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Carbenoxolone disodium {[allProObj[0].p_purity_real_show]}

货号:A862176

Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.

Carbenoxolone disodium 化学结构 CAS号:7421-40-1
Carbenoxolone disodium 化学结构
CAS号:7421-40-1
Carbenoxolone disodium 3D分子结构
CAS号:7421-40-1
Carbenoxolone disodium 化学结构 CAS号:7421-40-1
Carbenoxolone disodium 3D分子结构 CAS号:7421-40-1
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Carbenoxolone disodium 纯度/质量文件 产品仅供科研

货号:A862176 标准纯度: {[allProObj[0].p_purity_real_show]}
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Carbenoxolone disodium 生物活性

描述 Carbenoxolone disodium, derived from Glycyrrhizic acid, acts as an inhibitor of both human 11β-HSD and bacterial 3α, 20β-HSD enzymes[1]. Carbenoxolone disodium also serves as an uncoupling agent for gap junctions and effectively inhibits the replication of Vaccinia virus[2].

Carbenoxolone disodium 动物研究

Animal study In animal models, Carbenoxolone administered via intraperitoneal injection (100, 200, and 300 mg/kg; at 30, 60, and 60 minutes before Diazepam) does not exhibit muscle relaxant activity compared to normal saline, and it even surpasses diazepam in effectiveness in the traction test[3]. Additionally, when given before Pentylenetetrazole (PTZ), Carbenoxolone significantly prolongs sleep time and reduces latency in a dose-dependent manner in a PTZ seizure model, with an effective dose (ED50) of 83.3 mg/kg (95% confidence limit: 556.29)[3].

Carbenoxolone disodium 参考文献

[1]W L Duax, et al. Steroid Dehydrogenase Structures, Mechanism of Action, and Disease. Vitam Horm. 2000;58:121-48.

[2]Hossein Hosseinzadeh, et al. Anticonvulsant, Sedative and Muscle Relaxant Effects of Carbenoxolone in Mice. BMC Pharmacol. 2003 Apr 29;3:3.

[3]Ismar R Haga, et al. Carbenoxolone-mediated Cytotoxicity Inhibits Vaccinia Virus Replication in a Human Keratinocyte Cell Line. Sci Rep. 2018 Nov 16;8(1):16956.

Carbenoxolone disodium 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.63mL

0.33mL

0.16mL

8.13mL

1.63mL

0.81mL

16.27mL

3.25mL

1.63mL

Carbenoxolone disodium 技术信息

CAS号7421-40-1
分子式C34H48Na2O7
分子量 614.72
SMILES Code C[C@@](CC[C@]1(C2(C)C)[H])([C@]3([C@@]1(C)CC[C@@H]2OC(CCC([O-])=O)=O)[H])[C@@](CC[C@@]4([C@]5(C[C@](C)(CC4)C([O-])=O)[H])C)(C)C5=CC3=O.[Na+].[Na+]
MDL No. MFCD03840711
别名
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, 2-8°C

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