Adapalene is an agonist of RAR-β (Kd = 34 nM), RAR-γ (Kd = 130 nM) and RXR which is used in the treatment of acne.
规格 | 价格 | 会员价 | 库存 | 数量 | |||
---|---|---|---|---|---|---|---|
{[ item.pr_size ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 1周 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
描述 | Adapalene (CD271) is a third-generation synthetic retinoid commonly used in acne research. It functions as a potent agonist of retinoic acid receptors (RAR), demonstrating AC50 values of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, and RARα, respectively. Additionally, adapalene inhibits the enzymatic activity of glutamate oxaloacetate transaminase 1 (GOT1) in a non-competitive manner and has shown anti-tumor activity in various studies[1].[2].[3]. |
Animal study | In vivo, adapalene at dosages of 15 to 100 mg/kg administered orally daily for 21 days inhibits the growth of DLD1 cell-derived xenograft tumors in BALB/C nude mice, highlighting its potential for clinical use in cancer therapy[3]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT02731105 | Acne Vulgaris | Phase 4 | Completed | - | Germany ... 展开 >> Universitätsklinikum Carl Gustav Carus; Klinik und Poliklinik für Dermatologie Dresden, Saxony, Germany, 01307 收起 << |
NCT02620813 | Acne Vulgaris | Phase 4 | Recruiting | May 2019 | United States, California ... 展开 >> Dermatology Research Area Recruiting Davis, California, United States, 95616 Contact: Negar Foolad, MAS 916-734-1509 nfoolad@ucdavis.edu Contact: Lauren A Hassoun, BS 916-734-6550 lahassoun@ucdavis.edu Principal Investigator: Raja K Sivamani, MD UC Davis Department of Dermatology Recruiting Sacramento, California, United States, 95816 Contact: Raja Sivamani, MD rajasivamani@gmail.com 收起 << |
NCT02442817 | Schizophrenia | Phase 4 | Unknown | May 2017 | United States, Nevada ... 展开 >> University of Nevada School of Medicine Recruiting Reno, Nevada, United States, 89503 Contact: Brian Kirkpatrick, MD 775-682-8449 bkirkpatrick@medicine.nevada.edu Principal Investigator: Brian Kirkpatrick, MD 收起 << |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.42mL 0.48mL 0.24mL |
12.12mL 2.42mL 1.21mL |
24.24mL 4.85mL 2.42mL |
CAS号 | 106685-40-9 |
分子式 | C28H28O3 |
分子量 | 412.52 |
SMILES Code | C4=C(C12CC3CC(C1)CC(C2)C3)C(=CC=C4C6=CC5=CC=C(C=C5C=C6)C(O)=O)OC |
MDL No. | MFCD03106112 |
别名 | CD271 |
运输 | 蓝冰 |
InChI Key | LZCDAPDGXCYOEH-UHFFFAOYSA-N |
Pubchem ID | 60164 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Sealed in dry, 2-8°C |
动物实验配方 |
IP 2% DMSO+water 0.2 mg/mL clear PO 0.5% CMC-Na 42 mg/mL suspension |