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/ Bergapten/佛手柑内酯

Bergapten/佛手柑内酯 {[allProObj[0].p_purity_real_show]}

货号：A141454 同义名： 佛手苷内酯 / 5-Methoxypsoralen; 5-MOP

5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation [psoralen plus UV (PUVA)] to manage psoriasis and vitiligo and inhibits proliferation in the human hepatocellular carcinoma cell line.

Bergapten/佛手柑内酯 化学结构 CAS号：484-20-8
Bergapten/佛手柑内酯 化学结构
CAS号：484-20-8
Bergapten/佛手柑内酯 3D分子结构
CAS号：484-20-8
Bergapten/佛手柑内酯 化学结构 CAS号：484-20-8
Bergapten/佛手柑内酯 3D分子结构 CAS号：484-20-8
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Bergapten/佛手柑内酯 纯度/质量文件 产品仅供科研

货号：A141454 标准纯度： {[allProObj[0].p_purity_real_show]}
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Bergapten/佛手柑内酯 生物活性

描述 5-Methoxypsoralen (Bergapten) is a natural anti-inflammatory and anti-tumor agent isolated from bergamot essential oil, other citrus essential oils and grapefruit juice. 5-methoxypsoralen led to time-dependent as well as dose-dependent inhibitory effects on U-87MG human glioma cells. 5-Methoxypsoralen led to a substantial decrease of cell count along with distorted cell morphology. 5-methoxypsoralen also led to dose-dependent G2/M phase cell cycle arrest. 5-Methoxypsoralen-treated cells also exhibited altered cell ultrastructure with the appearance of autophagic vacuoles and the number of these vacuoles increased with increasing drug dose[3]. 5-MOP (5-Methoxypsoralen) increased the activity of NAT (N-acetyltransferase) and also increased the further metabolism of AAF ( 2-acetylaminofluorene) at 24 h in the rat stomach. 5-MOP decreased the activity of NAT only at 72-h incubation in SC-M1 cells. The optimal concentrations of 5-MOP to induce decreased NAT activity in SC-M1 (human stomach) cells were 0.05 mM to 25 mM. In COLO 205 cells, there is decreased NAT activity at low doses of Bergapten (0.05 mM and 0.5 mM) and increased NAT activity at a high dose (50 mM)[4]. In addition, DSG (diosgenin) and 5-MOP may improve insulin resistance through an ER-mediated PI3K/Akt activation pathway[5].

Bergapten/佛手柑内酯 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00533195 Atopic Dermatitis Phase 3 Completed - Austria ... 展开 >> Medical University of Vienna; University Clinic of Dermatology; Division of Special and Environmental Dermatology Vienna, Austria, 1090 收起 <<
NCT00811005 Pustular Palmoplantar Psoriasi... 展开 >>s 收起 << Phase 3 Unknown October 2010 Austria ... 展开 >> Medical University of Vienna; University Clinic of Dermatology; Division of Special and Environmental Dermatology Vienna, Austria, 1180 收起 <<

Bergapten/佛手柑内酯 参考文献

[1]Panno ML, Giordano F, et al.Bergapten induces ER depletion in breast cancer cells through SMAD4-mediated ubiquitination. Breast Cancer Res Treat. 2012 Nov;136(2):443-55.

[2]Liu WX, Jia FL, et al. Protective effects of 5-methoxypsoralen against acetaminophen-induced hepatotoxicity in mice. World J Gastroenterol. 2012 May 14;18(18):2197-202.

[3]Guo H, He Y, Bu C, Peng Z. Antitumor and apoptotic effects of 5-methoxypsoralen in U87MG human glioma cells and its effect on cell cycle, autophagy and PI3K/Akt signaling pathway. Arch Med Sci. 2019;15(6):1530-1538

[4]Lee YM, Wu TH. Effects of 5-methoxypsoralen (5-MOP) on arylamine N-acetyltransferase activity in the stomach and colon of rats and human stomach and colon tumor cell lines. In Vivo. 2005;19(6):1061-1069

[5]Fang K, Dong H, Jiang S, et al. Diosgenin and 5-Methoxypsoralen Ameliorate Insulin Resistance through ER-α/PI3K/Akt-Signaling Pathways in HepG2 Cells. Evid Based Complement Alternat Med. 2016;2016:7493694

Bergapten/佛手柑内酯 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.63mL

0.93mL

0.46mL

23.13mL

4.63mL

2.31mL

46.26mL

9.25mL

4.63mL

Bergapten/佛手柑内酯 技术信息

CAS号484-20-8
分子式C12H8O4
分子量 216.19
SMILES Code O=C1C=CC2=C(O1)C=C(OC=C3)C3=C2OC
MDL No. MFCD00010272
别名 佛手苷内酯 ;5-Methoxypsoralen; 5-MOP; NSC 95437; Heraclin
运输蓝冰
InChI Key BGEBZHIAGXMEMV-UHFFFAOYSA-N
Pubchem ID 2355
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, room temperature

Tags: Bergapten | 5-Methoxypsoralen;5-MOP;NSC 95437;Heraclin | 佛手苷内酯 | Plant Standard | P450 | AmBeed-信号通路专用抑制剂 | Bergapten/佛手柑内酯 纯度/质量文件 | Bergapten/佛手柑内酯 生物活性 | Bergapten/佛手柑内酯 临床数据 | Bergapten/佛手柑内酯 参考文献 | Bergapten/佛手柑内酯 实验方案 | Bergapten/佛手柑内酯 技术信息

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