CP-376395 is a CRF1-selective antagonist. CRF1 receptor signaling regulates food and fluid intake in the drinking-in-the-dark model of binge alcohol consumption
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描述 | CP 376395 is a potent, selective, and centrally penetrable antagonist of the Corticotropin-releasing factor 1 (CRF1) receptor[1][2]. |
Animal study | CP 376395 (10-20 mg/kg, i.p., Male B6 mice) reduces H2O and food consumption, enhances sucrose intake, decreases ethanol intake, but does not affect ethanol preference[2]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.06mL 0.61mL 0.31mL |
15.31mL 3.06mL 1.53mL |
30.63mL 6.13mL 3.06mL |
CAS号 | 175140-00-8 |
分子式 | C21H30N2O |
分子量 | 326.48 |
SMILES Code | CCC(NC1=C(C)C(OC2=C(C)C=C(C)C=C2C)=NC(C)=C1)CC |
MDL No. | MFCD14584860 |
别名 | CP 316,311 |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Sealed in dry, 2-8°C |