Astilbin is a flavonoid compound that can enhance NRF2 activition with anti-inflammatory properties. It could be extracted from chinese astilbe. Astilbin has been found to have significant immunosuppressive effects in recent years.
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Astilbin, a flavonoid compound, is isolated from the rhizome of Smilax glabra. Astilbin markedly inhibited cisplatin-induced cell apoptosis and recovered cell growth. Astilbin could ameliorate the cisplatin-induced nephrotoxicity by reducing oxidative stress and inflammation[3]. In addition, kidney function parameters, including serum creatinine (Scr) and blood urea nitrogen (BUN) were restored in astilbin-treated hyperuricemic rats. Astilbin prevented the renal damage against the expression of Thioredoxin-interacting protein (TXNIP) and its related inflammation signal pathway, including NLR pyrin domain-containing 3/Nuclear factor κB (NLRP3/NF-κB), which is associated with the up-regulation of interleukin-1β (IL-1β) and interleukin-18 (IL-18), and also presented a renal protective role by suppression oxidative stress[4]. Astilbin may be a promising agent for psoriasis treatment. Astilbin leads to S phase arrest of the cell cycle by induction of p53 and p21 and activated-AMPK. Moreover, astilbin regulates the expression of VEGF in human HaCaT keratinocytes[5]. The absolute bioavailability of astilbin was improved from 0.32 to 4.40% in rats through nanoparticle fabrication[6].
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