Bromopride | 溴灭吐灵 | Emepride | Dopamine Receptor Antagonist

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Bromopride/溴必利 {[allProObj[0].p_purity_real_show]}

货号：A764267 同义名： 溴灭吐灵 / Emepride; Viadil

Bromopride is a dopamine antagonist with prokinetic properties, widely used as an antiemetic.

Bromopride/溴必利化学结构
CAS号：4093-35-0

Bromopride/溴必利 3D分子结构
CAS号：4093-35-0

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Bromopride/溴必利纯度/质量文件产品仅供科研

货号：A764267 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: 更多 >

多巴胺受体亚型比较

产品名称	D1 receptor ↓ ↑	D2 receptor ↓ ↑	D3 receptor ↓ ↑	D4 receptor ↓ ↑	D5 receptor ↓ ↑	DAT ↓ ↑	Dopamine receptor ↓ ↑	其他靶点	纯度
Penfluridol	+ Dopamine receptor, Ki: 1.6 μM								98%
Ansofaxine HCl	++ Dopamine receptor, IC50: 491 nM								99%
Tetrahydroberberine		+ D2 receptor, pKi: 6.08							98+%
Prochlorperazine Maleate		✔							98% (HPLC)
Olanzapine		✔							99+%
Trifluoperazine		++++ Dopamine D2 receptor, IC50: 1.1 nM							98%
Ropinirole HCl		++ D2 receptor, Ki: 29 nM							99%
Lurasidone		++++ D2 receptor, Ki: 1 nM							98%
Levosulpiride		✔							99+%
Pridopidine		✔							95%
Metoclopramide		✔					✔		99+%
Molindone HCl		✔							99%
Sulpiride		✔							99+%
Perospirone		++++ D2 receptor, Ki: 1.4 nM							99%
Perospirone HCl		++++ D2 receptor, Ki: 1.4 nM							99%
Phenothiazine		✔							98%
Pimozide	+ Dopamine D1 receptor, Ki: 6600 nM	+++ Dopamine D2 receptor, Ki: 3.0 nM	++++ Dopamine D3 receptor, Ki: 0.83 nM						98%
Rotundine	++ D1 receptor, IC50: 166 nM	+ D2 receptor, IC50: 1.47 μM	+ D3 receptor, IC50: 3.25 μM						98%
Domperidone		✔							99+%
ONC206		✔							99%
Pimethixene maleate	++ Dopamine D1 Receptor, pKi: 6.37	+++ Dopamine D2 Receptor, pKi: 8.19		++ Dopamine D4.4 Receptor, pKi: 7.54					97%
Loxapine succinate	++ D2 receptor (Human), Ki: 62 nM D1 receptor (human), Ki: 26 nM	++ D2 receptor (bovine), Ki: 26 nM D2 receptor (human), Ki: 24 nM		+++ D4 receptor (human), Ki: 7.5 nM					98%
Chlorprothixene	+++ D1 receptor, Ki: 18 nM	+++ D2 receptor, Ki: 2.96 nM	+++ D3 receptor, Ki: 4.56 nM		+++ D5 receptor, Ki: 9 nM				99%
SCH-23390 HCl	++++ D1 dopamine receptor, Ki: 0.2 nM				++++ D5 dopamine receptor, Ki: 0.3 nM				98%
MPP+ iodide						✔			97%
σ1 Receptor antagonist-1						+ DAT, pKi: 5.8			97%
Benztropine mesylate						++ DAT, IC50: 118 nM			98%
Azaperone							✔		98%
Ziprasidone HCl							✔		98+%
Paliperidone							✔		98%
Alizapride HCl							✔		99+%
Amisulpride							✔		98%
Quetiapine hemifumarate							✔	Adrenergic Receptor	98%
Clozapine N-oxide							✔		99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Bromopride/溴必利生物活性

描述	Bromopride is a dopamine antagonist with prokinetic properties, widely used as an antiemetic.

