Amifampridine is a quaternary ammonium compound that blocks presynaptic potassium channels, subsequently prolongs the action potential and increases presynaptic calcium concentrations, it was approved by the US FDA for the treatment of adults with LEMS.
HazMat Fee +
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Amifampridine (3,4-Diaminopyridine) is an orally active, potent, and cell-permeable blocker of voltage-gated potassium (Kv) channels. It is effective in reversing BoNT/A intoxication, enhancing transmitter release from neuromuscular junctions (NMJs), and can be utilized in research related to Lambert-Eaton myasthenic syndrome (LEMS)[1][2][3].
Amifampridine/3,4-二氨基吡啶 动物研究
Animal study
A single oral gavage of Amifampridine (at 10 mg/kg) can counteract muscle paralysis induced by BoNT/A intoxication[2].Following intravenous administration at 2.5 mg/kg or oral gavage at 10 mg/kg, Amifampridine exhibits a plasma half-life of 1 hour and approximately 57% bioavailability (F) in mice[2].Amifampridine has a brief plasma half-life and may induce seizures at high concentrations after crossing the blood-brain barrier[2].
搜索
HazMat Fee +
