Berberine chloride|Natural Yellow 18 chloride; Berberine (chloride); NSC 163088; Umbellatine; BBR; NSC 646666|盐酸黄连素||for research only|Ambeed

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Berberine chloride/盐酸小檗碱 {[allProObj[0].p_purity_real_show]}

货号：A256069 同义名： 盐酸黄连素 / Natural Yellow 18 chloride; Berberine (chloride)

Berberine HCl is an isoquinoline alkaloid isolated from the herb of Coptis chinensis Franch with anti-inflammatory and anti-diabetic effects.

Berberine chloride/盐酸小檗碱化学结构
CAS号：633-65-8

Berberine chloride/盐酸小檗碱 3D分子结构
CAS号：633-65-8

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Berberine chloride/盐酸小檗碱纯度/质量文件产品仅供科研

货号：A256069 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

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Berberine chloride/盐酸小檗碱生物活性

描述

Berberine hydrochloride is a major alkaloid from Coptis chinensis and used clinically for the treatment of diarrhea, hypertension, diabetes and other diseases. Berberine hydrochloride suppressed the growth of cells in a time- and dose-dependent manner(60-200 µM ). Moreover, treatment with 60 and 90 µM berberine hydrochloride significantly increased the activity of the Bcl-2/Bax signaling pathway in A549 cells^[3]. Berberine hydrochloride (5, 10, and 20 mg/kg) significantly attenuated neutrophil infiltration and dose-dependently decreased the secretion and mRNA expressions of TNF-α, IL-1β, and IL-6 within a certain range^[4].

Berberine chloride/盐酸小檗碱细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源
A10 cells	30 μM	Function assay	24 hrs	Downregulation of Scd2 mRNA expression in rat A10 cells at 30 uM after 24 hrs by quantitative RT-PCR analysis	21401114
A10 cells	30 μM	Function assay	24 hrs	Down regulation of Prim2 mRNA expression in rat A10 cells at 30 uM after 24 hrs by quantitative RT-PCR analysis	21401114
A10 cells	30 μM	Function assay	24 hrs	Downregulation of Impk mRNA expression in rat A10 cells at 30 uM after 24 hrs by quantitative RT-PCR analysis	21401114
A549 cells		Cytotoxicity assay		Cytotoxicity against human A549 cells by SRB assay, IC50=6.27 μM	20594848

Berberine chloride/盐酸小檗碱临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02969070	Hypercholesterolemia ... 展开 >> Endothelial Dysfunction 收起 <<	Phase 3	Unknown	March 2017	Italy ... 展开 >> University of Naples "Federico II" Recruiting Naples, Italy, 80131 Contact: Giuseppe Giugliano, MD, PhD +390817462240 giuseppe.giugliano@unina.it Sub-Investigator: Raffaele Izzo, MD Sub-Investigator: Maurizio Galderisi, MD Sub-Investigator: Giuseppe Giugliano, MD, PhD 收起 <<
NCT02861261	Type 2 Diabetes	Phase 3	Active, not recruiting	August 2018	China, Shanghai ... 展开 >> Ruijin hospital,Shanghai Jiao Tong University School of Medicine Shanghai, Shanghai, China 收起 <<
NCT03378934	Coronary Artery Disease ... 展开 >> Percutaneous Coronary Intervention 收起 <<	Phase 4	Recruiting	April 2020	China, Beijing ... 展开 >> Peking Union Medical College Hospital Recruiting Beijing, Beijing, China, 100730 Contact: Zhenyu Liu, M.D. +861069155068 pumch_lzy@163.com Contact: Lihong Xu, B.N. +861069155068 xulihong1990@163.com 收起 <<

Berberine chloride/盐酸小檗碱参考文献

[1]Wang Y, Yi X, et al. Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption. Metabolism. 2014 Sep;63(9):1167-77.

[2]Yu R, Zhang ZQ, et al. Berberine-induced apoptotic and autophagic death of HepG2 cells requires AMPK activation. Cancer Cell Int. 2014 Jun 11;14:49.

