Carbenoxolone disodium, derived from Glycyrrhizic acid, acts as an inhibitor of both human 11β-HSD and bacterial 3α, 20β-HSD enzymes[1]. Carbenoxolone disodium also serves as an uncoupling agent for gap junctions and effectively inhibits the replication of Vaccinia virus[2].
Carbenoxolone disodium 动物研究
Animal study
In animal models, Carbenoxolone administered via intraperitoneal injection (100, 200, and 300 mg/kg; at 30, 60, and 60 minutes before Diazepam) does not exhibit muscle relaxant activity compared to normal saline, and it even surpasses diazepam in effectiveness in the traction test[3]. Additionally, when given before Pentylenetetrazole (PTZ), Carbenoxolone significantly prolongs sleep time and reduces latency in a dose-dependent manner in a PTZ seizure model, with an effective dose (ED50) of 83.3 mg/kg (95% confidence limit: 556.29)[3].
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