Bromocriptine mesylate is a potent dopamine D2/D3 receptoragonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.
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Bromocriptine mesylate (BRC), a dopamine D2 receptor agonist has been shown to confer neuroprotection, sustained motor function and slowed disease progression in mouse models of amyotrophic lateral sclerosis (ALS) Here we report a first in human trial in ALS[3]. Bromocriptine stimulates [35S]-GTPγS binding at D2 dopamine receptor expressed in CHO cells with pEC50 of 8.15±0.05[4]. Bromocriptine is found to inhibit the activity of at least one human cytochrome P450 enzyme. Bromocriptine is a potent inhibitor of CYP3A4 with a calculated IC50 value for the interaction of 1.69 μM[5]. Bromocriptine mesylate (2 mg/kg, i.p.) is administered for 7 days in groups of mice in forced swimming test (FST) and tail suspension test (TST). Bromocriptine group shows significant anti-immobility action as compared to control. When Bromocriptine administered 30 min after the last dose of 7 days MPE treatment and subjected to FST, this dopaminergic agonist produces significant and dose dependent potentiation of anti-immobility action of MPE (200 mg/kg, p.o.) as compared to MPE treatment alone. Bromocriptine treatment group shows a significant reduction of immobility time as compared to control. Bromocriptine administration after 7 days pretreatment with MPE (100 and 200 mg/kg, p.o.) shows significant and dose dependent potentiation of anti-immobility action of MPE as compared to MPE treatment alone[6].
United States, New Jersey
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International Brain Research Foundation
Recruiting
Edison, New Jersey, United States, 08837
Contact: Philip Defina, PhD 732-494-7600 pdefina@ibrfinc.org
Principal Investigator: Philip Defina, PhD 收起 <<
Italy
... 展开 >> Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples
via S. Pansini 5 Naples, Italy, 80131 收起 <<
United States, New Jersey
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Kessler Institute of Rehabilitation
Recruiting
Chester, New Jersey, United States, 07930
Contact: Jenny Masmela, BA 973-324-3564 jmasmela@kesslerfoundation.org
Contact: Anna M Barrett, MD 973 324-3569
Kessler Institute of Rehabilitation
Recruiting
Saddle Brook, New Jersey, United States, 07663
Contact: Jenny Masmela, BA 973-324-3564 jmasmela@kesslerfoundation.org
Contact: Anna M Barrett, MD 973 324-3569
Kessler Foundation Research Center
Recruiting
West Orange, New Jersey, United States, 07052
Contact: Jenny Masmela, BA 973-324-3564 jmasmela@kesslerfoundation.org
Contact: Anna Barrett, MD 973 324-3569 收起 <<
Germany
... 展开 >> University Hospital Cologne
Recruiting
Cologne, Germany
Contact: Michael Faust, MD
University Hospital Luebeck
Recruiting
Luebeck, Germany
Contact: Sebastian Schmid, MD
University of Tuebingen, Department of Internal Medicine IV
Recruiting
Tübingen, Germany, 72076
Contact: Martin Heni, MD +49 7071 29 82714 martin.heni@med.uni-tuebingen.de
Contact: Andreas Fritsche, MD +49 7071 29 82714 andreas.fritsche@med.uni-tuebingen.de
Principal Investigator: Stephanie Kullmann, PhD 收起 <<
China
... 展开 >> First Hospital of Beijing University
Beijing, China, 100034
Beijing Tian Tan Hospital
Beijing, China, 100050
Beijing Hospital
Beijing, China, 100730
Peking Union Medical College Hospital
Beijing, China, 100730
General Hospital of PLA
Beijing, China, 100853
Shanghai Rui Jin Hospital
Shanghai, China, 200025
Hua Shan Hospital, Fu Dan University
Shanghai, China, 200040 收起 <<
Germany
... 展开 >> University of Bonn, Department of Psychiatry
Not yet recruiting
Bonn, Northrhine-Westfalia, Germany, 53105
Contact: Kai-Uwe Kuehn, MD 0049-(0)2228-287-5681 kai-uwe.kuehn@ukb.uni-bonn.de 收起 <<
United States, California
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University of California, Berkeley
Berkeley, California, United States, 94704
University of California, San Francisco
San Francisco, California, United States, 94158 收起 <<
United States, Colorado
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University of Colorado-Denver, Anshutz Medical Campus
Recruiting
Aurora, Colorado, United States, 80045
Contact: Ellen Lyon, MS 720-848-6690 ellen.lyon@ucdenver.edu
Contact: Amy Baumgartner, MS 720-777-5774 amy.baumgartner@childrenscolorado.org 收起 <<
United States, Texas
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UT Southwestern Medical Center
Dallas, Texas, United States, 75390
UT Southwestern
Dallas, Texas, United States, 75390 收起 <<
Korea, Republic of
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Korea University Ansan Hospital
Ansan, Korea, Republic of
Inje University Busan Paik Hospital
Busan, Korea, Republic of
Youngnam University Hospital
Daegu, Korea, Republic of
Kangwon Nat'l University Hospital
Kangwon, Korea, Republic of
Inje university Sanggye Paik Hospital
Seoul, Korea, Republic of
Korea University Anam Hospital
Seoul, Korea, Republic of
Korea University Guro Hospital
Seoul, Korea, Republic of 收起 <<
Canada, Nova Scotia
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IWK Health Centre
Not yet recruiting
Halifax, Nova Scotia, Canada, B3K 6R8
Contact: Renda Bouzayen, MD, FRCSC 902-470-6457 renda.bouzayen@iwk.nshealth.ca
Contact: Cora Fanning, BN 902-470-7158 cora.fanning@iwk.nshealth.ca
Principal Investigator: Renda Bouzayen, MD, FRCSC 收起 <<
United States, California
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Zuckerberg San Francisco General Hospital and Trauma Center
Recruiting
San Francisco, California, United States, 94110
Contact: Judy H Ch'ang, MD 415-502-1453 judy.chang@ucsf.edu
Contact: Anthony S Kim, MD, MAS 415-476-3733 anthony.kim@ucsf.edu
University of California, San Francisco Medical Center - Parnassus
Recruiting
San Francisco, California, United States, 94143
Contact: Judy H Ch'ang, MD 415-502-1453 judy.chang@ucsf.edu
Contact: Anthony S Kim, MD, MAS 415-476-3733 anthony.kim@ucsf.edu
Sub-Investigator: Hildegarde Schell-Chapele, PhD, RN 收起 <<
United States, Arizona
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Hope Research Institute, Llc
Phoenix, Arizona, United States, 85018
United States, Connecticut
Yale Center for Clinical Investigation
New Haven, Connecticut, United States, 06511
United States, Florida
Columbus Clinical Services LLC
Miami, Florida, United States, 33165
United States, Missouri
The Children's Mercy Hospital
Kansas City, Missouri, United States, 64108
United States, Pennsylvania
Children's Hosptial of Philadelphia
Philadelphia, Pennsylvania, United States, 19104 收起 <<
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