recruiting	December 2019	United States, California ... 展开 >> Childrens Hospital Los Angeles Recruiting Los Angeles, California, United States, 90027-0700 Contact: Araz Marachelian, MD 323-361-5687 amarachelian@chla.usc.edu Lucile Salter Packer Children's Hospital Recruiting Palo Alto, California, United States, 94304 Contact: Sheri Spunt, MD UCSF Helen Diller Family Comprehensive Cancer Center Recruiting San Francisco, California, United States, 94115 Contact: Katherine Matthay, MD 415-476-3831 matthayK@peds.ucsf.edu United States, Colorado Children Hospital of Colorado Recruiting Aurora, Colorado, United States, 80045 Contact: Margaret Macy, MD 720-777-8856 Margaret.macy@childrenscolorado.org United States, Georgia AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus Recruiting Atlanta, Georgia, United States, 30322 Contact: Kelly Goldsmith, MD 404-785-0853 kgoldsm@emory.edu United States, Illinois University of Chicago, Comer Children's Hospital Recruiting Chicago, Illinois, United States, 60637 Contact: Ami Desai, MD 773-843-3943 adesai12@peds.bsd.uchicago.edu United States, Massachusetts Children's Hospital Boston Recruiting Boston, Massachusetts, United States, 02115 Contact: Suzanne Shusterman, MD 617-632-4901 United States, Michigan C.S Mott Children's Hospital Recruiting Ann Arbor, Michigan, United States, 48109 Contact: Gregory Yanik, MD 734-936-8785 gyanik@umich.edu United States, North Carolina University of North Carolina Not yet recruiting Chapel Hill, North Carolina, United States, 27599 Contact: Patrick Thompson, MD patom@email.unc.edu United States, Ohio Cincinnati Children's Hospital Medical Center Recruiting Cincinnati, Ohio, United States, 45229-3039 Contact: Brian Weiss, MD 513-636-9863 brian.weiss@chmcc.org United States, Pennsylvania Children's Hospital of Philadelphia Recruiting Philadelphia, Pennsylvania, United States, 19104-4318 Contact: Yael Mosse, MD 215-590-0965 mosse@chop.edu United States, Texas Cook Children's Healthcare System Recruiting Fort Worth, Texas, United States, 76104 Contact: Meaghan Granger, MD 682-885-4007 United States, Washington Seattle Children's Hospital Recruiting Seattle, Washington, United States, 98105 Contact: Navin Pinto, MD 206-987-5783 navin.pinto@seattlechildrens.org Canada, Ontario Hospital for Sick Children Recruiting Toronto, Ontario, Canada, M5G1X8 Contact: Meredith Irwin, MD 收起 <<
NCT03716804	Uncomplicated Urinary Tract In... 展开 >>fection Antibiotic Resistant Infection 收起 <<	Phase 4	Recruiting	January 25, 2019	Bangladesh ... 展开 >> Combined Military Hosptal, Dhaka Recruiting Dhaka, Bangladesh Contact: Abdul Quddus Bhuiyan, MBBS, FCPS 1673615641 ext +880 收起 <<
NCT01595529	Urinary Tract Infection	Phase 2	Recruiting	December 31, 2019	United States, Pennsylvania ... 展开 >> Children's Hospital of Pittsburgh of UPMC - General Academic Pediatric Recruiting Pittsburgh, Pennsylvania, United States, 15213-3205 收起 <<
NCT02830230	Cervical Inflammation and Huma... 展开 >>n Papilloma Virus Performance 收起 <<	Not Applicable	Unknown	July 2018	India ... 展开 >> Tata Memorial Hospital Not yet recruiting Mumbai, Maharashtra, India, 400012 Contact: Sharmila A Pimple, MD 91-2224154379 drsharmilapatil@yahoo.com Contact: Kavita V Anand, DGO 9892191968 drkavitaanand@gmail.com 收起 <<
NCT01390623	Acute Uncomplicated Pyelonephr... 展开 >>itis 收起 <<	Phase 4	Completed	-	France ... 展开 >> CHU de Clermont-Ferrand Clermont-Ferrand, France, 63003 收起 <<
NCT00786669	Solid Tumor	Phase 1	Completed	-	United States, Ohio ... 展开 >> Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229 收起 <<
NCT00136656	Pyelonephritis	Phase 4	Completed	-	France ... 展开 >> Hopital de Bicetre Bicetre, France, 94275 Hopital Pellegrin Bordeaux, France, 33000 Hôpital Ambroise Pare Boulogne, France, 92100 Hôpital Antoine Beclere Clamart, France, 92141 Chu de Limoges Limoges, France, 87042 La Timone Marseille, France, 13385 CHU NICE Nice, France, 06000 Saint Vincent de Paul Paris, France, 75014 Necker Enfants Malades Paris, France, 75015 Robert Debre Paris, France, 75019 Hôpital Armand Trousseau Paris, France, 75571 Hopital Andre Mignot Versailles, France, 78150 收起 <<
NCT02596503	Relapsed Solid Tumors ... 展开 >> Refractory Solid Tumors 收起 <<	Phase 1	Recruiting	September 2020	United States, Colorado ... 展开 >> Children's Hospital Colorado Recruiting Aurora, Colorado, United States, 80045 Contact: Carrye Cost, MD 720-777-6775 Carrye.Cost@childrenscolorado.org Contact: Debra Schissel, RN 720-777-2879 Debra.Schissel@childrenscolorado.org Principal Investigator: Carrye Cost, MD Sub-Investigator: Margaret Macy, MD Sub-Investigator: Lia Gore, MD United States, Kentucky University of Kentucky Recruiting Lexington, Kentucky, United States, 40536 Contact: Tom Badgett, MD, PhD 859-218-0332 tom.badgett@uky.edu Contact: Tammy Taylor, RN 859-323-6975 tammy.taylor@uky.edu Sub-Investigator: Lars Wagner, MD Sub-Investigator: Markos Leggas, PhD Principal Investigator: Tom Badgett, MD PhD United States, Texas University of Texas, Southwestern Medical Center Recruiting Dallas, Texas, United States 收起 <<
