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/ Aceclofenac/醋氯芬酸

Aceclofenac/醋氯芬酸 {[allProObj[0].p_purity_real_show]}

货号：A683045 同义名： Preservex; Airtal

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of diclofenac.

Aceclofenac/醋氯芬酸 化学结构 CAS号：89796-99-6
Aceclofenac/醋氯芬酸 化学结构
CAS号：89796-99-6
Aceclofenac/醋氯芬酸 3D分子结构
CAS号：89796-99-6
Aceclofenac/醋氯芬酸 化学结构 CAS号：89796-99-6
Aceclofenac/醋氯芬酸 3D分子结构 CAS号：89796-99-6
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Aceclofenac/醋氯芬酸 纯度/质量文件 产品仅供科研

货号：A683045 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

更多 >
产品名称 COX ↓ COX-1 ↓ COX-2 ↓ 其他靶点 纯度
Piroxicam ✔ 98%
Salicylic acid ✔ 98%
Phenacetin ✔ 98%
Etodolac ✔ 99%
Flunixin meglumine ✔ 98%
Ibuprofen L-lysine ✔ 99%
Nabumetone ✔ 98%
Acemetacin ✔ 98%
Diflunisal ✔ 98%
Pranoprofen ✔ 98%
Ampiroxicam ✔ 98%
Meloxicam ✔ 98%
Sulindac ✔ 98%
Ketoprofen ✔ 98%
Mefenamic Acid ✔ 95%
Bromfenac sodium ✔ 98%
Oxaprozin ✔ 99%
Aspirin ✔ 99%
Nepafenac ✔ 98%
Zaltoprofen ✔ 99%
Salicin ✔ 98%
Suprofen ✔ 99%+
Xanthohumol ✔ 99%
Parecoxib ✔ 98%
Tolfenamic Acid +++

COX-2, IC50: 0.2 μM

 		98%
Etoricoxib ✔ 99%
Niflumic Acid ✔ 98%
Valdecoxib ++++

COX-2, IC50: 5 nM

 		99+%
Ibuprofen +

COX-1, IC50: 13 μM

 		+

COX-2, IC50: 370 μM

 		98%
Indomethacin ++

COX1, IC50: 0.28 μM

 		+

COX-2, IC50: 14 μM

 		97%
Lornoxicam ++++

COX-1, IC50: 5 nM

 		++++

COX-2, IC50: 8 nM

 		98%
Meclofenamic acid sodium ++++

COX-1, IC50: 40 nM

 		+++

COX-2, IC50: 50 nM

 		99%
Rofecoxib ++++

COX-2, IC50: 18 nM

 		98%
Asaraldehyde ✔ 98%
Naproxen +

COX-1, IC50: 8.7 μM

 		+

COX-2, IC50: 5.2 μM

 		98%
Diclofenac Sodium Salt +++

COX-1, IC50: 60 nM

 		+++

COX-2, IC50: 200 nM

 		98%
NS-398 ++

COX-2, IC50: 3.8 μM

 		95%
Amfenac Sodium Hydrate ++

COX-1, IC50: 250 nM

 		+++

COX-2, IC50: 150 nM

 		98%+
Nimesulide +

COX-2, IC50: 26 μM

 		98%
Lumiracoxib ++

COX-1, Ki: 3 μM

 		+++

COX-2, Ki: 60 nM

 		99%
Rutaecarpine ✔ 95%
Celecoxib ++++

COX-2, IC50: 40 nM

 		98%
Carprofen ++++

canine COX2, IC50: 30 nM

 		98%
Ketorolac ++

COX-1 (human), IC50: 1.23 μM

 		++

COX-2 (human), IC50: 3.50 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Aceclofenac/醋氯芬酸 生物活性

描述 Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. Aceclofenac works by blocking the action of a substance in the body called cyclo-oxygenase. Aceclofenac inhibited COX-2 more potently than COX-1 (IC50: 3.0/7.3 microM)[3]. Oral administration of aceclofenac induced significant gastric ulceration, which was inhibited by esomeprazole administration. Co-administration of esomeprazole with aceclofenac may reduce aceclofenac-induced gastrointestinal complications without significant pharmacokinetic interactions[4]. In patients with CLBP (chronic lower back pain), aceclofenac CR(controlled release) and aceclofenac demonstrated significant symptomatic pain relief, improvement in quality of life and functional scores[5].

