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/ Amitriptyline HCl/阿米替林盐酸盐

Amitriptyline HCl/阿米替林盐酸盐 {[allProObj[0].p_purity_real_show]}

货号：A315453 同义名： 盐酸阿米替林 / Amitriptyline (hydrochloride) (CRM); Ro 4-1517

Amitriptyline HCl is a multiple-target molecular as an inhibitor of both 5-HT and NA reuptake (SNRI), and also a TrkA/B agonist.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Amitriptyline HCl/阿米替林盐酸盐 化学结构 CAS号：549-18-8
Amitriptyline HCl/阿米替林盐酸盐 化学结构
CAS号：549-18-8
Amitriptyline HCl/阿米替林盐酸盐 3D分子结构
CAS号：549-18-8
Amitriptyline HCl/阿米替林盐酸盐 化学结构 CAS号：549-18-8
Amitriptyline HCl/阿米替林盐酸盐 3D分子结构 CAS号：549-18-8
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Amitriptyline HCl/阿米替林盐酸盐 纯度/质量文件 产品仅供科研

货号：A315453 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

更多 >
产品名称 5-HT ↓ 5-HT1 ↓ 5-HT2 ↓ 5-HT3 ↓ 5-HT5 ↓ 5-HT6 ↓ 5-HT7 ↓ 其他靶点 纯度
Desvenlafaxine ++

5-HT, Ki: 40.2 nM

 		98%
Lamotrigine +

5-HT (human platelets), IC50: 240 μM

5-HT (rat brain synaptosomes), IC50: 474 μM

 		98%
Venlafaxine ✔ 99%
Fluvoxamine maleate ✔ 99%
Iloperidone ✔ 99%
Ziprasidone HCl ✔ 98+%
Atomoxetine HCI +

5-HT, Ki: 77 nM

 		98%
Dapoxetine HCl ✔ 97%
Trazodone ✔ 98+%
Clomipramine HCl ✔ 98%
Mirtazapine ✔ 99+%
Escitalopram oxalate +++

5-HT, Ki: 0.89 nM

 		97%
Duloxetine ✔ 97%
Sertraline HCl ++

5-HT, Ki: 13 nM

 		98%
Citalopram HBr +++

serotonin reuptake, IC50: 1.8 nM

 		98%
Latrepirdine 2HCl ✔ GluR 99%
Fluoxetine HCl ✔ 99.5%
Paroxetine HCl ✔ AChR 99%
BMY 7378 ++

5-HT1A, pIC50: 6.4

5-HT1D, pIC50: 5.9

 		+

5-HT2, pIC50: 5.5

 		97%
Flibanserin +++

5-HT1A, Ki: 1 nM

 		+

5-HT2A, Ki: 49 nM

 		95%
LY310762 +

5-HT1D, Ki: 249 nM

 		99%+
Cyclobenzaprine HCI ✔ 99%
Blonanserin +++

5-HT2, Ki: 3.98 nM

 		99%
Cyproheptadine HCl ++++

5-HT2, IC50: 0.6 nM

 		99+%
Olanzapine ✔ 99+%
Pimavanserin hemitartrate +++

5-HT2A, pIC50: 8.7

 		99%
Ketanserin +++

5-HT2C (Rat), Ki: 50 nM

5-HT2C (Human), Ki: 2.5 nM

 		99%+
Loxapine succinate ++

5-HT2 (bovine), Ki: 6.6 nM

5-HT2 (human), Ki: 6.8 nM

 		98%
Agomelatine ✔ 98%
Clozapine ✔ 98%
Amitriptyline +

5-HT2, Ki: 235 nM

 		SERT 99%
PRX-08066 maleate +++

5-HT2B, IC50: 3.4 nM

 		98+%
RS-127445 ++++

5-HT2B, pKi: 9.5

5-HT2B, pIC50: 10.4

 		99%+
Sarpogrelate HCl ++++

5-HT2C, Kd: 1.1 nM

5-HT2A, Kd: 2.1 nM

 		98%
Tropisetron ✔ 99%
Ramosetron HCl ++++

5-HT3 receptor, Ki: 0.091 nM

 		98%
Ondansetron ✔ 99%
Granisetron ✔ 98%
Alosetron HCl ✔ 98%
Ondansetron HCl dihydrate ✔ 98%
VUF10166 ++++

