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Azithromycin/阿奇霉素 {[allProObj[0].p_purity_real_show]}

货号:A175409 同义名: 阿奇霉素 / CP 62993; CP 62,993

Azithromycin is an antibiotic for inhibition of parasite growth with IC50 of 8.4 μM.

Azithromycin/阿奇霉素 化学结构 CAS号:83905-01-5
Azithromycin/阿奇霉素 化学结构
CAS号:83905-01-5
Azithromycin/阿奇霉素 3D分子结构
CAS号:83905-01-5
Azithromycin/阿奇霉素 化学结构 CAS号:83905-01-5
Azithromycin/阿奇霉素 3D分子结构 CAS号:83905-01-5
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Azithromycin/阿奇霉素 纯度/质量文件 产品仅供科研

货号:A175409 标准纯度: {[allProObj[0].p_purity_real_show]}
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Azithromycin/阿奇霉素 生物活性

描述 Azithromycin, at a concentration of 2 µM, enhances rhinovirus-induced IFNβ expression in primary bronchial epithelial cells from individuals with asthma. This effect is tied to the upregulation of RIG-I like receptors and suppression of viral replication. The knockdown of MDA5, but not RIG-I, reduces the azithromycin-enhanced viral-induced IFNβ expression in these cells[1]. Azithromycin also specifically lowers MMP-9 mRNA and protein levels without influencing NF-κB activity in endotoxin-challenged monocytic THP-1 cells[2].

Azithromycin/阿奇霉素 动物研究

Animal study At a dose of 50 mg/kg, Azithromycin does not affect bronchoalveolar lavage inflammatory parameters nor LDH levels in a mouse model of asthma exacerbation. It does not induce general inflammatory parameters or LDH release in such models but increases the expression of interferon-stimulated genes and the pattern recognition receptor MDA5, without affecting RIG-I[1].

Azithromycin/阿奇霉素 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03682653 Childhood Mortality Phase 4 Not yet recruiting February 2022 -
NCT00865670 Infection Phase 1 Completed - -
NCT02344628 Yaws Phase 3 Completed - Ghana ... 展开 >> School Based Recruitment Ayensuanor District, Eastern Region, Ghana School Based Recruitment Upper West Akyem, Eastern Region, Ghana School Based Recruitment West Akyem District, Eastern Region, Ghana School Based Recruitment Nkwanta North District, Volta Region, Ghana Papua New Guinea Community Based Recruitment Karkar District, Madang Province, Papua New Guinea Community Based Recruitment Kavieng Subdistrict, New Ireland Province, Papua New Guinea United Kingdom London School of Hygiene and Tropical Medicine London, United Kingdom, WC1E 7HT 收起 <<

Azithromycin/阿奇霉素 参考文献

[1]Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18.

[2]Vandooren J, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3;12(4):e0174853.

Azithromycin/阿奇霉素 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.34mL

0.27mL

0.13mL

6.68mL

1.34mL

0.67mL

13.35mL

2.67mL

1.34mL

Azithromycin/阿奇霉素 技术信息

CAS号83905-01-5
分子式C38H72N2O12
分子量 748.98
SMILES Code C[C@@H]([C@@H]([C@@](C(O[C@@H]([C@@](C)(O)[C@@H]1O)CC)=O)([H])C)O[C@@](O[C@@H](C)[C@@H]2O)([H])C[C@@]2(C)OC)[C@H]([C@](O)(C[C@H](CN([C@@H]1C)C)C)C)O[C@@](O[C@H](C)C[C@@H]3N(C)C)([H])[C@@H]3O
MDL No. MFCD00873574
别名 阿奇霉素 ;CP 62993; CP 62,993; Z-Pak
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C

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