Aloe-emodin, a natural product isolated and purified from the root of Rheum palmatum L. with a specific in vitro and in vivo anti-neuroectodermal tumor activity, reduces the toxicity and ROS induced by both monomeric and oligomeric Aβ species, appears to have some protective effect not only against hepatocyte death but also on the inflammatory response subsequent to lipid peroxidation and has a strong non-carcinogenic stimulant-laxative action when applied to the skin, although it may increase the carcinogenicity of some kind of radiation. Aloe-Emodine dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 366μM in the cell-based assay.
Aloe emodin (Rhabarberone) is a natural hydroxyanthraquinone with antitumor properties, capable of binding to and inhibiting the kinase activity of mTORC2, thus exerting antiproliferative effects and inducing apoptosis in cells[1]. It also shows antiviral efficacy against the influenza A virus[2].
Aloe emodin/芦荟大黄素 细胞研究
细胞系
浓度
检测类型
检测时间
活性说明
数据源
A2780 cells
Cytotoxicity assay
Cytotoxicity against human A2780 cells, IC50=26 μM
24326280
HCT116 cells
Cytotoxicity assay
24 h
Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay, IC50=8.7 μM
17949858
HepG2 cells
Cytotoxicity assay
24 h
Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay, IC50=10 μM
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