[3]Li J, Liu F, Jiang S, Liu J, Chen X, Zhang S, Zhao H. Berberine hydrochloride inhibits cell proliferation and promotes apoptosis of non-small cell lung cancer via the suppression of the MMP2 and Bcl-2/Bax signaling pathways. Oncol Lett. 2018 May;15(5):7409-7414. doi: 10.3892/ol.2018.8249. Epub 2018 Mar 13. PMID: 29725453; PMCID: PMC5920480.

[4]Wang X, Feng S, Ding N, He Y, Li C, Li M, Ding X, Ding H, Li J, Wu J, Li Y. Anti-Inflammatory Effects of Berberine Hydrochloride in an LPS-Induced Murine Model of Mastitis. Evid Based Complement Alternat Med. 2018 Apr 15;2018:5164314. doi: 10.1155/2018/5164314. PMID: 29849710; PMCID: PMC5925179.

Berberine chloride/盐酸小檗碱实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.45mL

2.69mL

1.34mL

26.90mL

5.38mL

2.69mL

Berberine chloride/盐酸小檗碱技术信息

CAS号	633-65-8
分子式	C₂₀H₁₈ClNO₄
分子量	371.81
SMILES Code	COC1=CC=C2C=C3[N+](CCC4=C3C=C(OCO5)C5=C4)=CC2=C1OC.[Cl-]
MDL No.	MFCD00011939

别名	盐酸黄连素 ;Natural Yellow 18 chloride; Berberine (chloride); NSC 163088; Umbellatine; BBR; NSC 646666
运输	蓝冰
InChI Key	VKJGBAJNNALVAV-UHFFFAOYSA-M
Pubchem ID	12456

