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首页 / 抑制剂/激动剂 / 代谢酶 / HMGCR / Atorvastatin/阿托伐他汀

Atorvastatin/阿托伐他汀 {[allProObj[0].p_purity_real_show]}

货号：A430758 同义名： 阿伐他汀

Atorvastatin is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol.

Atorvastatin/阿托伐他汀 化学结构 CAS号：134523-00-5
Atorvastatin/阿托伐他汀 化学结构
CAS号：134523-00-5
Atorvastatin/阿托伐他汀 3D分子结构
CAS号：134523-00-5
Atorvastatin/阿托伐他汀 化学结构 CAS号：134523-00-5
Atorvastatin/阿托伐他汀 3D分子结构 CAS号：134523-00-5
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Atorvastatin/阿托伐他汀 纯度/质量文件 产品仅供科研

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Atorvastatin/阿托伐他汀 生物活性

描述 Atorvastatin inhibits pre-proET-1 mRNA expression in a concentration- and time-dependent fashion (60-70% maximum inhibition) and reduces immunoreactive ET-1 levels (25-50%), this inhibitory effect is maintained in the presence of oxidized LDL (1-50 mg/mL). Atorvastatin significantly reduces angiotensin II-induced and epidermal growth factor-induced ROS production in VSMCs. Atorvastatin downregulates mRNA expression of the NAD(P)H oxidase subunit nox1 in VSMCs, whereas p22phox mRNA expression is not significantly altered. Atorvastatin inhibits membrane translocation of rac1 GTPase, which is required for the activation of NAD(P)H oxidase. Atorvastatin (0.1 μM) significantly diminishes NF-κB activation induced by Ang II and TNF-α in mononuclear cells and VSMC. Atorvastatin (1 μM) diminishes MCP-1 expression induced by Ang II, TNF-α and is reversed by Mevalonate only in Ang II-stimulated cells. Atorvastatin (1 μM) diminishes IP-10 expression induced by Ang II and by TNF-α in VSMC, and this reduction is partially reversed by Mevalonate. Atorvastatin and Gemfibrozil metabolites, but not the parent drugs, are potent antioxidants against lipoprotein oxidation.[1-2]

Atorvastatin/阿托伐他汀 动物研究

Dose Rats: 10 mg/kg, max = 20 mg/kg[3]
Administration p.o.
Toxicity (LD50) Rats: 40 mg/kg p.o.[3]

Atorvastatin/阿托伐他汀 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00768638 Chronic Kidney Disease Phase 4 Completed - Canada ... 展开 >> Hôtel-Dieu de Québec Hospital Quebec, Canada, G1R2J6 收起 <<
NCT02497638 Prostate Cancer Phase 2 Not yet recruiting December 2022 Canada, Ontario ... 展开 >> Princess Margaret Cancer Centre Recruiting Toronto, Ontario, Canada, M5G 2M9 Principal Investigator: Robert Hamilton, MD, MPH, FRCSC          Principal Investigator: Neil Fleshner, MD, MPH, FRCSC 收起 <<
NCT00974740 Type 1 Diabetes Phase 1 Terminated(for lack of recruit... 展开 >>ment) 收起 << - Germany ... 展开 >> Diabetes-Zentrum Mergentheim Bad Mergentheim, Germany, 97980 Gemeinschaftskrankenhaus Havelhöhe Berlin, Germany, 14089 Helios Klinikum Emil von Behring Berlin, Germany, 14165 Praxis Dr. Friedhelm Schmitten Bestwig-Ramsbeck, Germany, 59909 DDZ Deutsches Diabetes Zentrum Düsseldorf, Germany, 40221 St. Josefs Krankenhaus Heidelberg, Germany, 69115 St. Antonius Krankenhaus, Med. Klinik Köln, Germany, 50968 Praxisklinik Leipzig Leipzig, Germany, 04103 Praxis Dr. Gerhard Willms Leverkusen, Germany, 51373 Praxis Dr. Heinz-Georg Ley Marl, Germany, 45770 Diabetologische Schwerpunktpraxis, Angiologie Münster, Germany, 48145 Praxis Dr. Werner Stürmer Würzburg, Germany, 97070 收起 <<

Atorvastatin/阿托伐他汀 参考文献

[1]Colhoun HM, Betteridge DJ, et al. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet. 2004;364(9435):685-96.

[2]Zhang L, He H, Balschi JA. Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration. Am J Physiol Heart Circ Physiol. 2007;293(1):H457-66.

[3]Crespo MJ, Quidgley J. Simvastatin, atorvastatin, and pravastatin equally improve the hemodynamic status of diabetic rats. World J Diabetes. 2015;6(10):1168-78.

Atorvastatin/阿托伐他汀 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.79mL

0.36mL

0.18mL

8.95mL

1.79mL

0.90mL

17.90mL

3.58mL

1.79mL

Atorvastatin/阿托伐他汀 技术信息

CAS号134523-00-5
分子式C33H35FN2O5
分子量 558.64
SMILES Code [C@@H](CC[N]1C(=C(C(=C1C(C)C)C(NC2=CC=CC=C2)=O)C3=CC=CC=C3)C4=CC=C(C=C4)F)(C[C@H](CC(O)=O)O)O
MDL No. MFCD00899261
别名 阿伐他汀
运输蓝冰
InChI Key XUKUURHRXDUEBC-KAYWLYCHSA-N
Pubchem ID 60823
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, 2-8°C

Tags: Atorvastatin | 阿伐他汀 | HMGCR | AmBeed-信号通路专用抑制剂 | Atorvastatin/阿托伐他汀 纯度/质量文件 | Atorvastatin/阿托伐他汀 生物活性 | Atorvastatin/阿托伐他汀 动物研究 | Atorvastatin/阿托伐他汀 临床数据 | Atorvastatin/阿托伐他汀 参考文献 | Atorvastatin/阿托伐他汀 实验方案 | Atorvastatin/阿托伐他汀 技术信息

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