Bromopride/溴必利临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02604576	Dyspepsia	Phase 3	Recruiting	August 2018	Brazil ... 展开 >> Centro de Medicina Reprodutiva Carlos Isaia Filho Ltda Recruiting Porto Alegre, Rio Grande Do Sul, Brazil Contact: Carlos Isaia Filho, MD Hospital de Clínicas de Porto Alegre Recruiting Porto Alegre, Rio Grande Do Sul, Brazil Contact: Carlos Fernando Francesconi, MD Hospital Ernesto Dornelles Recruiting Porto Alegre, RS, Brazil, 90160-092 Contact: Guilherme B. Sander, MD UNIFAG Recruiting Bragança Paulista, SP, Brazil, 129169000 Contact: José Pedrazzoli, MD Loema Recruiting Campinas, SP, Brazil, 13010001 Contact: Fabio R Santos, MD contato@loemaipc.com.br Principal Investigator: Fabio R Santos, MD Instituto de Pesquisa Clinica de Campinas Recruiting Campinas, SP, Brazil, 13060-080 Contact: José Francisco K. Saraiva, MD Centro de Estudos Clínicos do Interior Paulista Recruiting Jau, SP, Brazil, 17201-130 Contact: Paula Tokunaga, MD Faculdade de Medicina do ABC Recruiting Santo André, SP, Brazil, 09060-650 Contact: Wilson Catapani, MD AFIP Recruiting São Paulo, Sâo Paulo, Brazil, 04020-060 Contact: Edson Ide, MD Allergisa Recruiting Campinas, São Paulo, Brazil Contact: Mauro A Crippa, MD 收起 <<

Bromopride/溴必利参考文献

[1]Silva SM, Jerônimo MS, et al. Effects of bromopride on expression of metalloproteinases and interleukins in left colonic anastomoses: an experimental study. Braz J Med Biol Res. 2014 Oct;47(10):911-6.

[2]Marques e Silva S, Ferreira VM, et al. Effects of bromopride on the healing of left colon anastomoses of rats. Rev Col Bras Cir. 2011 Nov-Dec;38(6):429-34. English, Portuguese.

Bromopride/溴必利实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.90mL

0.58mL

0.29mL

14.52mL

2.90mL

1.45mL

29.05mL

5.81mL

2.90mL

Bromopride/溴必利技术信息

CAS号	4093-35-0
分子式	C₁₄H₂₂BrN₃O₂
分子量	344.25
SMILES Code	O=C(NCCN(CC)CC)C1=CC(Br)=C(N)C=C1OC
MDL No.	N/A

别名	溴灭吐灵 ;Emepride; Viadil; Emoril
运输	蓝冰

存储条件	In solvent -20°C:3-6个月-80°C:12个月 Pure form Keep in dark place, inert atmosphere, 2-8°C

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02604576

Dyspepsia

Phase 3

Recruiting

August 2018

Brazil ... 展开 >> Centro de Medicina Reprodutiva Carlos Isaia Filho Ltda Recruiting Porto Alegre, Rio Grande Do Sul, Brazil Contact: Carlos Isaia Filho, MD Hospital de Clínicas de Porto Alegre Recruiting Porto Alegre, Rio Grande Do Sul, Brazil Contact: Carlos Fernando Francesconi, MD Hospital Ernesto Dornelles Recruiting Porto Alegre, RS, Brazil, 90160-092 Contact: Guilherme B. Sander, MD UNIFAG Recruiting Bragança Paulista, SP, Brazil, 129169000 Contact: José Pedrazzoli, MD Loema Recruiting Campinas, SP, Brazil, 13010001 Contact: Fabio R Santos, MD contato@loemaipc.com.br Principal Investigator: Fabio R Santos, MD Instituto de Pesquisa Clinica de Campinas Recruiting Campinas, SP, Brazil, 13060-080 Contact: José Francisco K. Saraiva, MD Centro de Estudos Clínicos do Interior Paulista Recruiting Jau, SP, Brazil, 17201-130 Contact: Paula Tokunaga, MD Faculdade de Medicina do ABC Recruiting Santo André, SP, Brazil, 09060-650 Contact: Wilson Catapani, MD AFIP Recruiting São Paulo, Sâo Paulo, Brazil, 04020-060 Contact: Edson Ide, MD Allergisa Recruiting Campinas, São Paulo, Brazil Contact: Mauro A Crippa, MD 收起 <<

Bromopride/溴必利 {[allProObj[0].p_purity_real_show]}

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