Selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 μM). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and TLR7 or a panel of 10 representative kinases. Inhibits the release of proinflammatory cytokines TNF-α and IL-1β.
HazMat Fee +
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
The protein complex of toll-like receptor 1 and 2 (TLR1/2) is a key regulator of cytokine responses to human cytomegalovirus, lymphocytic choriomeningitis virus, and herpes simplex virus 1. CU-CPT22 is a small-molecule inhibitor of the TLR1/2 complex with an IC50 value of 0.58 ± 0.09µM. CU-CPT22 competed with Pam3CSK4 for binding to TLR1/2 with a Ki value of 0.41±0.07µM. CU-CPT22 at a concentration of 0.5µM inhibited TLR1/2 signaling without affecting other TLRs. CU-CPT22 at 8µM inhibited ~60% of TNF-α and 95% of IL-1β in RAW 264.7 cells[2]. In Otsuka-Long-Evans-Tokushima fatty rats, treatment with Cu-CPT22 significantly reduced the kidney injury molecule-1-positive area in the kidney 12 hours after myocardial infarction. Cu-CPT22-treated rats also showed significantly decreased mRNA expressions of TLR2, TLR4, MyD88, IL-1β, and CCL2 compared with vehicle-treated controls[3].
搜索
HazMat Fee +
