Amezinium methylsulfate
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货号：A313059
同义名：
Amezinium metilsulfate; Lu-1631
Amezinium methylsulfate can stimulate α and β-1 receptors and inhibit noradrenaline and tyramine uptake, used as a sympathomimetic drug for the treatment of low blood pressure.
Amezinium methylsulfate 化学结构
Amezinium methylsulfate 3D分子结构
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Amezinium methylsulfate 纯度/质量文件 产品仅供科研
货号：A313059
标准纯度：
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Amezinium methylsulfate 质控信息
Ivabradine HCl
✔
98%
Maprotiline HCl
✔
98%
Cisatracurium besylate
✔
96%
Yohimbine HCI
✔
99+%
BMY 7378
++
α2C-adrenoceptor, pKi: 6.54
α1D-adrenoceptor, pKi: 5.1
+
β1-adrenoceptor, pIC50: 5.1
97%
Asenapine maleate
++++
α2B-adrenergic receptor, pKi: 8.9
α2A-adrenergic receptor, pKi: 8.9
97%
Piribedil
++
adrenoceptor α2A, pKi: 7.1
adrenoceptor α2C, pKi: 7.2
98%
Prazosin HCl
✔
95%
Silodosin
✔
98%
Phenoxybenzamine HCl
✔
98%
Naftopidil
+++
α1D-adrenergic receptor, Ki: 20 nM
α1A-adrenergic receptor, Ki: 3.7 nM
98%
Naftopidil 2HCl
+
α1-adrenergic receptor, IC50: 0.2 μM
99%
Alfuzosin HCl
✔
98%
Terazosin HCl
✔
99%
Atipamezole
✔
95%
Phentolamine methanesulfonate salt
✔
99%
Doxazosin mesylate
✔
99%
Tolazoline HCl
✔
98%
Zenidolol HCl
++++
β1-adrenergic receptor, Ki: 611nM
β2-adrenergic receptor, Ki: 0.7nM
98%
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Amezinium methylsulfate 生物活性
描述
Amezinium metilsulfate is a sympathomimetic drug used for the treatment of low blood pressure. During spinal/epidural anaesthesia 5 mg amezinium is given i.v. if blood pressure dropped greater than 20 mmHg. Amezinium proves a stimulating drug for alpha- and beta 1-receptors by stabilising the systemic blood pressure in spinal/epidural anaesthesia[3] [4] [5]
Amezinium methylsulfate 参考文献
[1] Kitano Y, Nomura S, et al. Leg ulceration during amezinium methylsulfate therapy for hypotension in a hemodialyzed patient with generalized vascular calcification. Nephron. 1995;71(1):115.
[2] Nambu K, Yoshida K, et al. Disposition and metabolism of [14C] -amezinium metilsulfate in rats. Arzneimittelforschung. 1988 Jul;38(7):909-18.
[3] Schaps D, Seitz W, Mehler D, Tholen A, Goroll D. Therapeutische Anwendung von Ameziniummetilsulfat--einem neuen, langwirkenden Sympathikomimetikum--bei rückenmarksnaher Leitungsanästhesie [Therapeutic use of amezinium methylsulfate--a new, long acting, sympathomimetic--in paraspinal conduction anesthesia]. Anasth Intensivther Notfallmed. 1984 Oct;19(5):235-9. German. PMID: 6517242.
[4] Sakakibara R, Uchiyama T, Asahina M, Yoshiyama M, Yamanishi T, Hattori T. Amezinium metilsulfate, a sympathomimetic agent, may increase the risk of urinary retention in multiple system atrophy. Clin Auton Res. 2003 Feb;13(1):51-3.
[5] Kita K, Hirayama K. Treatment of neurogenic orthostatic hypotension with amezinium metilsulfate, a new indirect sympathomimetic drug. Neurology. 1988 Jul;38(7):1095-9.
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Amezinium methylsulfate 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
3.19mL
0.64mL
0.32mL
15.96mL
3.19mL
1.60mL
31.92mL
6.38mL
3.19mL
Amezinium methylsulfate 技术信息
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