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描述 | Idiopathic pulmonary fibrosis (IPF) causes irreversible loss of lung function. The lysophosphatidic acid receptor 1 (LPA1) pathway is implicated in IPF etiology. BMS-986020 is a high-affinity LPA1 antagonist under assessment in a phase 2 study in patients with IPF[2]. A BMS-986020 concentration-dependent displacement of [18F]BMT-083133 binding was observed in LPA1+ cells and lung sections. At 0.1 nM of BMS-986020, the percent displacement in healthy mice, bleomycin mice, and IPF lungs was 18%, 24%, and 31%, respectively; and at 10 nM, the percent displacement was 73%, 76%, and 64%, respectively[3]. Patients treated with BMS-986020 (600 mg for 26 weeks) experienced a significantly slower rate of decline in FVC vs placebo. Dose-related elevations in hepatic enzymes were observed in both BMS-986020 treatment groups[2]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.07mL 0.41mL 0.21mL |
10.36mL 2.07mL 1.04mL |
20.72mL 4.14mL 2.07mL |
CAS号 | 1257213-50-5 |
分子式 | C29H26N2O5 |
分子量 | 482.53 |
SMILES Code | O=C(C1(C2=CC=C(C3=CC=C(C4=C(NC(O[C@@H](C5=CC=CC=C5)C)=O)C(C)=NO4)C=C3)C=C2)CC1)O |
MDL No. | MFCD30489743 |
别名 | AM152; AM-000152; AP-3152 free acid |
运输 | 蓝冰 |
InChI Key | GQBRZBHEPUQRPL-LJQANCHMSA-N |
Pubchem ID | 49792850 |
存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry,2-8°C |
溶解方案 |
请根据您的动物给药指南选择适当的溶解方案。 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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