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Adapalene/阿达帕林 {[allProObj[0].p_purity_real_show]}

货号:A105293 同义名: CD271

Adapalene is an agonist of RAR-β (Kd = 34 nM), RAR-γ (Kd = 130 nM) and RXR which is used in the treatment of acne.

Adapalene/阿达帕林 化学结构 CAS号:106685-40-9
Adapalene/阿达帕林 化学结构
CAS号:106685-40-9
Adapalene/阿达帕林 3D分子结构
CAS号:106685-40-9
Adapalene/阿达帕林 化学结构 CAS号:106685-40-9
Adapalene/阿达帕林 3D分子结构 CAS号:106685-40-9
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Adapalene/阿达帕林 纯度/质量文件 产品仅供科研

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Adapalene/阿达帕林 生物活性

描述 Adapalene (CD271) is a third-generation synthetic retinoid commonly used in acne research. It functions as a potent agonist of retinoic acid receptors (RAR), demonstrating AC50 values of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, and RARα, respectively. Additionally, adapalene inhibits the enzymatic activity of glutamate oxaloacetate transaminase 1 (GOT1) in a non-competitive manner and has shown anti-tumor activity in various studies[1].[2].[3].

Adapalene/阿达帕林 动物研究

Animal study In vivo, adapalene at dosages of 15 to 100 mg/kg administered orally daily for 21 days inhibits the growth of DLD1 cell-derived xenograft tumors in BALB/C nude mice, highlighting its potential for clinical use in cancer therapy[3].

Adapalene/阿达帕林 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02731105 Acne Vulgaris Phase 4 Completed - Germany ... 展开 >> Universitätsklinikum Carl Gustav Carus; Klinik und Poliklinik für Dermatologie Dresden, Saxony, Germany, 01307 收起 <<
NCT02620813 Acne Vulgaris Phase 4 Recruiting May 2019 United States, California ... 展开 >> Dermatology Research Area Recruiting Davis, California, United States, 95616 Contact: Negar Foolad, MAS    916-734-1509    nfoolad@ucdavis.edu    Contact: Lauren A Hassoun, BS    916-734-6550    lahassoun@ucdavis.edu    Principal Investigator: Raja K Sivamani, MD          UC Davis Department of Dermatology Recruiting Sacramento, California, United States, 95816 Contact: Raja Sivamani, MD       rajasivamani@gmail.com 收起 <<
NCT02442817 Schizophrenia Phase 4 Unknown May 2017 United States, Nevada ... 展开 >> University of Nevada School of Medicine Recruiting Reno, Nevada, United States, 89503 Contact: Brian Kirkpatrick, MD    775-682-8449    bkirkpatrick@medicine.nevada.edu    Principal Investigator: Brian Kirkpatrick, MD 收起 <<

Adapalene/阿达帕林 参考文献

[1]Shroot B, et, al. Pharmacology and chemistry of adapalene. J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S96-103.

[2]Wang Q, et, al. Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1. Bioorg Chem. 2019 Dec;93:103315.

[3]Shi XN, et, al. Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma. Mol Med Rep. 2015 Nov;12(5):6501-8.

Adapalene/阿达帕林 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.42mL

0.48mL

0.24mL

12.12mL

2.42mL

1.21mL

24.24mL

4.85mL

2.42mL

Adapalene/阿达帕林 技术信息

CAS号106685-40-9
分子式C28H28O3
分子量 412.52
SMILES Code C4=C(C12CC3CC(C1)CC(C2)C3)C(=CC=C4C6=CC5=CC=C(C=C5C=C6)C(O)=O)OC
MDL No. MFCD03106112
别名 CD271
运输蓝冰
InChI Key LZCDAPDGXCYOEH-UHFFFAOYSA-N
Pubchem ID 60164
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, 2-8°C

动物实验配方

IP 2% DMSO+water 0.2 mg/mL clear

PO 0.5% CMC-Na 42 mg/mL suspension

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