CX516 | BDP 12;Ampalex;Benzoyl-Piperidine-12;SPD 420;Ampakine CX 516 | 安帕莱克斯 | AMPAR

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CX516/安帕来斯 {[allProObj[0].p_purity_real_show]}

货号：A240364 同义名： 安帕莱克斯 / BDP 12; Ampalex.

Ampalex is a positive allosteric modulator of AMPAR and is researched as a treatment for Alzheimer's disease.

CX516/安帕来斯化学结构
CAS号：154235-83-3

CX516/安帕来斯 3D分子结构
CAS号：154235-83-3

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CX516/安帕来斯纯度/质量文件产品仅供科研

货号：A240364 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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CX516/安帕来斯生物活性

描述

Ampalex (Ampakine, CX516) is an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI) ^[3]. This AMPAkine can be administered directly into the prefrontal cortex to provide analgesia, and that prefrontal AMPAkine infusion, similar to systemic administration, can provide added pain relief to complement morphine analgesia^[4]. BDNF(brain-derived neurotrophic factor) expression is influenced by lower doses of, and shorter treatments with, the ampakine than is AMPAR expression^[5].

CX516/安帕来斯临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00858689	Fragile X Syndrome	Not Applicable	Completed	-	Canada, Ontario ... 展开 >> Surrey Place Centre Toronto, Ontario, Canada, M5S 2C2 收起 <<
NCT00858689	-		Completed	-	-
NCT00235352	Schizophrenia	Phase 2 Phase 3	Completed	-	United States, Massachusetts ... 展开 >> Freedom Trail Clinic Boston, Massachusetts, United States, 02114 收起 <<

CX516/安帕来斯参考文献

[1]Goff DC, Lamberti JS, et al. A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia. Neuropsychopharmacology. 2008 Feb;33(3):465-72.

[2]Johnson SA, Simmon VF. Randomized, double-blind, placebo-controlled international clinical trial of the Ampakine CX516 in elderly participants with mild cognitive impairment: a progress report. J Mol Neurosci. 2002 Aug-Oct;19(1-2):197-200.

[3]Goff DC, Lamberti JS, Leon AC, Green MF, Miller AL, Patel J, Manschreck T, Freudenreich O, Johnson SA. A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia. Neuropsychopharmacology. 2008 Feb;33(3):465-72. doi: 10.1038/sj.npp.1301444. Epub 2007 May 9. PMID: 17487227; PMCID: PMC3098468.

[4]Sun Y, Liu K, Martinez E, Dale J, Huang D, Wang J. AMPAkines and morphine provide complementary analgesia. Behav Brain Res. 2017 Sep 15;334:1-5. doi: 10.1016/j.bbr.2017.07.020. Epub 2017 Jul 19. PMID: 28734765; PMCID: PMC5621600.

[5]Lauterborn JC, Pineda E, Chen LY, Ramirez EA, Lynch G, Gall CM. Ampakines cause sustained increases in brain-derived neurotrophic factor signaling at excitatory synapses without changes in AMPA receptor subunit expression. Neuroscience. 2009 Mar 3;159(1):283-95. doi: 10.1016/j.neuroscience.2008.12.018. Epub 2008 Dec 24. PMID: 19141314; PMCID: PMC2746455.

CX516/安帕来斯实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

4.14mL

0.83mL

0.41mL

20.72mL

4.14mL

2.07mL

41.44mL

8.29mL

4.14mL

CX516/安帕来斯技术信息

CAS号	154235-83-3
分子式	C₁₄H₁₅N₃O
分子量	241.29
SMILES Code	O=C(N1CCCCC1)C2=CC=C3N=CC=NC3=C2
MDL No.	MFCD00943201

别名	安帕莱克斯 ;BDP 12; Ampalex.; Benzoyl-Piperidine-12; SPD 420; Ampakine CX 516
运输	蓝冰
InChI Key	ANDGGVOPIJEHOF-UHFFFAOYSA-N
Pubchem ID	148184

存储条件

In solvent -20°C:3-6个月-80°C:12个月

溶解方案

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00858689	Fragile X Syndrome	Not Applicable	Completed	-	Canada, Ontario ... 展开 >> Surrey Place Centre Toronto, Ontario, Canada, M5S 2C2 收起 <<
NCT00858689	-		Completed	-	-
NCT00235352	Schizophrenia	Phase 2 Phase 3	Completed	-	United States, Massachusetts ... 展开 >> Freedom Trail Clinic Boston, Massachusetts, United States, 02114 收起 <<
NCT00001662	Alzheimer's Disease ... 展开 >> Dementia 收起 <<	Phase 2	Completed	-	United States, Maryland ... 展开 >> National Institute of Neurological Disorders and Stroke (NINDS) Bethesda, Maryland, United States, 20892 收起 <<
NCT00040443	Mild Cognitive Impairment	Phase 2	Completed	-	United States, Arizona ... 展开 >> Pivotal Research Centers Peoria, Arizona, United States, 85381 United States, California University of California Irvine Irvine, California, United States, 92697 University of California at Los Angeles Los Angeles, California, United States, 90095 University of California, San Diego San Diego, California, United States, 92093 United States, Connecticut Yale University School of Medicine New Haven, Connecticut, United States, 06510 United States, Florida Sun Coast Gerontology Center, University of South Florida Tampa, Florida, United States, 33617 United States, Iowa Mercy Mayo Clinic Des Moines, Iowa, United States, 50314 United States, Pennsylvania University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 收起 <<
NCT00040443	-		Completed	-	-
NCT00054730	Fragile X Syndrome ... 展开 >> Autism 收起 <<	Phase 2	Completed	-	United States, California ... 展开 >> UC Davis-MIND Institute Sacramento, California, United States, 95817 United States, Illinois RUSH-Presbyterian-St. Luke's Medical Center Chicago, Illinois, United States, 60612 收起 <<

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最近浏览的产品

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摩尔计算器

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总药量计算器

工作液计算器

细胞研究

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