5-HT3AB, Ki: 22 nM

5-HT3A, Ki: 0.04 nM

 		99%+
Azasetron HCl ++++

5-HT3, IC50: 0.33 nM

 		99%
Asenapine maleate +++

5-HT1B, pKi: 8.4

5-HT1A, pKi: 8.6

 		++++

5-HT2A, pKi: 9.75

5-HT2C, pKi: 10.46

 		+++

5-HT5A, pKi: 8.84

 		++++

5-HT6, pKi: 9.6

 		++++

5-HT7, pKi: 9.94

 		97%
Risperidone ++

5-HT1D, Ki: 84.6 nM

5-HT1B, Ki: 14.9 nM

 		++++

5-HT2A, Ki: 61.9 nM

5-HT2C, Ki: 12 nM

 		+

5-HT5A, Ki: 206 nM

 		++

5-HT7, Ki: 6.6 nM

 		98%
SB 271046 HCl +++

5-HT6, pKi: 8.92

 		99%+
Intepirdine ++++

5-HT6, pKi: 9.63

 		99%+
SB-269970 HCl ++

5-HT7, pKi: 8.3

 		98+%
BRL 15572 ++

5-HT1D, pKi: 6

5-HT1B, pKi: 6.1

 		++

5-HT2A, pKi: 6.6

5-HT2B, pKi: 6.2

 		+

5-HT6, pKi: 5.9

 		+

5-HT7, pKi: 6.3

 		95%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Amitriptyline HCl/阿米替林盐酸盐 生物活性

描述 Amitriptyline hydrochloride acts as an inhibitor of the serotonin reuptake transporter (SERT) and the noradrenaline reuptake transporter (NET), with inhibition constants (Kis) of 3.45 nM for SERT and 13.3 nM for NET in humans. Additionally, it has a low affinity for the dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also blocks adrenergic, muscarinic, histamine, and 5-HT receptors. It serves as an agonist for TrkA and TrkB receptors, demonstrating strong neurotrophic properties. Amitriptyline hydrochloride is recognized for its antidepressant efficacy[1].[2].[3].

Amitriptyline HCl/阿米替林盐酸盐 动物研究

Animal study Amitriptyline (15 mg/kg, i.p.) hydrochloride stimulates TrkA and TrkB receptors and obstructs neuronal apoptosis induced by Kainic acid in the brains of C57BL/6 mice[3].Amitriptyline (15-25 mg/kg, i.p., over 5 days) hydrochloride causes TrkA and TrkB receptors to form heterodimers in the mouse brain[3].Amitriptyline (15 mg/kg, i.p.) hydrochloride demonstrates an antinociceptive action by activating α2-adrenoceptors in mice[3].

Amitriptyline HCl/阿米替林盐酸盐 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03168022 Healthy Adults Phase 1 Completed - Canada ... 展开 >> InVentiv Health Clinique Inc. Quebec, Canada, GIP )A2 收起 <<
NCT02814565 Neck Pain Bac... 展开 >>k Pain Spasm 收起 << Phase 3 Completed - Russian Federation ... 展开 >> Lipetsk, Lipetsk region, Russian Federation Saransk, Republic of Mordovia, Russian Federation Kazan, Republic of Tatarstan, Russian Federation Ekaterinburg, Sverdlovsk region, Russian Federation Moscow, Russian Federation Nizhny Novgorod, Russian Federation Novosibirsk, Russian Federation Saint-Petersburg, Russian Federation Tver, Russian Federation Yaroslavl, Russian Federation 收起 <<
NCT01266733 Fibromyalgia Phase 2 Completed - Spain ... 展开 >> Hospital Galdakao-Usansolo Galdakao, Bizkaia, Spain, 48960 收起 <<

Amitriptyline HCl/阿米替林盐酸盐 参考文献

[1]Kim Lawson. A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia. Biomedicines. 2017 Jun; 5(2): 24.

[2]S Neil Vaishnavi , et al. Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biol Psychiatry. 2004 Feb 1;55(3):320-2.

[3]Jang, S.W., et al., Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol, 2009. 16(6): p. 644-56.

Amitriptyline HCl/阿米替林盐酸盐 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.19mL

0.64mL

0.32mL

15.93mL

3.19mL

1.59mL

31.86mL

6.37mL

3.19mL

Amitriptyline HCl/阿米替林盐酸盐 技术信息

CAS号549-18-8
分子式C20H24ClN
分子量 313.86
SMILES Code CN(C)CC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13.[H]Cl
MDL No. MFCD00012537
别名 盐酸阿米替林 ;Amitriptyline (hydrochloride) (CRM); Ro 4-1517; NIH 10794; Amitriptyline hydrochloride
运输蓝冰
InChI Key KFYRPLNVJVHZGT-UHFFFAOYSA-N
Pubchem ID 11065
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C
溶解方案 配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案一

Tags: Amitriptyline | 549-18-8 | Serotonin Transporter Inhibitor | Neuronal Signaling | GPCR/G Protein | Immunology/Inflammation | Membrane Transporter/Ion Channel | Protein Tyrosine Kinase/RTK | Serotonin Transporter | 5-HT Receptor | Histamine Receptor | mAChR | Adrenergic Receptor | Sodium Channel | Trk Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Amitriptyline HCl/阿米替林盐酸盐 纯度/质量文件 | Amitriptyline HCl/阿米替林盐酸盐 亚型比较 | Amitriptyline HCl/阿米替林盐酸盐 生物活性 | Amitriptyline HCl/阿米替林盐酸盐 临床数据 | Amitriptyline HCl/阿米替林盐酸盐 参考文献 | Amitriptyline HCl/阿米替林盐酸盐 实验方案 | Amitriptyline HCl/阿米替林盐酸盐 技术信息

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