NCT00093353	Diarrhea Drug... 展开 >>/Agent Toxicity by Tissue/Organ Neuroblastoma 收起 <<	Phase 1	Completed	-	United States, California ... 展开 >> Children's Hospital Los Angeles Los Angeles, California, United States, 90027-0700 Lucile Packard Children's Hospital at Stanford University Medical Center Palo Alto, California, United States, 94304 UCSF Comprehensive Cancer Center San Francisco, California, United States, 94143 United States, Georgia AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus Atlanta, Georgia, United States, 30322 United States, Illinois Children's Memorial Hospital - Chicago Chicago, Illinois, United States, 60614 United States, Indiana Indiana University Cancer Center Indianapolis, Indiana, United States, 46202-5289 United States, Massachusetts Children's Hospital Boston Boston, Massachusetts, United States, 02115 Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Michigan University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109-0718 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229-3039 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 United States, Texas Texas Children's Cancer Center and Hematology Service at Texas Children's Hospital Houston, Texas, United States, 77030-2399 United States, Washington Children's Hospital and Regional Medical Center - Seattle Seattle, Washington, United States, 98105 收起 <<
NCT01072136	Vaginitis Bacterial ... 展开 >> Cervicitis 收起 <<	Phase 3	Terminated	-	United States, Alabama ... 展开 >> University of Alabama Hospital - Infectious Diseases Birmingham, Alabama, United States, 35249-0001 United States, California Harbor UCLA Medical Center - OBGYN - General Gynecology and Women's Health Torrance, California, United States, 90502-2006 United States, Louisiana Louisiana Stte University - Health Sciences Center - Medicine New Orleans, Louisiana, United States, 70112-1349 United States, Mississippi University of Mississippi - Infectious Diseases Jackson, Mississippi, United States, 39216-4505 收起 <<
NCT01072136	-		Terminated	-	-
NCT03408392	Infections, Bacterial	Phase 1	Completed	-	South Africa ... 展开 >> GSK Investigational Site Bloemfontein, Free State, South Africa, 9300 收起 <<
NCT01949363	Gonorrhoea	Phase 1	Completed	-	United States, Maryland ... 展开 >> Johns Hopkins Bayview Medical Center - Infectious Diseases Baltimore, Maryland, United States, 21224-2735 收起 <<
NCT02708992	Gonorrhoea	Phase 1	Completed	-	United States, North Carolina ... 展开 >> Duke University School of Medicine - Duke Clinical Research Institute - Duke Clinical Research Unit Durham, North Carolina, United States, 27710-4000 收起 <<
NCT03660488	Syphilis Earl... 展开 >>y Syphilis 收起 <<	Phase 2	Recruiting	October 2020	United States, California ... 展开 >> AHF Westside Recruiting Beverly Hills, California, United States, 90211 Contact: Carl Millner, MD carl.Millner@aidshealth.org AHF Downtown Healthcare Center Recruiting Los Angeles, California, United States, 90015 Contact: David Tellalian, MD david.tellalian@aidshealth.org AHF Carl Bean Recruiting Los Angeles, California, United States, 90018 Contact: David Tellalian, MD AHF Hollywood Healthcare Center Recruiting Los Angeles, California, United States, 90027 Contact: Pam Burian, PA 323-662-0492 Pamela.Burian@aidshealth.org AHF Wellness on Western Center Recruiting Los Angeles, California, United States, 90027 Contact: Cliff Okada, MD cliff.Okada@aidshealth.org AHF Oakland Wellness Center Recruiting Oakland, California, United States, 94606 Contact: Christopher Mejia, MPH 510-628-0949 Christopher.mejia@aidshealth.org AHF Healthcare Center Oakland Recruiting Oakland, California, United States, 94609 Contact: Seth Glassman, MD seth.glassman@aidshealth.org AHF San Francisco Recruiting San Francisco, California, United States, 94114 Contact: Seth Glassman, MD seth.glassman@aidshealth.org AHF Valley Recruiting Sherman Oaks, California, United States, 91403 Contact: James Carroll, MD james.carroll@aidshealth.org United States, Nevada AHF Las Vegas Healthcare Center Recruiting Las Vegas, Nevada, United States, 89109 Contact: Warren Magnus, MD warren.magnus@aidshealth.org 收起 <<
NCT03752112	Syphilis Female	Phase 1 Phase 2	Not yet recruiting	February 1, 2021	Brazil ... 展开 >> Fortaleza University Not yet recruiting Fortaleza, Ceara, Brazil Contact: Alix Araujo, PhD alix.araujo@hotmail.com Contact: Ivo Castell Branco Coelho, MD ivo@ufc.br Principal Investigator: Alix Araujo, PhD Principal Investigator: Mariangela Silveira, MD Principal Investigator: Angelica Miranda, MD 收起 <<
NCT03329547	Infections, Bacterial	Phase 1	Withdrawn(Change in commercial... 展开 >> strategy) 收起 <<	February 2, 2018	-

Cefixime/头孢克肟 {[allProObj[0].p_purity_real_show]}

Cefixime/头孢克肟纯度/质量文件产品仅供科研

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摩尔计算器

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Cefixime/头孢克肟纯度/质量文件产品仅供科研

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Cefixime/头孢克肟生物活性

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Cefixime/头孢克肟临床研究

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