BVT 2733
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货号：A959730
BVT 2733 is a small molecule, non-steroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1(11β-HSD1).
BVT 2733 化学结构
BVT 2733 3D分子结构
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会员价
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BVT 2733 纯度/质量文件 产品仅供科研
货号：A959730
标准纯度：
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BVT 2733 质控信息
Trilostane
✔
99+%
AGI-6780
+++
IDH2 R140Q mutant, IC50: 23 nM
99%+
Gimeracil
✔
98%
AGI-5198
++
R132C-IDH1, IC50: 0.16 μM
R132H-IDH1, IC50: 70 nM
99%+
SW033291
++++
15-PGDH, IC50: 1.5 nM
15-PGDH, Ki: 0.1 nM
99%+
Mycophenolic acid
✔
99+%
Fomepizole
✔
98%
Leflunomide
✔
98%
3-Nitropropanoic acid
✔
99%+
Isovaleramide
✔
99%
Mycophenolate Mofetil
+++
Inosine monophosphate dehydrogenase II, IC50: 27 nM
Inosine monophosphate dehydrogenase I, IC50: 39 nM
98%
MK-8245
++++
SCD1 (mouse), IC50: 1 nM
SCD1 (rat), IC50: 3 nM
99%+
Vidofludimus
++
Human DHODH, IC50: 134 nM
99%+
Emodin
✔
98%
Ivosidenib
✔
98%
NCT-501
++
98%
Gossypol
✔
99%+
Devimistat
✔
98%
Disulfiram
✔
98%+
Enasidenib
++++
98%
PluriSIn 1
✔
99%+
ML390
+
99%+
Teriflunomide
✔
99%+
Daidzin
+++
98+%
18β-Glycyrrhetinic acid
✔
99%
RRx-001
✔
95%
NCT-503
+
99%+
Vorasidenib
✔
99%+
Ammonium Glycyrrhizinate(x:1)
✔
98+%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
BVT 2733 生物活性
描述
BVT.2733 is a new, small molecule, non-steroidal, isoform-selective inhibitor of mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). It lowered hepatic PEPCK and glucose-6-phosphatase mRNA, blood glucose and serum insulin concentrations compared with vehicle treated mice[4] in vivo [5] [6]
BVT 2733 动物研究
Dose
Mice: 100 mg/kg[3] [4]
Administration
p.o.
BVT 2733 参考文献
[1] Alberts P, Engblom L, et al. Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia. 2002 Nov;45(11):1528-32. Epub 2002 Sep 18.
[2] Wang L, Liu J, et al. BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice. PLoS One. 2012;7(7):e40056.
[3] Zhang L, Dong Y, et al. 11β-Hydroxysteroid dehydrogenase 1 inhibition attenuates collagen-induced arthritis. Int Immunopharmacol. 2013 Nov;17(3):489-94.
[4] Alberts P, Engblom L, Edling N, Forsgren M, Klingström G, Larsson C, Rönquist-Nii Y, Ohman B, Abrahmsén L. Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia. 2002 Nov;45(11):1528-32. doi: 10.1007/s00125-002-0959-6. Epub 2002 Sep 18. PMID: 12436336.
[5] Wang L, Liu J, Zhang A, Cheng P, Zhang X, Lv S, Wu L, Yu J, Di W, Zha J, Kong X, Qi H, Zhong Y, Ding G. BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice. PLoS One. 2012;7(7):e40056. doi: 10.1371/journal.pone.0040056. Epub 2012 Jul 2. PMID: 22768329; PMCID: PMC3388048.
[6] Zhang L, Dong Y, Zou F, Wu M, Fan C, Ding Y. 11β-Hydroxysteroid dehydrogenase 1 inhibition attenuates collagen-induced arthritis. Int Immunopharmacol. 2013 Nov;17(3):489-94. doi: 10.1016/j.intimp.2013.07.015. Epub 2013 Aug 11. PMID: 23938253.
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BVT 2733 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.33mL
0.47mL
0.23mL
11.66mL
2.33mL
1.17mL
23.31mL
4.66mL
2.33mL
BVT 2733 技术信息
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