Aceclofenac/醋氯芬酸 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01912066 NSAID-associated Gastroduodena... 展开 >>l Injury 收起 << Phase 4 Completed - Korea, Republic of ... 展开 >> Inje University Busan Paik Hospital Busan, Korea, Republic of, 614735 收起 <<
NCT01952314 Ureter Stones Phase 3 Completed - Korea, Republic of ... 展开 >> Donguk University Ilsan Hospital Goyang, Kyunggi, Korea, Republic of Seoul National University Bundang Hospital Seongnam, Kyunggi, Korea, Republic of, 463-712 Kangwon National University Hospital Chuncheon, Korea, Republic of Seoul National University Hospital Seoul, Korea, Republic of, 110-744 National Medical Center Seoul, Korea, Republic of Seoul National University Boramae Medical Center Seoul, Korea, Republic of 收起 <<
NCT02384928 Sciatica Inte... 展开 >>rvertebral Disc Displacement 收起 << Not Applicable Completed - Korea, Republic of ... 展开 >> Jaseng Hospital of Korean Medicine Seoul, Gangnam-Gu, Korea, Republic of, 135-896 收起 <<

Aceclofenac/醋氯芬酸 参考文献

[1]Narayan R, Pednekar A, et al. A top-down technique to improve the solubility and bioavailability of aceclofenac: in vitro and in vivo studies. Int J Nanomedicine. 2017 Jul 11;12:4921-4935.

[2]Jana S, Sen KK. Chitosan - Locust bean gum interpenetrating polymeric network nanocomposites for delivery of aceclofenac. Int J Biol Macromol. 2017 Sep;102:878-884.

[3]Dannhardt G, Ulbrich H. In-vitro test system for the evaluation of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors based on a single HPLC run with UV detection using bovine aortic coronary endothelial cells (BAECs). Inflamm Res. 2001;50(5):262-269

[4]Kim TH, Thapa SK, Lee DY, et al. Pharmacokinetics and Anti-Gastric Ulceration Activity of Oral Administration of Aceclofenac and Esomeprazole in Rats. Pharmaceutics. 2018;10(3):152. Published 2018 Sep 6

[5]Yang JH, Suk KS, Lee BH, et al. Efficacy and Safety of Different Aceclofenac Treatments for Chronic Lower Back Pain: Prospective, Randomized, Single Center, Open-Label Clinical Trials. Yonsei Med J. 2017;58(3):637-643

Aceclofenac/醋氯芬酸 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.82mL

0.56mL

0.28mL

14.12mL

2.82mL

1.41mL

28.23mL

5.65mL

2.82mL

Aceclofenac/醋氯芬酸 技术信息

CAS号89796-99-6
分子式C16H13Cl2NO4
分子量 354.18
SMILES Code O=C(OCC(O)=O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl
MDL No. MFCD00864296
别名 Preservex; Airtal; Beofenac; YT-919
运输蓝冰
InChI Key MNIPYSSQXLZQLJ-UHFFFAOYSA-N
Pubchem ID 71771
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C
溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二

Tags: Aceclofenac | 89796-99-6 | COX | Cyclooxygenase | Immunology/Inflammation | COX | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Aceclofenac/醋氯芬酸 纯度/质量文件 | Aceclofenac/醋氯芬酸 亚型比较 | Aceclofenac/醋氯芬酸 生物活性 | Aceclofenac/醋氯芬酸 临床数据 | Aceclofenac/醋氯芬酸 参考文献 | Aceclofenac/醋氯芬酸 实验方案 | Aceclofenac/醋氯芬酸 技术信息

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