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, 2-8°C

动物实验配方

4% DMSO+30% PEG 300+water 3 mg/mL

细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源

A10 cells	30 μM	Function assay	24 hrs	Downregulation of Scd2 mRNA expression in rat A10 cells at 30 uM after 24 hrs by quantitative RT-PCR analysis	21401114
A10 cells	30 μM	Function assay	24 hrs	Down regulation of Prim2 mRNA expression in rat A10 cells at 30 uM after 24 hrs by quantitative RT-PCR analysis	21401114
A10 cells	30 μM	Function assay	24 hrs	Downregulation of Impk mRNA expression in rat A10 cells at 30 uM after 24 hrs by quantitative RT-PCR analysis	21401114
A549 cells		Cytotoxicity assay		Cytotoxicity against human A549 cells by SRB assay, IC50=6.27 μM	20594848
Bel7402 cells		Function assay	12 h	Induction of LDLR protein in human Bel7402 cells after 12 hrs by RT-PCR assay relative to control	19090767
CEM cells		Cytotoxicity assay	48 hrs	Cytotoxicity against human CEM cells expressing green fluorescent protein after 48 hrs by MTT assay, CC50=2.09 μM	21295891
G402 cells		Growth inhibition assay	48 hrs	Growth inhibition against human G402 cells after 48 hrs by MTT assay, GI50=11.87 μM	21401114
HCT15 cells		Cytotoxicity assay		Cytotoxicity against human HCT15 cells by SRB assay, IC50=16.59 μM	20594848
HepG2 cells	10 ug/mL	Function assay	12 h	Induction of LDLR protein expression in human HepG2 cells at 10 ug/mL after 12 hrs by flow cytometry	19090767
HepG2 cells	10 μM	Function assay	4 h	Increase in AMPKalpha phosphorylation in human HepG2 cells at 10 uM after 4 hrs by Western blot analysis relative to untreated control	23058107
HepG2 cells	10 μM	Function assay	4 h	Increase in total AMPKalpha level in human HepG2 cells at 10 uM after 4 hrs by Western blot analysis relative to untreated control	23058107
HepG2 cells	20 μM	Function assay	24 hrs	Induction of apoptosis in human HepG2 cells assessed as morphological changes at 20 uM after 24 hrs using Hoechst 33258 staining by fluorescence microscopic analysis	23182088
HepG2 cells		Cytotoxicity assay	24 hrs	Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay, IC50=11.22 μM	23182088
HepG2 cells		Cytotoxicity assay	48 hrs	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50=8.32 μM	23182088
HepG2-A16-CD81 cells	10 μM	Function assay		NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence.	22096101
HepG2-A16-CD81 cells	10 μM	Function assay		NOVARTIS: Antimalarial liver stage activity measured as reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells by immuno-fluorescence, and median schizont size at 10uM compound concentration, IC50=0.548 μM	22096101
HL60 cells		Apoptosis assay	48 hrs	Induction of apoptosis in human HL60 cells after 48 hrs using annexin V-propidium iodide staining by FACS analysis	20227144
HT-29 cells		Cytotoxicity assay	48 hrs	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay, IC50=8.45 μM	23182088
human CEM cells		Function assay	7 days	Antiviral activity against 0.05 MOI Human immunodeficiency virus 1 NL4.3 infected in human CEM cells expressing green fluorescent protein assessed as p24 antigen production measured 7 days post infection by ELISA, EC50=0.13 μM	21295891
KB cells		Cytotoxicity assay	72 h	Cytotoxicity against human KB cells after 72 hrs, IC50=7.32 μM	11141105
MRC5 cells		Function assay		Antiviral activity against HCMV in MRC5 cells by plaque reduction assay, IC50=0.68 μM	17239594
MRC5 cells	10 μM	Proliferation assay	54 hrs	Inhibition of HCMV proliferation in MRC5 cells after 54 hrs post-infection at 10 uM by plaque assay	17239594
MRC5 cells	10 μM	Proliferation assay	24 h	Inhibition of HCMV proliferation in MRC5 cells after 24 hrs post-infection at 10 uM by plaque assay	17239594
RKN cells		Growth inhibition assay	48 hrs	Growth inhibition against human RKN cells after 48 hrs by MTT assay, GI50=49.6 μM	21401114
SK-MEL-2 cells		Cytotoxicity assay		Cytotoxicity against human SK-MEL-2 cells by SRB assay, IC50=13.76 μM	20594848
SKN cells		Growth inhibition assay	72 h	Growth inhibition against human SKN cells after 72 hrs by MTT assay, GI50=15.88 μM	21401114
SKOV3 cells		Cytotoxicity assay		Cytotoxicity against human SKOV3 cells by SRB assay, IC50=16.44 μM	20594848

