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/ Calcium Channel / Aranidipine/阿雷地平

Aranidipine/阿雷地平 {[allProObj[0].p_purity_real_show]}

货号：A577801 同义名： MPC1304

Aranidipine is a long-acting, potent antihypertensive agent that works by blocking Ca2+ entry into cells.

Aranidipine/阿雷地平 化学结构 CAS号：86780-90-7
Aranidipine/阿雷地平 化学结构
CAS号：86780-90-7
Aranidipine/阿雷地平 3D分子结构
CAS号：86780-90-7
Aranidipine/阿雷地平 化学结构 CAS号：86780-90-7
Aranidipine/阿雷地平 3D分子结构 CAS号：86780-90-7
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Aranidipine/阿雷地平 纯度/质量文件 产品仅供科研

货号：A577801 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

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产品名称 Ca2+ channel-like protein ↓ Calcium Channel ↓ Cav 2.2 ↓ 其他靶点 纯度
CDC25B-IN-2 ✔ Akt 99%+
Clevidipine ✔ 97%
Verapamil HCl ✔ 99%
Amlodipine ✔ 99%
Amlodipine maleate ✔ 98%
(+)-cis-Diltiazem HCl ✔ 99%
Zegocractin ++

Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM

 		99%+
Tanshinone IIA sulfonate sodium ✔ 98%
Ulixacaltamide ++

hCaV3.1, IC50: 50 nM

hCaV3.2, IC50: 110 nM

 		99%+
Dronedarone HCl ✔ 95%
Nitrendipine +

Calcium channel, IC50: 95 nM

 		98%
Efonidipine HCl monoethanolate ✔ 98%
Cinnarizine ✔ 98%
SEA0400 ++

NCX, IC50: 33 nM

 		ERK,ROS,p38 MAPK 99%+
Fasudil HCl ✔ Rho,PKA 98%
ML-9 ✔ MLCK,Akt 99%+
Flunarizine 2HCl +

Calcium channel, Ki: 68 nM

 		95%
Lomerizine 2HCl ✔ 98%
Efonidipine ✔ 98%
Levamlodipine ✔ 98%
Nisoldipine ++

L-type Cav1.2, IC50: 10 nM

 		97%
Isradipine ✔ 98%
Lacidipine ✔ 98%
Lercanidipine ✔ 99%
Loureirin B ✔ Potassium Channel 99%+
Tetracaine HCl ✔ 98%
Manidipine +++

Calcium channel, IC50: 2.6 nM

 		99%
Manidipine Dihydrochlorid +++

Calcium channel, IC50: 2.6 nM

 		98%
Nicardipine ✔ 99%
Wilforgine ✔ 98+%
Econazole ✔ 99%+
Ginsenoside Rd ✔ NF-κB 98%
Fendiline HCl ✔ 98+%
Mesaconitine ✔ 98%
Tetrandrine ✔ 95%
Nifedipine ✔ 95%
Nilvadipine ++++

Calcium channel, IC50: 0.03 nM

 		98%
Barnidipine ++++

[3H]nitrendipine, Ki: 0.21 nM

 		95+%
Azelnidipine ✔ 97%
Levetiracetam ✔ 98%
Nimodipine ✔ 95%
Benidipine HCl ✔ 98%
Pinaverium bromide ✔ 98%
Pranidipine ✔ 99%
NP118809 +

L-type calcium channel, IC50: 12.2 μM

N-type Ca2+ channel, IC50: 0.11 μM

 		98%
Amlodipine Besylate +++

Calcium channel, IC50: 1.9 nM

 		97%
Cilnidipine ✔ 99%
Cinepazide Maleate ✔ 99% (HPLC)
Terfenadine ✔ 98%
YM-58483 ✔ 99%+
Ranolazine ✔ 98%
Praeruptorin A ✔ p38 MAPK,Akt 98%
Ranolazine 2HCl ✔ 98%
Felodipine ++++

L-type calcium channel, IC50: 0.15 nM

 		98%
PD173212 +++

N-type Ca2+ channel, IC50: 36 nM

 		98%
Levamlodipine besylate ✔ 97%
Carboxyamidotriazole Orotate ✔ 98%
IGS-1.76 ✔ 98+%
WH-4-023 ++++

