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Amezinium methylsulfate {[allProObj[0].p_purity_real_show]}

货号:A313059 同义名: Amezinium metilsulfate; Lu-1631

Amezinium methylsulfate can stimulate α and β-1 receptors and inhibit noradrenaline and tyramine uptake, used as a sympathomimetic drug for the treatment of low blood pressure.

Amezinium methylsulfate 化学结构 CAS号:30578-37-1
Amezinium methylsulfate 化学结构
CAS号:30578-37-1
Amezinium methylsulfate 3D分子结构
CAS号:30578-37-1
Amezinium methylsulfate 化学结构 CAS号:30578-37-1
Amezinium methylsulfate 3D分子结构 CAS号:30578-37-1
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Amezinium methylsulfate 纯度/质量文件 产品仅供科研

货号:A313059 标准纯度: {[allProObj[0].p_purity_real_show]}
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Amezinium methylsulfate 生物活性

描述 Amezinium metilsulfate is a sympathomimetic drug used for the treatment of low blood pressure. During spinal/epidural anaesthesia 5 mg amezinium is given i.v. if blood pressure dropped greater than 20 mmHg. Amezinium proves a stimulating drug for alpha- and beta 1-receptors by stabilising the systemic blood pressure in spinal/epidural anaesthesia[3]. Amezinium metilsulfate most probably stimulates both alpha1B-receptors in the vascular wall and alpha1A/D-receptors in the proximal urethra[4]. Moreover, amezinium is of therapeutic value for the treatment of neurogenic orthostatic hypotension[5].

Amezinium methylsulfate 参考文献

[1]Kitano Y, Nomura S, et al. Leg ulceration during amezinium methylsulfate therapy for hypotension in a hemodialyzed patient with generalized vascular calcification. Nephron. 1995;71(1):115.

[2]Nambu K, Yoshida K, et al. Disposition and metabolism of [14C] -amezinium metilsulfate in rats. Arzneimittelforschung. 1988 Jul;38(7):909-18.

[3]Schaps D, Seitz W, Mehler D, Tholen A, Goroll D. Therapeutische Anwendung von Ameziniummetilsulfat--einem neuen, langwirkenden Sympathikomimetikum--bei rückenmarksnaher Leitungsanästhesie [Therapeutic use of amezinium methylsulfate--a new, long acting, sympathomimetic--in paraspinal conduction anesthesia]. Anasth Intensivther Notfallmed. 1984 Oct;19(5):235-9. German. PMID: 6517242.

[4]Sakakibara R, Uchiyama T, Asahina M, Yoshiyama M, Yamanishi T, Hattori T. Amezinium metilsulfate, a sympathomimetic agent, may increase the risk of urinary retention in multiple system atrophy. Clin Auton Res. 2003 Feb;13(1):51-3.

[5]Kita K, Hirayama K. Treatment of neurogenic orthostatic hypotension with amezinium metilsulfate, a new indirect sympathomimetic drug. Neurology. 1988 Jul;38(7):1095-9.

Amezinium methylsulfate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.19mL

0.64mL

0.32mL

15.96mL

3.19mL

1.60mL

31.92mL

6.38mL

3.19mL

Amezinium methylsulfate 技术信息

CAS号30578-37-1
分子式C12H15N3O5S
分子量 313.33
SMILES Code COC1=CC(N)=CN=[N+]1C2=CC=CC=C2.O=S(OC)([O-])=O
MDL No. MFCD00865972
别名 Amezinium metilsulfate; Lu-1631; Risumic; Regulton; methylsulfate; Amezinium
运输蓝冰
InChI Key ZEASXVYVFFXULL-UHFFFAOYSA-N
Pubchem ID 71926
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C

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