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02969070	Hypercholesterolemia ... 展开 >> Endothelial Dysfunction 收起 <<	Phase 3	Unknown	March 2017	Italy ... 展开 >> University of Naples "Federico II" Recruiting Naples, Italy, 80131 Contact: Giuseppe Giugliano, MD, PhD +390817462240 giuseppe.giugliano@unina.it Sub-Investigator: Raffaele Izzo, MD Sub-Investigator: Maurizio Galderisi, MD Sub-Investigator: Giuseppe Giugliano, MD, PhD 收起 <<
NCT02861261	Type 2 Diabetes	Phase 3	Active, not recruiting	August 2018	China, Shanghai ... 展开 >> Ruijin hospital,Shanghai Jiao Tong University School of Medicine Shanghai, Shanghai, China 收起 <<
NCT03378934	Coronary Artery Disease ... 展开 >> Percutaneous Coronary Intervention 收起 <<	Phase 4	Recruiting	April 2020	China, Beijing ... 展开 >> Peking Union Medical College Hospital Recruiting Beijing, Beijing, China, 100730 Contact: Zhenyu Liu, M.D. +861069155068 pumch_lzy@163.com Contact: Lihong Xu, B.N. +861069155068 xulihong1990@163.com 收起 <<
NCT03251716	Metabolic Syndrome ... 展开 >> Female Schizophrenia 收起 <<	Not Applicable	Completed	-	China, Tianjin ... 展开 >> Tianjin Anding Hospital Tianjin, Tianjin, China, 300222 收起 <<
NCT02296021	Gastritis Pep... 展开 >>tic Ulcer Dyspepsia 收起 <<	Phase 4	Completed	-	China, Shanxi ... 展开 >> Xijing Hospital of Digestive Diseases Xi'an, Shanxi, China, 710032 收起 <<
NCT03029390	Prediabetes I... 展开 >>mpaired Fasting Glucose Impaired Glucose Tolerance 收起 <<	Phase 4	Active, not recruiting	May 2018	Mexico ... 展开 >> Instituto de Terapeútica Experimental y Clínica. Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara Guadalajara, Jalisco, Mexico, 44340 收起 <<
NCT02084004	Type 2 Diabetes Mellitus	Phase 2 Phase 3	Withdrawn(The sponsor have not... 展开 >> enough money to support this trial) 收起 <<	April 2018	China, Shaanxi ... 展开 >> Second Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi, China, 710004 The 323rd Hospital of People's Liberation Army Xi'an, Shaanxi, China, 710054 First Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi, China, 710061 Shaanxi Provincial People's Hospital Xi'an, Shaanxi, China, 710068 收起 <<
NCT02633930	Gastritis Pep... 展开 >>tic Ulcer Dyspepsia 收起 <<	Phase 4	Completed	-	China, Shanxi ... 展开 >> Xijing Hospital of Digestive Diseases Xi'an, Shanxi, China, 710032 Xijing Hospital of Digestive Disease Xi'an, Shanxi, China, 710032 收起 <<
NCT02365480	Ulcerative Colitis	Phase 1	Active, not recruiting	-	United States, Illinois ... 展开 >> Northwestern University Chicago, Illinois, United States, 60611 China, Shaanxi Fourth Military Medical University Xi'an, Shaanxi, China, 710032 收起 <<
NCT02226185	Colorectal Adenoma	Phase 2 Phase 3	Active, not recruiting	June 2019	China ... 展开 >> Shanghai Institute of Digestive Disease Shanghai, China, 200001 收起 <<
NCT03333265	Colorectal Adenomas	Phase 2 Phase 3	Recruiting	December 31, 2020	China, Shaanxi ... 展开 >> Xijing Hospital of Digestive Disease Recruiting Xi'an, Shaanxi, China, 710032 Contact: xiaohua li, MD, PH.D 13474299901 lixiaohua1982@fmmu.edu.cn Contact: ying zhang, MD, PH.D 13310980140 收起 <<
NCT02082756	Prediabetes	Phase 2 Phase 3	Withdrawn(The sponsor have not... 展开 >> enough money to support this trial) 收起 <<	April 2018	China, Shaanxi ... 展开 >> First Affiliated Hospital of Xi'an Jiaotong University Xi'an,, Shaanxi, China, 710061 Second Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi, China, 710004 The 323rd Hospital of People's Liberation Army Xi'an, Shaanxi, China, 710054 Shaanxi Provincial People's Hospital Xi'an, Shaanxi, China, 710068 收起 <<
NCT03330184	Berberine Hydrochloride	Phase 3	Completed	-	China, Shaanxi ... 展开 >> First Affiliated Hospital of Xi'an Jiaotong University Xi'an,, Shaanxi, China, 710061 Second Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi, China, 710004 Shaanxi Provincial People's Hospital Xi'an, Shaanxi, China, 710068 收起 <<
NCT03281096	Colorectal Adenomas	Phase 2 Phase 3	Recruiting	March 1, 2021	China, Shaanxi ... 展开 >> Xijing Hospital of Digestive Disease Recruiting Xi'an, Shaanxi, China, 710032 Contact: xiaohua li, MD, PH.D 13474299901 lixiaohua1982@fmmu.edu.cn Contact: ying zhang, MD, PH.D 13310980140 收起 <<

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Berberine chloride/盐酸小檗碱实验方案

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