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Angiotensin II/血管紧张素II(人) {[allProObj[0].p_purity_real_show]}

货号：A594780 同义名： 血管紧张素II / Angiotensin II human; Ang II

Angiotensin II human is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure.

Angiotensin II/血管紧张素II(人) 化学结构 CAS号：4474-91-3
Angiotensin II/血管紧张素II(人) 化学结构
CAS号：4474-91-3
Angiotensin II/血管紧张素II(人) 3D分子结构
CAS号：4474-91-3
Angiotensin II/血管紧张素II(人) 化学结构 CAS号：4474-91-3
Angiotensin II/血管紧张素II(人) 3D分子结构 CAS号：4474-91-3
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Angiotensin II/血管紧张素II(人) 纯度/质量文件 产品仅供科研

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Angiotensin II/血管紧张素II(人) 生物活性

描述 Angiotensin II is a crucial vasoconstrictor and bioactive peptide of the renin/angiotensin system, playing a key role in human blood pressure regulation primarily through its interactions with G-protein-coupled receptors (GPCRs) AT1R and AT2R. It induces various physiological effects, including sympathetic nervous system stimulation, increased aldosterone biosynthesis and renal functions, and vascular and myocardial thickening due to enhanced collagen synthesis in fibroblasts. Additionally, it stimulates the growth of vascular smooth muscle cells and can lead to vascular fibrosis. Angiotensin II also induces capillary formation from endothelial cells through a LOX-1 dependent redox-sensitive pathway [1][2][3][4].

Angiotensin II/血管紧张素II(人) 动物研究

Animal study Angiotensin II is used in animal modeling to construct cardiovascular and cerebrovascular disease models. Angiotensin II (5 mL of 1 nM; intraperitoneal injection; 200-250 g Sprague-Dawley rats) induces significant neutrophil recruitment that peaks at 4 hours and resolves by 24 hours [4].To study the critical role of AT1 receptors in the pathogenesis of hypertension, osmotic minipumps are surgically implanted subcutaneously into each animal to continuously infuse Angiotensin II (1000 ng/kg/min) for 4 weeks. Angiotensin II causes hypertension primarily by activating AT1 receptors in the kidney, which promote sodium reabsorption [5].

Angiotensin II/血管紧张素II(人) 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02344602 Type 1 Diabetes Mellitus Phase 4 Completed - Canada, Ontario ... 展开 >> Renal Physiology Laboratory, University Health Network Toronto, Ontario, Canada, M5G 2N2 收起 <<
NCT01923597 Diabetic Nephropathy ... 展开 >> Hypertension 收起 << Phase 2 Completed - Brazil ... 展开 >> Unicamp Campinas, São Paulo, Brazil, 13084-971 收起 <<
NCT01371747 Chronic Kidney Disease ... 展开 >> Hypertension Hyperkalemia 收起 << Phase 2 Completed - -

Angiotensin II/血管紧张素II(人) 参考文献

[1]de Gasparo M, et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000 Sep;52(3):415-72.

[2]Fyhrquist F, et al. Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders. J Hum Hypertens. 1995 Nov;9 Suppl 5:S19-24.

[3]Hu C, et al. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway. Hypertension. 2007;50(5):952-957.

[4]Nabah YN, et al. Angiotensin II induces neutrophil accumulation in vivo through generation and release of CXC chemokines. Circulation. 2004;110(23):3581-3586.

[5]Crowley SD, et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17985-90.

Angiotensin II/血管紧张素II(人) 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.96mL

0.19mL

0.10mL

4.78mL

0.96mL

0.48mL

9.56mL

1.91mL

0.96mL

Angiotensin II/血管紧张素II(人) 技术信息

CAS号4474-91-3
分子式C50H71N13O12
分子量 1046.18
SMILES Code OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)=O)=O
MDL No. MFCD00161484
别名 血管紧张素II ;Angiotensin II human; Ang II; Asp-Arg-Val-Tyr-Ile-His-Pro-Phe.; Angiotensin II (human); DRVYIHPF
运输蓝冰
InChI Key CZGUSIXMZVURDU-JZXHSEFVSA-N
Pubchem ID 172198
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

Tags: Angiotensin II human | 4474-91-3 | Angiotensin II | Ang II | Induced Disease Models Products | GPCR/G Protein | Apoptosis | Cardiovascular System Disease Models | Angiotensin Receptor | Apoptosis | Hypertension Models | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Angiotensin II/血管紧张素II(人) 纯度/质量文件 | Angiotensin II/血管紧张素II(人) 生物活性 | Angiotensin II/血管紧张素II(人) 动物研究 | Angiotensin II/血管紧张素II(人) 临床数据 | Angiotensin II/血管紧张素II(人) 参考文献 | Angiotensin II/血管紧张素II(人) 实验方案 | Angiotensin II/血管紧张素II(人) 技术信息

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