Cav 2.2, IC50: 0.001 μM

 		++++

Cav 2.2, IC50: 0.001 μM

 		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Aranidipine/阿雷地平 生物活性

描述 Aranidipine, a newly developed calcium antagonist, possesses unique pharmacologic characteristics in that its metabolite (M-1) still has antihypertensive action. During norepinephrine-induced constriction, the addition of aranidipine dilated both afferent and efferent arterioles in a dose-dependent manner; at 10-6 M, 83 +/- 6% and 90 +/- 6% reversal, respectively. Aranidipine has dilator action on both arterioles, whereas M-1 caused predominant dilation of afferent arterioles[3]. Administration of aranidipine 5-20 mg/d can effectively control blood pressure and is not inferior to retard-released felodipine 5-10 mg/d. The efficacy of 20 mg/d aranidipine is superior to that of retard-released felodipine 5-10 mg/d. And the effectiveness and safety of aranidipine are similar to those of retard-released felodipine[4]. When infused into the renal artery in anesthetized dogs, aranidipine (0.03 mg/kg/min) induced sustained increases in urine volume and urinary excretion of sodium and of potassium. Aranidipine (0.3, 1, and 3 mg/kg), when administered orally, dose-dependently increased urine volume and urinary excretion of electrolytes in conscious saline-loaded SHRs[5].

Aranidipine/阿雷地平 参考文献

[1]Chen L, Jiang H, et al. [The effects of aranidipine on ambulatory blood pressures in patients with mild to moderate essential hypertension] . Zhonghua Nei Ke Za Zhi. 2013 Sep;52(9):749-52. Chinese.

[2]Masumiya H, Tanaka Y, et al. Inhibition of T-type and L-type Ca(2+) currents by aranidipine, a novel dihydropyridine Ca(2+) antagonist. Pharmacology. 2000 Aug;61(2):57-61.

[3]Nakamura A, Hayashi K, Fujiwara K, Ozawa Y, Honda M, Saruta T. Distinct action of aranidipine and its active metabolite on renal arterioles, with special reference to renal protection. J Cardiovasc Pharmacol. 2000 Jun;35(6):942-8

[4]Jiao Y, Chen L, Zheng JT, Ke YN, Wang Y, Yang HY, Jin H, Zhao XL, Liu MX, Wang L, Wang BY, Li DY. [Efficacy and safety of aranidipine in Chinese patients with mild-to-moderate essential hypertension]. Zhonghua Yi Xue Za Zhi. 2013 Oct 22;93(39):3104-10. Chinese

[5]Ichihara K, Okumura K, Kamei H, Nagasaka M, Kanda A, Kanno T, Miyoshi K, Miyake H. Renal effects of the calcium channel blocker aranidipine and its active metabolite in anesthetized dogs and conscious spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1998 Feb;31(2):277-85

Aranidipine/阿雷地平 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.57mL

0.51mL

0.26mL

12.87mL

2.57mL

1.29mL

25.75mL

5.15mL

2.57mL

Aranidipine/阿雷地平 技术信息

CAS号86780-90-7
分子式C19H20N2O7
分子量 388.37
SMILES Code O=C(C1=C(C)NC(C)=C(C(OCC(C)=O)=O)C1C2=CC=CC=C2[N+]([O-])=O)OC
MDL No. MFCD00865813
别名 MPC1304
运输蓝冰
InChI Key NCUCGYYHUFIYNU-UHFFFAOYSA-N
Pubchem ID 2225
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, 2-8°C
溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二

Tags: Aranidipine | 86780-90-7 | MPC1304 | MPC 1304 | MPC-1304 | Calcium Channel Antagonist | Membrane Transporter/Ion Channel | Neuronal Signaling | Calcium Channel | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Aranidipine/阿雷地平 纯度/质量文件 | Aranidipine/阿雷地平 亚型比较 | Aranidipine/阿雷地平 生物活性 | Aranidipine/阿雷地平 参考文献 | Aranidipine/阿雷地平 实验方案 | Aranidipine/阿雷地平 技术信息

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