货号:A119196
同义名:
两性霉素B
/ LNS-AmB; NSC 527017
Amphotericin B is a polyene, antifungal antibiotic produced from a strain of Streptomyces nodosus.
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描述 | Amphotericin B (AmB) is the most effective drug for treating many life-threatening fungal infections. TLR2 (Toll-like receptors) and CD14 are required for amphotericin B-dependent inflammatory stimulation of innate immune cells and that TLR4 may also provide stimulation of these cells[1]. AmB only kills unicellular Leishmania promastigotes (LPs) when aqueous pores permeable to small cations and anions are formed. At low concentrations (≤0.1 microM), AmB was found to be nonlethal against LPs but, above this concentration, leishmanias were rapidly killed[3]. Amphotericin B treatment of hamsters infected with scrapie strain 263K prolongs the incubation period of the disease [4]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT00163111 | Candidiasis | Phase 3 | Completed | - | - |
NCT00370825 | Visceral Leishmaniasis | Phase 2 | Completed | - | India ... 展开 >> Kala-azar Medical Research Center Muzaffarpur, Bihar, India, 842001 收起 << |
NCT00002742 | Chronic Myeloproliferative Dis... 展开 >>orders Infection Leukemia Lymphoma Multiple Myeloma and Plasma Cell Neoplasm Myelodysplastic Syndromes 收起 << | Phase 3 | Completed | - | - |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.08mL 0.22mL 0.11mL |
5.41mL 1.08mL 0.54mL |
10.82mL 2.16mL 1.08mL |
CAS号 | 1397-89-3 |
分子式 | C47H73NO17 |
分子量 | 924.08 |
SMILES Code | C[C@H]([C@@H](O)[C@@H](C)[C@H](C)OC1=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@]2([H])O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C[C@@]3([H])[C@H](C(O)=O)[C@@H](O)C[C@](C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C1)(O)O3 |
MDL No. | MFCD00877763 |
别名 | 两性霉素B ;LNS-AmB; NSC 527017; Fungizone |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C |
动物实验配方 |
IP 2% DMSO+2% Tween80+30% PEG300+water 1 mg/mL clear PO 0.5% CMC-Na 36 mg/mL suspension |